ENSMUSG00000022365


Mus musculus

Features
Gene ID: ENSMUSG00000022365
  
Biological name :Derl1
  
Synonyms : Derl1 / Derlin-1 / Q99J56
  
Possible biological names infered from orthology : Q9BUN8
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D1
Gene start: 57869502
Gene end: 57892448
  
Corresponding Affymetrix probe sets: 10428736 (MoGene1.0st)   10338496 (MoGene1.0st)   10339097 (MoGene1.0st)   10339402 (MoGene1.0st)   10339652 (MoGene1.0st)   10339984 (MoGene1.0st)   10340131 (MoGene1.0st)   10340656 (MoGene1.0st)   10341141 (MoGene1.0st)   10341574 (MoGene1.0st)   10342949 (MoGene1.0st)   10343030 (MoGene1.0st)   10344325 (MoGene1.0st)   10344425 (MoGene1.0st)   10341490 (MoGene1.0st)   1415693_at (Mouse Genome 430 2.0 Array)   1423082_at (Mouse Genome 430 2.0 Array)   1433563_s_at (Mouse Genome 430 2.0 Array)   1437723_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022993
NCBI entrez gene - 67819     See in Manteia.
MGI - MGI:1915069
RefSeq - NM_024207
RefSeq Peptide - NP_077169
swissprot - Q99J56
Ensembl - ENSMUSG00000022365
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 derl1ENSDARG00000021905Danio rerio
 DERL1ENSGALG00000033950Gallus gallus
 DERL1ENSG00000136986Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Derl2 / Q8BNI4 / Derlin-2 / Q9GZP9*ENSMUSG0000001844233
Derl3 / Q9D8K3 / Mus musculus Der1-like domain family, member 3 (Derl3), transcript variant 2, mRNA. / Q96Q80* / derlin 3*ENSMUSG0000000909229


Protein motifs (from Interpro)
Interpro ID Name
 IPR007599  Derlin
 IPR035952  Rhomboid-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0030970 retrograde protein transport, ER to cytosol IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0031648 protein destabilization IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0034620 cellular response to unfolded protein IMP
 biological_processGO:0036503 ERAD pathway IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0071712 ER-associated misfolded protein catabolic process IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005785 signal recognition particle receptor complex IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane ISO
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 cellular_componentGO:0036502 Derlin-1-VIMP complex IEA
 cellular_componentGO:0036513 Derlin-1 retrotranslocation complex IEA
 cellular_componentGO:0048500 signal recognition particle IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IEA
 molecular_functionGO:0042288 MHC class I protein binding IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:1990381 ubiquitin-specific protease binding IEA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Lrp6skax26/Lrp6+,Vangl2Lp/Vangl2+
Genetic Background: involves: A/J * 129S6/SvEvTac * C57BL/6 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022365 Derl1 / Q99J56 / Derlin-1 / Q9BUN8*  / complex






 

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