ENSG00000175356


Homo sapiens

Features
Gene ID: ENSG00000175356
  
Biological name :SCUBE2
  
Synonyms : Q9NQ36 / SCUBE2 / signal peptide, CUB domain and EGF like domain containing 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.4
Gene start: 9020391
Gene end: 9138114
  
Corresponding Affymetrix probe sets: 219197_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000435415
Ensembl peptide - ENSP00000434000
Ensembl peptide - ENSP00000435902
Ensembl peptide - ENSP00000310658
Ensembl peptide - ENSP00000415187
Ensembl peptide - ENSP00000429969
Ensembl peptide - ENSP00000432828
NCBI entrez gene - 57758     See in Manteia.
OMIM - 611747
RefSeq - XM_017018082
RefSeq - XM_005253034
RefSeq - XM_005253035
RefSeq - XM_005253036
RefSeq - XM_005253037
RefSeq - XM_011520246
RefSeq - XM_011520247
RefSeq - XM_011520248
RefSeq - XM_017018080
RefSeq - XM_017018081
RefSeq - NM_001170690
RefSeq - NM_020974
RefSeq - XM_005253032
RefSeq - XM_005253033
RefSeq Peptide - NP_001164161
RefSeq Peptide - NP_001317128
RefSeq Peptide - NP_066025
swissprot - H0YEI5
swissprot - H0YD28
swissprot - A0A0A0MTC8
swissprot - Q9NQ36
swissprot - H0YDN3
swissprot - H0YEB3
Ensembl - ENSG00000175356
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scube2ENSDARG00000037362Danio rerio
 SCUBE2ENSGALG00000032161Gallus gallus
 Q9JJS0ENSMUSG00000007279Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8IWY4 / SCUBE1 / signal peptide, CUB domain and EGF like domain containing 1ENSG0000015930764
Q8IX30 / SCUBE3 / signal peptide, CUB domain and EGF like domain containing 3ENSG0000014619760
MATN2 / O00339 / matrilin 2ENSG0000013256113
CD93 / Q9NPY3 / CD93 moleculeENSG0000012581012
THBD / P07204 / thrombomodulinENSG0000017872611
CD248 / Q9HCU0 / CD248 moleculeENSG0000017480711
MATN4 / O95460 / matrilin 4ENSG000001241599
MATN3 / O15232 / matrilin 3ENSG000001320317
Q86T13 / CLEC14A / C-type lectin domain containing 14AENSG000001764357
MATN1 / P21941 / matrilin 1, cartilage matrix proteinENSG000001625106
VWA1 / Q6PCB0 / von Willebrand factor A domain containing 1ENSG000001794034


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024731  EGF domain
 IPR026823  Complement Clr-like EGF domain
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0030154 cell differentiation IBA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008289 lipid binding IEA


Pathways (from Reactome)
Pathway description
Release of Hh-Np from the secreting cell


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164690 SHH / Q15465 / sonic hedgehog  / reaction / complex
 ENSG00000140323 DISP2 / A7MBM2 / dispatched RND transporter family member 2  / reaction






 

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