ENSG00000135506


Homo sapiens

Features
Gene ID: ENSG00000135506
  
Biological name :OS9
  
Synonyms : OS9 / OS9, endoplasmic reticulum lectin / Q13438
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q13.3
Gene start: 57693955
Gene end: 57721557
  
Corresponding Affymetrix probe sets: 200714_x_at (Human Genome U133 Plus 2.0 Array)   215399_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449789
Ensembl peptide - ENSP00000448478
Ensembl peptide - ENSP00000450010
Ensembl peptide - ENSP00000257966
Ensembl peptide - ENSP00000318165
Ensembl peptide - ENSP00000373794
Ensembl peptide - ENSP00000373798
Ensembl peptide - ENSP00000389632
Ensembl peptide - ENSP00000407360
Ensembl peptide - ENSP00000413112
Ensembl peptide - ENSP00000447031
Ensembl peptide - ENSP00000447163
Ensembl peptide - ENSP00000447451
Ensembl peptide - ENSP00000447719
Ensembl peptide - ENSP00000447866
NCBI entrez gene - 10956     See in Manteia.
OMIM - 609677
RefSeq - NM_001261420
RefSeq - NM_001017956
RefSeq - NM_001017957
RefSeq - NM_001017958
RefSeq - NM_001261421
RefSeq - NM_001261422
RefSeq - NM_001261423
RefSeq - NM_006812
RefSeq - XM_005268581
RefSeq - XM_006719200
RefSeq - XM_006719201
RefSeq Peptide - NP_001248352
RefSeq Peptide - NP_006803
RefSeq Peptide - NP_001017956
RefSeq Peptide - NP_001017957
RefSeq Peptide - NP_001017958
RefSeq Peptide - NP_001248349
RefSeq Peptide - NP_001248350
RefSeq Peptide - NP_001248351
swissprot - F8W1N0
swissprot - Q13438
swissprot - F8W1V2
swissprot - B4E321
swissprot - F8VWQ2
swissprot - F8VZI7
swissprot - F8W0R2
Ensembl - ENSG00000135506
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 os9ENSDARG00000020301Danio rerio
 Os9ENSMUSG00000040462Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ERLEC1 / Q96DZ1 / endoplasmic reticulum lectin 1ENSG0000006891218


Protein motifs (from Interpro)
Interpro ID Name
 IPR009011  Mannose-6-phosphate receptor binding domain superfamily
 IPR012913  Protein OS9-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process IMP
 biological_processGO:0006605 protein targeting IEA
 biological_processGO:0006621 protein retention in ER lumen IDA
 biological_processGO:0016567 protein ubiquitination IMP
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IDA
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:1904153 negative regulation of retrograde protein transport, ER to cytosol IMP
 biological_processGO:1904380 endoplasmic reticulum mannose trimming TAS
 cellular_componentGO:0000836 Hrd1p ubiquitin ligase complex NAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005515 protein binding IDA
 molecular_functionGO:0030246 carbohydrate binding IEA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
Hedgehog ligand biogenesis
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
Defective CFTR causes cystic fibrosis
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000071537 SEL1L / Q9UBV2 / SEL1L ERAD E3 ligase adaptor subunit  / reaction / complex
 ENSG00000164690 SHH / Q15465 / sonic hedgehog  / reaction / complex
 ENSG00000162298 SYVN1 / Q86TM6 / synoviolin 1  / complex / reaction
 ENSG00000165280 VCP / P55072 / valosin containing protein  / reaction / complex
 ENSG00000072849 DERL2 / Q9GZP9 / derlin 2  / reaction / complex






 

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