ENSMUSG00000016763


Mus musculus

Features
Gene ID: ENSMUSG00000016763
  
Biological name :Scube1
  
Synonyms : Q6NZL8 / Scube1 / signal peptide, CUB domain, EGF-like 1
  
Possible biological names infered from orthology : Q8IWY4 / signal peptide, CUB domain and EGF like domain containing 1
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 83604999
Gene end: 83725021
  
Corresponding Affymetrix probe sets: 10431051 (MoGene1.0st)   1449850_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000016907
Ensembl peptide - ENSMUSP00000044835
Ensembl peptide - ENSMUSP00000075434
Ensembl peptide - ENSMUSP00000130131
NCBI entrez gene - 64706     See in Manteia.
MGI - MGI:1890616
RefSeq - XM_017316719
RefSeq - NM_001271472
RefSeq - NM_001271473
RefSeq - NM_022723
RefSeq - XM_006521242
RefSeq - XM_006521243
RefSeq - XM_011245707
RefSeq Peptide - NP_001258401
RefSeq Peptide - NP_001258402
RefSeq Peptide - NP_073560
swissprot - Q68EF9
swissprot - Q6NZL8
swissprot - A2A442
Ensembl - ENSMUSG00000016763
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scube1ENSDARG00000063097Danio rerio
 SCUBE1ENSGALG00000014178Gallus gallus
 Q8IWY4ENSG00000159307Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q66PY1 / Scube3 / Signal peptide, CUB and EGF-like domain-containing protein 3 / Q8IX30* / signal peptide, CUB domain and EGF like domain containing 3*ENSMUSG0000003867764
Q9JJS0 / Scube2 / Signal peptide, CUB and EGF-like domain-containing protein 2 / Q9NQ36* / signal peptide, CUB domain and EGF like domain containing 2*ENSMUSG0000000727961
Matn2 / O08746 / Mus musculus matrilin 2 (Matn2), transcript variant 1, mRNA. / O00339* / matrilin 2*ENSMUSG0000002232414
Cd93 / O89103 / Complement component C1q receptor / Q9NPY3* / CD93 molecule*ENSMUSG0000002743513
Thbd / P15306 / thrombomodulin / P07204*ENSMUSG0000007474312
Cd248 / Q91V98 / Endosialin / Q9HCU0* / CD248 molecule*ENSMUSG0000005648111
Matn4 / matrilin 4 / O95460*ENSMUSG0000001699510
Matn3 / O35701 / Matrilin-3 / O15232*ENSMUSG000000205838
Q8VCP9 / Clec14a / C-type lectin domain family 14 member A / Q86T13* / C-type lectin domain containing 14A*ENSMUSG000000459307
Matn1 / P51942 / Cartilage matrix protein / P21941* / matrilin 1, cartilage matrix protein*ENSMUSG000000405336
Vwa1 / Q8R2Z5 / von Willebrand factor A domain containing 1 / Q6PCB0*ENSMUSG000000421163


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024731  EGF domain
 IPR026823  Complement Clr-like EGF domain
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IDA
 biological_processGO:0051260 protein homooligomerization ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane ISS
 cellular_componentGO:0009986 cell surface IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISS


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000075 absent neurocranium "missing bones of the skull enclosing the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0000783 abnormal forebrain morphology "malformed or absent anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0000830 abnormal diencephalon morphology "any malformation or absence of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0000846 abnormal medulla oblongata "anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0001081 abnormal cranial ganglia morphology "any anomaly, deformity, or malformation of the groups of nerve cell bodies associated with the twelve cranial nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ikbkaptm1Id/Ikbkaptm1.1Id,Tg(IKBKAP*)#Sasl/0
Genetic Background: involves: 129S1/Sv * C57BL/6N

 MP:0002856 abnormal vestibular ganglion morphology "malformation of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0003104 acrania "complete or partial absence of a skull; usually associated with anencephaly" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:33716]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0004377 small frontal bone "reduced size of the bone forming the forehead and roof of the eye orbit" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0004383 absent interparietal bone "absence of the bone of the cranium that lies above and anterior to the occipital bone in some mammals" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0004418 small parietal bone "reduced size of the curved bone forming part of the vault of the cranium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0004443 absent supraoccipital bone "absence of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0004459 small alisphenoid bone "reduced size of either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Ikbkaptm1Id/Ikbkaptm1.1Id,Tg(IKBKAP*)#Sasl/0
Genetic Background: involves: 129S1/Sv * C57BL/6N

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
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Allelic Composition: Ikbkaptm1Id/Ikbkaptm1.1Id,Tg(IKBKAP*)#Sasl/0
Genetic Background: involves: 129S1/Sv * C57BL/6N

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ikbkaptm1Id/Ikbkaptm1.1Id,Tg(IKBKAP*)#Sasl/0
Genetic Background: involves: 129S1/Sv * C57BL/6N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0012686 everted embryonic neuroepithelium "an inside-out appearance of the embryonic neuroepithelium characteristic of defective primary neurulation resulting from failure of neural fold elevation; everted neural folds assume a convex instead of a concave morphology and fail to bend toward each other and fuse at the dorsal midline leading to exencephaly" [MGI:anna]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0012702 increased embryonic neuroepithelium thickness "increased width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0012705 increased embryonic neuroepithelial cell proliferation "increase in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, MGI:anna]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

 MP:0030121 small temporal bone squamous part "reduced size of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault" [MGI:anna]
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Allelic Composition: Nr2e1tm1Gsc/Nr2e1tm1Gsc
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000016763 Q6NZL8 / Scube1 / signal peptide, CUB domain, EGF-like 1 / Q8IWY4* / signal peptide, CUB domain and EGF like domain containing 1*  / -
 ENSMUSG00000038677 Q66PY1 / Scube3 / Signal peptide, CUB and EGF-like domain-containing protein 3 / Q8IX30* / signal peptide, CUB domain and EGF like domain containing 3*  / -






 

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