ENSDARG00000017676


Danio rerio

Features
Gene ID: ENSDARG00000017676
  
Biological name :mmp2
  
Synonyms : matrix metallopeptidase 2 / mmp2
  
Possible biological names infered from orthology : 72 kDa type IV collagenase PEX / P08253 / P33434
  
Species: Danio rerio
  
Chr. number: 7
Strand: -1
Band:
Gene start: 35410050
Gene end: 35432901
  
Corresponding Affymetrix probe sets: Dr.2408.1.A1_at (Zebrafish Array)   Dr.2408.2.S1_at (Zebrafish Array)   NM_198067_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000006091
NCBI entrez gene - 337179     See in Manteia.
RefSeq - NM_198067
RefSeq Peptide - NP_932333
swissprot - Q6DG10
ZFIN ID - ZDB-GENE-030131-9123
Ensembl - ENSDARG00000017676
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MMP2ENSGALG00000003580Gallus gallus
 MMP2ENSG00000087245Homo sapiens
 Mmp2ENSMUSG00000031740Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mmp9 / matrix metallopeptidase 9 / P14780* / P41245* / Matrix metalloproteinase-9 *ENSDARG0000004281649
mmp19 / matrix metallopeptidase 19 / Q99542* / Q9JHI0* / Matrix metalloproteinase-19 *ENSDARG0000009155723
mmp28 / matrix metallopeptidase 28 / Q9H239* / matrix metallopeptidase 28 (epilysin)*ENSDARG0000005902922
mmp21 / A0A0N9E2K8 / matrix metallopeptidase 21 / Q8N119*ENSDARG0000011249519
mmp23bb / matrix metallopeptidase 23bbENSDARG0000000982515
MMP23B / matrix metallopeptidase 23B / O75900*ENSDARG0000004307914
CABZ01029422.1ENSDARG0000011643810


Protein motifs (from Interpro)
Interpro ID Name
 IPR000562  Fibronectin type II domain
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR013806  Kringle-like fold
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028708  72kDa type IV collagenase
 IPR033739  Peptidase M10A, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001945 lymph vessel development IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0031290 retinal ganglion cell axon guidance IGI
 biological_processGO:0035701 hematopoietic stem cell migration IMP
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cells


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism edematous , abnormal
whole organism anterior region has extra parts of type hematopoietic multipotent progenitor cell , abnormal
whole organism posterior region has fewer parts of type hematopoietic multipotent progenitor cell , abnormal
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 ZFA:0001114 head head morphology , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
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 ZFA:0001345 interrenal gland interrenal gland animal organ morphogenesis process quality , abnormal
interrenal gland epithelial to mesenchymal transition decreased occurrence , abnormal
interrenal gland position , abnormal
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 ZFA:0005023 hematopoietic system hematopoietic system posterior region decreased amount , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta hematopoietic multipotent progenitor cell spatial pattern , abnormal
ventral wall of dorsal aorta increased amount , abnormal
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 ZFA:0005110 thoracic duct thoracic duct hypoplastic , abnormal
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 ZFA:0005802 interrenal angiogenic sprout interrenal angiogenic sprout decreased length , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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