ENSG00000159307


Homo sapiens

Features
Gene ID: ENSG00000159307
  
Biological name :SCUBE1
  
Synonyms : Q8IWY4 / SCUBE1 / signal peptide, CUB domain and EGF like domain containing 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q13.2
Gene start: 43197283
Gene end: 43343388
  
Corresponding Affymetrix probe sets: 1552388_at (Human Genome U133 Plus 2.0 Array)   233988_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000354080
Ensembl peptide - ENSP00000484780
Ensembl peptide - ENSP00000395327
Ensembl peptide - ENSP00000290460
NCBI entrez gene - 80274     See in Manteia.
OMIM - 611746
RefSeq - XM_005261752
RefSeq - XM_011530390
RefSeq - XM_011530389
RefSeq - NM_173050
RefSeq Peptide - NP_766638
swissprot - Q8IWY4
swissprot - B1AH90
swissprot - H0Y4Y9
swissprot - A0A087X285
Ensembl - ENSG00000159307
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scube1ENSDARG00000063097Danio rerio
 SCUBE1ENSGALG00000014178Gallus gallus
 Q6NZL8ENSMUSG00000016763Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8IX30 / SCUBE3 / signal peptide, CUB domain and EGF like domain containing 3ENSG0000014619766
Q9NQ36 / SCUBE2 / signal peptide, CUB domain and EGF like domain containing 2ENSG0000017535665
CD93 / Q9NPY3 / CD93 moleculeENSG0000012581014
MATN2 / O00339 / matrilin 2ENSG0000013256114
CD248 / Q9HCU0 / CD248 moleculeENSG0000017480712
THBD / P07204 / thrombomodulinENSG0000017872612
MATN4 / O95460 / matrilin 4ENSG000001241599
Q86T13 / CLEC14A / C-type lectin domain containing 14AENSG000001764357
MATN1 / P21941 / matrilin 1, cartilage matrix proteinENSG000001625106
MATN3 / O15232 / matrilin 3ENSG000001320316
VWA1 / Q6PCB0 / von Willebrand factor A domain containing 1ENSG000001794034


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024731  EGF domain
 IPR026823  Complement Clr-like EGF domain
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response NAS
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007512 adult heart development NAS
 biological_processGO:0007596 blood coagulation NAS
 biological_processGO:0009791 post-embryonic development NAS
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045446 endothelial cell differentiation NAS
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0051260 protein homooligomerization IPI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0019897 extrinsic component of plasma membrane IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IDA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000146197 Q8IX30 / SCUBE3 / signal peptide, CUB domain and EGF like domain containing 3  / -
 ENSG00000159307 Q8IWY4 / SCUBE1 / signal peptide, CUB domain and EGF like domain containing 1  / -






 

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