ENSG00000072849


Homo sapiens

Features
Gene ID: ENSG00000072849
  
Biological name :DERL2
  
Synonyms : DERL2 / derlin 2 / Q9GZP9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: p13.2
Gene start: 5471251
Gene end: 5486811
  
Corresponding Affymetrix probe sets: 218333_at (Human Genome U133 Plus 2.0 Array)   226719_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000459083
Ensembl peptide - ENSP00000460671
Ensembl peptide - ENSP00000461603
Ensembl peptide - ENSP00000467794
Ensembl peptide - ENSP00000158771
Ensembl peptide - ENSP00000458296
Ensembl peptide - ENSP00000458448
Ensembl peptide - ENSP00000459072
Ensembl peptide - ENSP00000459154
NCBI entrez gene - 51009     See in Manteia.
OMIM - 610304
RefSeq - NM_016041
RefSeq - NM_001304777
RefSeq - NM_001304779
RefSeq Peptide - NP_057125
RefSeq Peptide - NP_001291708
RefSeq Peptide - NP_001291706
swissprot - Q9GZP9
swissprot - I3L0R8
swissprot - I3L1S8
swissprot - I3L1T3
swissprot - I3L1W3
swissprot - I3L3R8
swissprot - I3L4W7
swissprot - K7EQE8
Ensembl - ENSG00000072849
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 derl2ENSDARG00000042401Danio rerio
 DERL2ENSGALG00000041844Gallus gallus
 Derl2ENSMUSG00000018442Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DERL3 / Q96Q80 / derlin 3ENSG0000009995869
DERL1 / Q9BUN8 / derlin 1ENSG0000013698636


Protein motifs (from Interpro)
Interpro ID Name
 IPR007599  Derlin
 IPR035952  Rhomboid-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001967 suckling behavior IEA
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0030307 positive regulation of cell growth IDA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IMP
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IDA
 biological_processGO:0030970 retrograde protein transport, ER to cytosol IEA
 biological_processGO:1904153 negative regulation of retrograde protein transport, ER to cytosol IMP
 biological_processGO:1904380 endoplasmic reticulum mannose trimming TAS
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005785 signal recognition particle receptor complex IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 cellular_componentGO:0044322 endoplasmic reticulum quality control compartment IEA
 cellular_componentGO:0048500 signal recognition particle IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
Hedgehog ligand biogenesis
Hh mutants that dont undergo autocatalytic processing are degraded by ERAD
Defective CFTR causes cystic fibrosis
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000162298 SYVN1 / Q86TM6 / synoviolin 1  / complex
 ENSG00000071537 SEL1L / Q9UBV2 / SEL1L ERAD E3 ligase adaptor subunit  / complex
 ENSG00000068912 ERLEC1 / Q96DZ1 / endoplasmic reticulum lectin 1  / reaction / complex
 ENSG00000135506 OS9 / Q13438 / OS9, endoplasmic reticulum lectin  / complex / reaction
 ENSG00000164690 SHH / Q15465 / sonic hedgehog  / complex / reaction
 ENSG00000165280 VCP / P55072 / valosin containing protein  / complex






 

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