ENSMUSG00000042116


Mus musculus

Features
Gene ID: ENSMUSG00000042116
  
Biological name :Vwa1
  
Synonyms : Q8R2Z5 / von Willebrand factor A domain containing 1 / Vwa1
  
Possible biological names infered from orthology : Q6PCB0
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 155768149
Gene end: 155774698
  
Corresponding Affymetrix probe sets: 10519196 (MoGene1.0st)   1426399_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000040405
NCBI entrez gene - 246228     See in Manteia.
MGI - MGI:2179729
RefSeq - NM_147776
RefSeq Peptide - NP_680085
swissprot - Q8R2Z5
Ensembl - ENSMUSG00000042116
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 vwa1ENSDARG00000075468Danio rerio
 VWA1ENSGALG00000001527Gallus gallus
 VWA1ENSG00000179403Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Matn4 / matrilin 4 / O95460*ENSMUSG0000001699523
Matn2 / O08746 / Mus musculus matrilin 2 (Matn2), transcript variant 1, mRNA. / O00339* / matrilin 2*ENSMUSG0000002232422
Matn3 / O35701 / Matrilin-3 / O15232*ENSMUSG0000002058320
Matn1 / P51942 / Cartilage matrix protein / P21941* / matrilin 1, cartilage matrix protein*ENSMUSG0000004053319
Q6NZL8 / Scube1 / signal peptide, CUB domain, EGF-like 1 / Q8IWY4* / signal peptide, CUB domain and EGF like domain containing 1*ENSMUSG000000167638
Cd93 / O89103 / Complement component C1q receptor / Q9NPY3* / CD93 molecule*ENSMUSG000000274358
Q66PY1 / Scube3 / Signal peptide, CUB and EGF-like domain-containing protein 3 / Q8IX30* / signal peptide, CUB domain and EGF like domain containing 3*ENSMUSG000000386778
Q9JJS0 / Scube2 / Signal peptide, CUB and EGF-like domain-containing protein 2 / Q9NQ36* / signal peptide, CUB domain and EGF like domain containing 2*ENSMUSG000000072798
Thbd / P15306 / thrombomodulin / P07204*ENSMUSG000000747437
Cd248 / Q91V98 / Endosialin / Q9HCU0* / CD248 molecule*ENSMUSG000000564817
Q8VCP9 / Clec14a / C-type lectin domain family 14 member A / Q86T13* / C-type lectin domain containing 14A*ENSMUSG000000459304


Protein motifs (from Interpro)
Interpro ID Name
 IPR002035  von Willebrand factor, type A
 IPR003961  Fibronectin type III
 IPR013783  Immunoglobulin-like fold
 IPR036116  Fibronectin type III superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0048266 behavioral response to pain IMP
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005614 interstitial matrix IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IDA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003632 abnormal nervous system morphology 
Show

Allelic Composition: Ptpn11tm3Bgn/Ptpn11tm3Bgn
Genetic Background: involves: 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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