ENSMUSG00000038677


Mus musculus

Features
Gene ID: ENSMUSG00000038677
  
Biological name :Scube3
  
Synonyms : Q66PY1 / Scube3 / Signal peptide, CUB and EGF-like domain-containing protein 3
  
Possible biological names infered from orthology : Q8IX30 / signal peptide, CUB domain and EGF like domain containing 3
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: A3.3
Gene start: 28142316
Gene end: 28174852
  
Corresponding Affymetrix probe sets: 10443276 (MoGene1.0st)   1436002_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038366
Ensembl peptide - ENSMUSP00000117490
NCBI entrez gene - 268935     See in Manteia.
MGI - MGI:3045253
RefSeq - XM_011246477
RefSeq - NM_001004366
RefSeq - XM_006524323
RefSeq - XM_006524324
RefSeq Peptide - NP_001004366
swissprot - F7A487
swissprot - Q66PY1
Ensembl - ENSMUSG00000038677
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 scube3ENSDARG00000011490Danio rerio
 SCUBE3ENSGALG00000002675Gallus gallus
 Q8IX30ENSG00000146197Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q6NZL8 / Scube1 / signal peptide, CUB domain, EGF-like 1 / Q8IWY4* / signal peptide, CUB domain and EGF like domain containing 1*ENSMUSG0000001676366
Q9JJS0 / Scube2 / Signal peptide, CUB and EGF-like domain-containing protein 2 / Q9NQ36* / signal peptide, CUB domain and EGF like domain containing 2*ENSMUSG0000000727956
Matn2 / O08746 / Mus musculus matrilin 2 (Matn2), transcript variant 1, mRNA. / O00339* / matrilin 2*ENSMUSG0000002232414
Cd93 / O89103 / Complement component C1q receptor / Q9NPY3* / CD93 molecule*ENSMUSG0000002743513
Thbd / P15306 / thrombomodulin / P07204*ENSMUSG0000007474312
Cd248 / Q91V98 / Endosialin / Q9HCU0* / CD248 molecule*ENSMUSG0000005648111
Matn4 / matrilin 4 / O95460*ENSMUSG0000001699510
Matn3 / O35701 / Matrilin-3 / O15232*ENSMUSG000000205838
Q8VCP9 / Clec14a / C-type lectin domain family 14 member A / Q86T13* / C-type lectin domain containing 14A*ENSMUSG000000459307
Matn1 / P51942 / Cartilage matrix protein / P21941* / matrilin 1, cartilage matrix protein*ENSMUSG000000405336
Vwa1 / Q8R2Z5 / von Willebrand factor A domain containing 1 / Q6PCB0*ENSMUSG000000421163


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000742  EGF-like domain
 IPR000859  CUB domain
 IPR001881  EGF-like calcium-binding domain
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024731  EGF domain
 IPR026823  Complement Clr-like EGF domain
 IPR035914  Spermadhesin, CUB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030154 cell differentiation IBA
 biological_processGO:0045880 positive regulation of smoothened signaling pathway IDA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0051291 protein heterooligomerization IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IBA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000026 abnormal inner ear morphology "malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0000029 abnormal malleus morphology "structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0000194 hypercalcemia "abnormally high concentration of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0000198 hypophosphatemia "abnormally low concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0001362 abnormal anxiety-related response "altered emotional response related to anticipation of a non-specific threat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, CFG:Center for Functional Genomics, Northwestern University]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0002110 abnormal digit morphology "abnormal development of the digits resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Slc6a3tm1Wzh/Slc6a3tm1Wzh
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Scube3tm1(KOMP)Vlcg/Scube3tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6NTac

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0002757 reduced vertical activity "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0002963 decreased protein excretion "less than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0003049 abnormal lumbar vertebrae morphology "malformation of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0003072 abnormal metatarsal bone morphology "anomaly in the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0003073 abnormal metacarpal bone morphology "anomaly in the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0003870 decreased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0004508 abnormal shoulder bone morphology "any structural anomaly of the bones of the shoulder by which the limbs attach to the axial skeleton " [MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0004604 abnormal vertebral pedicle morphology "any structural anomaly of the two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0004739 conductive hearing loss "progressive hearing loss due to lesions in the external auditory canal or middle ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005104 abnormal tarsus morphology "malformation or absence of any of the eight bones of the instep of the paw: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005105 abnormal middle ear ossicle morphology "anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005272 abnormal temporal bone morphology "anomalous structure of the large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005451 abnormal body composition "anomalous relative amounts of various components of the body, such as percent body fat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005540 decreased albumin excretion "less than the normal amount of this protein voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005574 decreased breathing frequency "fewer than the normal number of breaths in a given period of time" [RGD:Rat Genome Database submission]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0005627 increased circulating potassium level "greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0008730 fused phalanges "anomaly of the long bones of the digits resulting in some or all the bones being joined together" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0008821 increased blood uric acid level "greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0010325 abnormal malleus head morphology "any structural anomaly of the rounded portion of the malleus articulating with the body of the incus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0011424 decreased urine uric acid level "abnormally low amount in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:anna]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0011584 increased alkaline phosphatase activity "greater ability to catalyze the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum" [GO:0004035]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0013285 abnormal renal filtration "any anomaly in the renal system process in which fluid circulating through the body is filtered through a barrier system" [GO:0097205]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0014143 decreased body fat mass "decreased physical bulk or volume of fat in the whole body" [MGI:csmith]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0030106 small incus "reduced size of the anvil-shaped, central bone of the three auditory ossicles which articulates with the head of the malleus anteromedially and the stapes inferomedially" [https://radiopaedia.org/articles/incus]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

 MP:0030123 small middle ear ossicles "reduced size of the three bones of the middle ear" [MGI:anna]
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Allelic Composition: Afg3l1tm1.1Arte/Afg3l1tm1.1Arte,Afg3l2tm1Arte/Afg3l2tm1Arte,Gt(ROSA)26Sortm1Lrsn/Gt(ROSA)26Sor+,Tg(Plp1-cre/ERT)3Pop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000016763 Q6NZL8 / Scube1 / signal peptide, CUB domain, EGF-like 1 / Q8IWY4* / signal peptide, CUB domain and EGF like domain containing 1*  / -
 ENSMUSG00000017737 Mmp9 / P41245 / Matrix metalloproteinase-9 / P14780* / matrix metallopeptidase 9*  / reaction
 ENSMUSG00000031740 Mmp2 / P33434 / 72 kDa type IV collagenase PEX / P08253* / matrix metallopeptidase 2*  / reaction
 ENSMUSG00000038677 Q66PY1 / Scube3 / Signal peptide, CUB and EGF-like domain-containing protein 3 / Q8IX30* / signal peptide, CUB domain and EGF like domain containing 3*  / -






 

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