ENSMUSG00000018442


Mus musculus

Features
Gene ID: ENSMUSG00000018442
  
Biological name :Derl2
  
Synonyms : Derl2 / Derlin-2 / Q8BNI4
  
Possible biological names infered from orthology : Q9GZP9
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B4
Gene start: 71007164
Gene end: 71019841
  
Corresponding Affymetrix probe sets: 10388033 (MoGene1.0st)   1435101_at (Mouse Genome 430 2.0 Array)   1448438_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127568
Ensembl peptide - ENSMUSP00000104163
Ensembl peptide - ENSMUSP00000117052
Ensembl peptide - ENSMUSP00000136401
Ensembl peptide - ENSMUSP00000135984
Ensembl peptide - ENSMUSP00000136261
NCBI entrez gene - 116891     See in Manteia.
MGI - MGI:2151483
RefSeq - NM_001291147
RefSeq - NM_001291148
RefSeq - NM_033562
RefSeq - NM_001291146
RefSeq Peptide - NP_001278075
RefSeq Peptide - NP_001278077
RefSeq Peptide - NP_291040
RefSeq Peptide - NP_001278076
swissprot - Q8BNI4
swissprot - J3QMQ7
swissprot - J3KMR6
swissprot - Q3U957
swissprot - J3QMF4
Ensembl - ENSMUSG00000018442
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 derl2ENSDARG00000042401Danio rerio
 DERL2ENSGALG00000041844Gallus gallus
 DERL2ENSG00000072849Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Derl3 / Q9D8K3 / Mus musculus Der1-like domain family, member 3 (Derl3), transcript variant 2, mRNA. / Q96Q80* / derlin 3*ENSMUSG0000000909270
Derl1 / Q99J56 / Derlin-1 / Q9BUN8*ENSMUSG0000002236535


Protein motifs (from Interpro)
Interpro ID Name
 IPR007599  Derlin
 IPR035952  Rhomboid-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001967 suckling behavior IMP
 biological_processGO:0006986 response to unfolded protein IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IEA
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IEA
 biological_processGO:0030970 retrograde protein transport, ER to cytosol IEA
 biological_processGO:1904153 negative regulation of retrograde protein transport, ER to cytosol IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005785 signal recognition particle receptor complex IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IEA
 cellular_componentGO:0048500 signal recognition particle IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
Hedgehog ligand biogenesis
ER Quality Control Compartment (ERQC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
Show

Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0001942 abnormal lung volume "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0010082 sternebra fusion "appearance of one or more sternebrae as a single structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0010099 abnormal thoracic cage shape "anomaly in the overall regular dome shape of the ribcage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Calb2tm2.1(cre/ERT2)Zjh/Calb2+
Genetic Background: involves: C57BL/6 * SJL

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002633 Shh / Q62226 / Sonic hedgehog protein Sonic hedgehog protein N-product / Q15465* / sonic hedgehog*  / reaction / complex
 ENSMUSG00000040462 Os9 / Q8K2C7 / Protein OS-9 / Q13438* / OS9, endoplasmic reticulum lectin*  / complex / reaction
 ENSMUSG00000020311 Erlec1 / Q8VEH8 / Endoplasmic reticulum lectin 1 / Q96DZ1*  / complex / reaction
 ENSMUSG00000020964 Sel1l / Q9Z2G6 / sel-1 suppressor of lin-12-like (C. elegans) / Q9UBV2* / SEL1L ERAD E3 ligase adaptor subunit*  / complex
 ENSMUSG00000024807 Syvn1 / synovial apoptosis inhibitor 1, synoviolin / Q86TM6* / synoviolin 1*  / complex
 ENSMUSG00000028452 Vcp / Q01853 / valosin containing protein / P55072*  / complex






 

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