ENSG00000146197


Homo sapiens

Features
Gene ID: ENSG00000146197
  
Biological name :SCUBE3
  
Synonyms : Q8IX30 / SCUBE3 / signal peptide, CUB domain and EGF like domain containing 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: p21.31
Gene start: 35214419
Gene end: 35253079
  
Corresponding Affymetrix probe sets: 217600_at (Human Genome U133 Plus 2.0 Array)   228407_at (Human Genome U133 Plus 2.0 Array)   230253_at (Human Genome U133 Plus 2.0 Array)   230290_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000274938
NCBI entrez gene - 222663     See in Manteia.
OMIM - 614708
RefSeq - XM_011514404
RefSeq - NM_001303136
RefSeq - NM_152753
RefSeq - XM_005248943
RefSeq - XM_005248947
RefSeq Peptide - NP_001290065
RefSeq Peptide - NP_689966
swissprot - Q8IX30
Ensembl - ENSG00000146197
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scube3ENSDARG00000011490Danio rerio
 SCUBE3ENSGALG00000002675Gallus gallus
 Q66PY1ENSMUSG00000038677Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8IWY4 / SCUBE1 / signal peptide, CUB domain and EGF like domain containing 1ENSG0000015930766
Q9NQ36 / SCUBE2 / signal peptide, CUB domain and EGF like domain containing 2ENSG0000017535660
MATN2 / O00339 / matrilin 2ENSG0000013256113
CD93 / Q9NPY3 / CD93 moleculeENSG0000012581013
THBD / P07204 / thrombomodulinENSG0000017872612
CD248 / Q9HCU0 / CD248 moleculeENSG0000017480711
MATN4 / O95460 / matrilin 4ENSG000001241599
Q86T13 / CLEC14A / C-type lectin domain containing 14AENSG000001764357
MATN3 / O15232 / matrilin 3ENSG000001320317
MATN1 / P21941 / matrilin 1, cartilage matrix proteinENSG000001625106
VWA1 / Q6PCB0 / von Willebrand factor A domain containing 1ENSG000001794034


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024731  EGF domain
 IPR026823  Complement Clr-like EGF domain
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IEA
 biological_processGO:0051260 protein homooligomerization IDA
 biological_processGO:0051291 protein heterooligomerization IPI
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000087245 MMP2 / P08253 / matrix metallopeptidase 2  / reaction
 ENSG00000146197 Q8IX30 / SCUBE3 / signal peptide, CUB domain and EGF like domain containing 3  / -
 ENSG00000159307 Q8IWY4 / SCUBE1 / signal peptide, CUB domain and EGF like domain containing 1  / -
 ENSG00000100985 MMP9 / P14780 / matrix metallopeptidase 9  / reaction






 

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