ENSMUSG00000007279


Mus musculus

Features
Gene ID: ENSMUSG00000007279
  
Biological name :Scube2
  
Synonyms : Q9JJS0 / Scube2 / Signal peptide, CUB and EGF-like domain-containing protein 2
  
Possible biological names infered from orthology : Q9NQ36 / signal peptide, CUB domain and EGF like domain containing 2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E3
Gene start: 109798676
Gene end: 109865679
  
Corresponding Affymetrix probe sets: 10566822 (MoGene1.0st)   1453486_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000007423
Ensembl peptide - ENSMUSP00000102340
Ensembl peptide - ENSMUSP00000102339
NCBI entrez gene - 56788     See in Manteia.
MGI - MGI:1928765
RefSeq - NM_020052
RefSeq Peptide - NP_064436
swissprot - D3YVN5
swissprot - D3YVM9
swissprot - Q9JJS0
Ensembl - ENSMUSG00000007279
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scube2ENSDARG00000037362Danio rerio
 SCUBE2ENSGALG00000032161Gallus gallus
 Q9NQ36ENSG00000175356Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6NZL8 / Scube1 / signal peptide, CUB domain, EGF-like 1 / Q8IWY4* / signal peptide, CUB domain and EGF like domain containing 1*ENSMUSG0000001676365
Q66PY1 / Scube3 / Signal peptide, CUB and EGF-like domain-containing protein 3 / Q8IX30* / signal peptide, CUB domain and EGF like domain containing 3*ENSMUSG0000003867758
Matn2 / O08746 / Mus musculus matrilin 2 (Matn2), transcript variant 1, mRNA. / O00339* / matrilin 2*ENSMUSG0000002232413
Cd93 / O89103 / Complement component C1q receptor / Q9NPY3* / CD93 molecule*ENSMUSG0000002743512
Thbd / P15306 / thrombomodulin / P07204*ENSMUSG0000007474311
Cd248 / Q91V98 / Endosialin / Q9HCU0* / CD248 molecule*ENSMUSG0000005648110
Matn4 / matrilin 4 / O95460*ENSMUSG000000169959
Matn3 / O35701 / Matrilin-3 / O15232*ENSMUSG000000205837
Q8VCP9 / Clec14a / C-type lectin domain family 14 member A / Q86T13* / C-type lectin domain containing 14A*ENSMUSG000000459307
Matn1 / P51942 / Cartilage matrix protein / P21941* / matrilin 1, cartilage matrix protein*ENSMUSG000000405337
Vwa1 / Q8R2Z5 / von Willebrand factor A domain containing 1 / Q6PCB0*ENSMUSG000000421163


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024731  EGF domain
 IPR026823  Complement Clr-like EGF domain
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IMP
 biological_processGO:0045778 positive regulation of ossification IMP
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IDA
 biological_processGO:1902732 positive regulation of chondrocyte proliferation IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0009986 cell surface IBA
 cellular_componentGO:0019897 extrinsic component of plasma membrane ISO
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0097108 hedgehog family protein binding IPI


Pathways (from Reactome)
Pathway description
Release of Hh-Np from the secreting cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0000135 reduced cortical bone thickness "thinner than normal superficial layer of compact bone " [J:61509]
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Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

Allelic Composition: Scube2tm1Rbya/Scube2tm1Rbya
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
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Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0008272 abnormal endochondral bone ossification "anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone" [GO:0001958]
Show

Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0013616 decreased volumetric bone mineral density "reduction in the mineral mass per unit volume of bone, the hard, rigid form of connective tissue constituting most of the skeleton of vertebrates and composed chiefly of calcium salts; this is expressed as the amount of mineral per cubic cm of bone (usually in mgHA/cm^3), with results generated from Quantitative computed tomography (QCT) and other tests" [PMID:12730800, PMID:17481978]
Show

Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0014101 decreased chondrocyte proliferation "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
Show

Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

 MP:0014105 abnormal chondrocyte differentiation "any anomaly in the process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte" [GO:0002062]
Show

Allelic Composition: Ttntm2.1Hgra/Ttntm2.1Hgra
Genetic Background: B6J.Cg-Ttntm2.1Hgra

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002633 Shh / Q62226 / Sonic hedgehog protein Sonic hedgehog protein N-product / Q15465* / sonic hedgehog*  / complex / reaction
 ENSMUSG00000040035 2 / Disp2 / Q8CIP5 / A7MBM2* / dispatched RND transporter family member 2*  / reaction






 

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