ENSDARG00000063097


Danio rerio

Features
Gene ID: ENSDARG00000063097
  
Biological name :scube1
  
Synonyms : scube1 / signal peptide, CUB domain, EGF-like 1
  
Possible biological names infered from orthology : Q6NZL8 / Q8IWY4 / signal peptide, CUB domain and EGF like domain containing 1
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 8906893
Gene end: 9008851
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000130316
Ensembl peptide - ENSDARP00000135955
NCBI entrez gene - 797832     See in Manteia.
RefSeq - NM_001260500
RefSeq - NM_001328599
RefSeq Peptide - NP_001247429
RefSeq Peptide - NP_001315528
swissprot - A0A0R4IBT9
swissprot - A0A0R4IN49
ZFIN ID - ZDB-GENE-050302-78
Ensembl - ENSDARG00000063097
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SCUBE1ENSGALG00000014178Gallus gallus
 Q8IWY4ENSG00000159307Homo sapiens
 Q6NZL8ENSMUSG00000016763Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
scube2 / signal peptide, CUB domain, EGF-like 2 / Q9NQ36* / Q9JJS0* / signal peptide, CUB domain and EGF like domain containing 2* / Signal peptide, CUB and EGF-like domain-containing protein 2 *ENSDARG0000003736262
scube3 / signal peptide, CUB domain, EGF-like 3 / Q8IX30* / signal peptide, CUB domain and EGF like domain containing 3*ENSDARG0000001149061
matn4 / matrilin 4 / Q8VCP9* / O95460* / Q86T13* / CLEC14A* / C-type lectin domain containing 14A* / C-type lectin domain family 14 member A *ENSDARG0000001594712
cd248a / CD248 molecule, endosialin a / CD248* / Q9HCU0* / Q91V98* / Endosialin * / CD248 molecule*ENSDARG0000010371312
cd248b / CD248 molecule, endosialin b / CD248* / Q9HCU0* / Q91V98* / Endosialin * / CD248 molecule*ENSDARG0000007793812
si:dkey-163f14.6ENSDARG0000009160211
thbd / thrombomodulin / P07204* / P15306*ENSDARG0000009247010
matn1 / matrilin 1 / P21941* / P51942* / Cartilage matrix protein * / matrilin 1, cartilage matrix protein*ENSDARG000000302155
matn3a / matrilin 3a / MATN3* / O35701* / O15232* / matrilin 3*ENSDARG000000692453
matn3b / matrilin 3b / MATN3* / O35701* / O15232* / matrilin 3*ENSDARG000000692653
vwa1 / von Willebrand factor A domain containing 1 / Q6PCB0* / Q8R2Z5*ENSDARG000000754683


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024731  EGF domain
 IPR026823  Complement Clr-like EGF domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007224 smoothened signaling pathway IGI
 biological_processGO:0030509 BMP signaling pathway IDA
 biological_processGO:0048747 muscle fiber development IGI
 biological_processGO:0060215 primitive hemopoiesis IMP
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000155 somite somite morphology , abnormal
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 ZFA:0001094 whole organism whole organism anterior-posterior axis shortened , abnormal
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 ZFA:0005040 posterior lateral mesoderm posterior lateral mesoderm decreased distribution , abnormal
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 ZFA:0005042 posterior lateral plate mesoderm posterior lateral plate mesoderm morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000011490 scube3 / signal peptide, CUB domain, EGF-like 3 / Q8IX30* / signal peptide, CUB domain and EGF like domain containing 3*  / -
 ENSDARG00000063097 scube1 / signal peptide, CUB domain, EGF-like 1 / Q6NZL8* / Q8IWY4* / signal peptide, CUB domain and EGF like domain containing 1*  / -






 

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