ENSG00000099958


Homo sapiens

Features
Gene ID: ENSG00000099958
  
Biological name :DERL3
  
Synonyms : DERL3 / derlin 3 / Q96Q80
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q11.23
Gene start: 23834503
Gene end: 23839128
  
Corresponding Affymetrix probe sets: 228897_at (Human Genome U133 Plus 2.0 Array)   229721_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000419399
Ensembl peptide - ENSP00000315303
Ensembl peptide - ENSP00000384473
Ensembl peptide - ENSP00000384744
NCBI entrez gene - 91319     See in Manteia.
OMIM - 610305
RefSeq - XM_017029082
RefSeq - NM_001002862
RefSeq - NM_001135751
RefSeq - NM_198440
RefSeq - XM_011530506
RefSeq - XM_017029078
RefSeq - XM_017029079
RefSeq - XM_017029080
RefSeq - XM_017029081
RefSeq - XM_011530505
RefSeq Peptide - NP_001002862
RefSeq Peptide - NP_001129223
RefSeq Peptide - NP_940842
swissprot - Q96Q80
swissprot - E7EVA4
Ensembl - ENSG00000099958
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 derl3ENSDARG00000033871Danio rerio
 DERL3ENSGALG00000005994Gallus gallus
 Derl3ENSMUSG00000009092Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DERL2 / Q9GZP9 / derlin 2ENSG0000007284969
DERL1 / Q9BUN8 / derlin 1ENSG0000013698633


Protein motifs (from Interpro)
Interpro ID Name
 IPR007599  Derlin
 IPR035952  Rhomboid-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0018279 protein N-linked glycosylation via asparagine IMP
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway NAS
 biological_processGO:0030968 endoplasmic reticulum unfolded protein response IDA
 biological_processGO:1904153 negative regulation of retrograde protein transport, ER to cytosol IMP
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005785 signal recognition particle receptor complex IDA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane IDA
 cellular_componentGO:0048500 signal recognition particle IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
Defective CFTR causes cystic fibrosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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