ENSG00000136986


Homo sapiens

Features
Gene ID: ENSG00000136986
  
Biological name :DERL1
  
Synonyms : DERL1 / derlin 1 / Q9BUN8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: q24.13
Gene start: 123013164
Gene end: 123042423
  
Corresponding Affymetrix probe sets: 218172_s_at (Human Genome U133 Plus 2.0 Array)   219402_s_at (Human Genome U133 Plus 2.0 Array)   222543_at (Human Genome U133 Plus 2.0 Array)   225488_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000384289
Ensembl peptide - ENSP00000430086
Ensembl peptide - ENSP00000429199
Ensembl peptide - ENSP00000389965
Ensembl peptide - ENSP00000259512
NCBI entrez gene - 79139     See in Manteia.
OMIM - 608813
RefSeq - NM_024295
RefSeq - XM_011517299
RefSeq - XM_006716657
RefSeq - NM_001134671
RefSeq Peptide - NP_001128143
RefSeq Peptide - NP_001317530
RefSeq Peptide - NP_077271
swissprot - B4E1G1
swissprot - Q9BUN8
swissprot - E5RGY0
swissprot - A0A024R9G3
Ensembl - ENSG00000136986
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 derl1ENSDARG00000021905Danio rerio
 DERL1ENSGALG00000033950Gallus gallus
 Derl1ENSMUSG00000022365Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DERL2 / Q9GZP9 / derlin 2ENSG0000007284935
DERL3 / Q96Q80 / derlin 3ENSG0000009995831


Protein motifs (from Interpro)
Interpro ID Name
 IPR007599  Derlin
 IPR035952  Rhomboid-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0006986 response to unfolded protein IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016567 protein ubiquitination TAS
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IDA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IDA
 biological_processGO:0030970 retrograde protein transport, ER to cytosol IDA
 biological_processGO:0031398 positive regulation of protein ubiquitination IDA
 biological_processGO:0031648 protein destabilization IMP
 biological_processGO:0032092 positive regulation of protein binding IMP
 biological_processGO:0034620 cellular response to unfolded protein IEA
 biological_processGO:0036503 ERAD pathway IMP
 biological_processGO:0045184 establishment of protein localization TAS
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:0071712 ER-associated misfolded protein catabolic process IMP
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005770 late endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005785 signal recognition particle receptor complex IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 cellular_componentGO:0034098 VCP-NPL4-UFD1 AAA ATPase complex TAS
 cellular_componentGO:0036502 Derlin-1-VIMP complex IDA
 cellular_componentGO:0036513 Derlin-1 retrotranslocation complex IDA
 cellular_componentGO:0048500 signal recognition particle IDA
 molecular_functionGO:0002020 protease binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042288 MHC class I protein binding IDA
 molecular_functionGO:0051117 ATPase binding IPI
 molecular_functionGO:1990381 ubiquitin-specific protease binding IPI


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Defective CFTR causes cystic fibrosis
E3 ubiquitin ligases ubiquitinate target proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136986 DERL1 / Q9BUN8 / derlin 1  / complex






 

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