ENSDARG00000042816


Danio rerio

Features
Gene ID: ENSDARG00000042816
  
Biological name :mmp9
  
Synonyms : matrix metallopeptidase 9 / mmp9
  
Possible biological names infered from orthology : Matrix metalloproteinase-9 / P14780 / P41245
  
Species: Danio rerio
  
Chr. number: 8
Strand: 1
Band:
Gene start: 24281512
Gene end: 24295947
  
Corresponding Affymetrix probe sets: Dr.967.1.S1_at (Zebrafish Array)   NM_213123_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000062844
NCBI entrez gene - 406397     See in Manteia.
RefSeq - NM_213123
RefSeq Peptide - NP_998288
swissprot - F1QC76
ZFIN ID - ZDB-GENE-040426-2132
Ensembl - ENSDARG00000042816
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MMP9ENSGALG00000006992Gallus gallus
 MMP9ENSG00000100985Homo sapiens
 Mmp9ENSMUSG00000017737Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mmp2 / matrix metallopeptidase 2 / P08253* / P33434* / 72 kDa type IV collagenase PEX*ENSDARG0000001767647
mmp19 / matrix metallopeptidase 19 / Q99542* / Q9JHI0* / Matrix metalloproteinase-19 *ENSDARG0000009155722
mmp28 / matrix metallopeptidase 28 / Q9H239* / matrix metallopeptidase 28 (epilysin)*ENSDARG0000005902922
mmp21 / A0A0N9E2K8 / matrix metallopeptidase 21 / Q8N119*ENSDARG0000011249518
MMP23B / matrix metallopeptidase 23B / O75900*ENSDARG0000004307913
mmp23bb / matrix metallopeptidase 23bbENSDARG0000000982513
CABZ01029422.1ENSDARG000001164389


Protein motifs (from Interpro)
Interpro ID Name
 IPR000562  Fibronectin type II domain
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR013806  Kringle-like fold
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028688  Matrix metalloproteinase-9
 IPR033739  Peptidase M10A, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0002633 positive regulation of granuloma formation IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0009617 response to bacterium IMP
 biological_processGO:0030199 collagen fibril organization IMP
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0031101 fin regeneration IMP
 biological_processGO:0033334 fin morphogenesis IMP
 biological_processGO:0035701 hematopoietic stem cell migration IMP
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0060429 epithelium development IGI
 biological_processGO:0090594 inflammatory response to wounding IMP
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000105 epidermis epidermis basement membrane wholeness , ameliorated
Show

 ZFA:0000112 gut gut blood increased amount , abnormal
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 ZFA:0001058 caudal fin caudal fin neutrophil increased amount , ameliorated
Show

 ZFA:0001114 head head morphology , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton morphology , abnormal
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 ZFA:0001261 ventricular system ventricular system macrophage migration decreased occurrence , abnormal
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 ZFA:0001269 regenerating fin regenerating fin caudal fin lepidotrichium increased length , abnormal
regenerating fin decreased length , abnormal
regenerating fin fibrillar collagen trimer thickness , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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