ENSMUSG00000031740


Mus musculus

Features
Gene ID: ENSMUSG00000031740
  
Biological name :Mmp2
  
Synonyms : 72 kDa type IV collagenase PEX / Mmp2 / P33434
  
Possible biological names infered from orthology : matrix metallopeptidase 2 / P08253
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C5
Gene start: 92827291
Gene end: 92853420
  
Corresponding Affymetrix probe sets: 10573924 (MoGene1.0st)   1416136_at (Mouse Genome 430 2.0 Array)   1439364_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034187
Ensembl peptide - ENSMUSP00000147838
NCBI entrez gene - 17390     See in Manteia.
MGI - MGI:97009
RefSeq - XM_006530751
RefSeq - NM_008610
RefSeq Peptide - NP_032636
swissprot - P33434
swissprot - Q3UG07
swissprot - A0A1B0GS88
Ensembl - ENSMUSG00000031740
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp2ENSDARG00000017676Danio rerio
 MMP2ENSGALG00000003580Gallus gallus
 MMP2ENSG00000087245Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp9 / P41245 / Matrix metalloproteinase-9 / P14780* / matrix metallopeptidase 9*ENSMUSG0000001773748
Mmp19 / Q9JHI0 / Matrix metalloproteinase-19 / Q99542* / matrix metallopeptidase 19*ENSMUSG0000002535523
Mmp28 / matrix metallopeptidase 28 (epilysin) / Q9H239* / matrix metallopeptidase 28*ENSMUSG0000002068221
Mmp21 / Q8K3F2 / matrix metallopeptidase 21 / Q8N119*ENSMUSG0000003098121
Mmp23 / O88676 / Matrix metalloproteinase-23 Matrix metalloproteinase-23, soluble form / MMP23B* / O75900* / matrix metallopeptidase 23B*ENSMUSG0000002906115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000562  Fibronectin type II domain
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR013806  Kringle-like fold
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR028708  72kDa type IV collagenase
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036366  PGBD superfamily
 IPR036375  Hemopexin-like domain superfamily
 IPR036943  Fibronectin type II domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001666 response to hypoxia IDA
 biological_processGO:0001955 blood vessel maturation IGI
 biological_processGO:0001957 intramembranous ossification IGI
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007566 embryo implantation IDA
 biological_processGO:0030574 collagen catabolic process IMP
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0045089 positive regulation of innate immune response IDA
 biological_processGO:0048705 skeletal system morphogenesis IGI
 biological_processGO:0060325 face morphogenesis IGI
 biological_processGO:0060346 bone trabecula formation IGI
 biological_processGO:0071230 cellular response to amino acid stimulus IDA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030017 sarcomere IDA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity ISO
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0000097 short maxilla "reduced length of the upper jaw bone" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Tg(KRT14-HPV16)wt1Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * FVB/N

 MP:0000445 short snout "reduced length of the anterior facial part of the muzzle" [J:53370]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0000736 delayed muscle development "late onset of the induction and/or differentiation of skeletal muscle" [J:18048]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0000761 thin diaphragm muscle "reduced thickness of the diaphragm muscle" [MGI:CLS, J:60159]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kdm6atm1c(EUCOMM)Wtsi/Kdm6atm1c(EUCOMM)Wtsi,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: either: (involves: C57BL/6 * CBA * CD-1) or (involves: 129 * C57BL/6 * CBA * CD-1)

 MP:0002113 abnormal skeleton development "anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp3tm1Mrl/Mmp3tm1Mrl,Timp1tm1Pds/Timp1tm1Pds
Genetic Background: involves: C57BL/6

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0002993 arthritis "joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0003434 resistance to induced choroidal neovascularization "reduction or absence of growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma)" [J:82604, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0003797 abnormal compact bone morphology "structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0003840 abnormal coronal suture morphology "malformation of the articulation between the parietal bones and the frontal bone" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0003841 abnormal lambdoidal suture morphology "malformation of the articulation of the parietal bones and the occipital bone" [Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0003843 abnormal sagittal suture morphology "malformation of the articulation between the parietal bones" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0004989 decreased osteoblast cell number "reduction in the number of the bone-forming cells, which normally form an osseous matrix (osteoid) in which they become enclosed as an osteocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Drd2tm1Mok/Drd2tm1Mok
Genetic Background: involves: 129S/SvEv

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Htttm2Detl/Htt+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0006433 abnormal articular cartilage morphology "any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone" [ISBN:0-8036-0655-9 "Taber s Cyclopedic Medical Dictionary", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0009866 abnormal aorta wall morphology "any structural anomaly of the part of the aorta that encloses the luminal space" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Timp3tm1Osya/Timp3tm1Osya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009870 abnormal abdominal aorta morphology "any structural anomaly of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, and supplies oxygenated blood to all of the abdominal and pelvic organs and the legs" [http://www.medterms.com "MedicineNet.com"]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Timp3tm1Osya/Timp3tm1Osya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010139 aortitis "inflammation of the aorta" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Timp3tm1Osya/Timp3tm1Osya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010659 abdominal aorta aneurysm "a protruding sac formed by the dilation of the wall of the part of the descending aorta that begins at the diaphragm and continues to the point of the common iliac arteries, resulting from a weakening of the vessel wall" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito,Timp3tm1Osya/Timp3tm1Osya
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab,Shhtm2Chg/Shh+,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0030166 increased inner canthal distance "increased distance between the inner corners (medial canthi) of the eyes where the eyelids meet; may be present without or with ocular hypertelorism (where interpupillary distance is increased)" [HP:0000506, https://en.wikipedia.org/wiki/Telecanthus, PMID:19125427]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0030189 broad snout "increased width of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
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Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0030360 coronal suture sclerosis "an increased density in the coronal suture following obliteration" [MGI:anna]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0030361 lambdoid suture sclerosis "an increased density in the lambdoid suture following obliteration" [MGI:anna]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0030362 sagittal suture sclerosis "an increased density in the sagittal suture following obliteration" [MGI:anna]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017466 Timp2 / tissue inhibitor of metalloproteinase 2 / P16035* / TIMP metallopeptidase inhibitor 2*  / complex / reaction
 ENSMUSG00000018623 Mmp7 / matrix metallopeptidase 7 / P09237*  / reaction
 ENSMUSG00000010311 Optc / opticin isoform 4 / Q9UBM4* / opticin*  / reaction
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / reaction
 ENSMUSG00000020053 Igf1 / P05017 / Insulin-like growth factor I / P05019* / insulin like growth factor 1*  / reaction
 ENSMUSG00000020427 Igfbp3 / P47878 / Insulin-like growth factor-binding protein 3 / P17936*  / reaction
 ENSMUSG00000024598 Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*  / reaction
 ENSMUSG00000038677 Q66PY1 / Scube3 / Signal peptide, CUB and EGF-like domain-containing protein 3 / Q8IX30* / signal peptide, CUB domain and EGF like domain containing 3*  / reaction
 ENSMUSG00000019929 Dcn / P28654 / Decorin / P07585*  / reaction
 ENSMUSG00000046070 Igfals / insulin-like growth factor binding protein, acid labile subunit / P35858*  / reaction
 ENSMUSG00000041620 Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*  / reaction
 ENSMUSG00000048583 Igf2 / P09535 / Insulin-like growth factor II Insulin-like growth factor II Preptin / P01344* / insulin like growth factor 2*  / reaction
 ENSMUSG00000000957 Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*  / reaction / complex






 

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