ENSMUSG00000017737


Mus musculus

Features
Gene ID: ENSMUSG00000017737
  
Biological name :Mmp9
  
Synonyms : Matrix metalloproteinase-9 / Mmp9 / P41245
  
Possible biological names infered from orthology : matrix metallopeptidase 9 / P14780
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 164940780
Gene end: 164955850
  
Corresponding Affymetrix probe sets: 10478633 (MoGene1.0st)   1416298_at (Mouse Genome 430 2.0 Array)   1448291_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120628
Ensembl peptide - ENSMUSP00000017881
NCBI entrez gene - 17395     See in Manteia.
MGI - MGI:97011
RefSeq - NM_013599
RefSeq - XM_006498861
RefSeq Peptide - NP_038627
swissprot - A2A5K8
swissprot - P41245
Ensembl - ENSMUSG00000017737
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp9ENSDARG00000042816Danio rerio
 MMP9ENSGALG00000006992Gallus gallus
 MMP9ENSG00000100985Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp2 / P33434 / 72 kDa type IV collagenase PEX / P08253* / matrix metallopeptidase 2*ENSMUSG0000003174043
Mmp19 / Q9JHI0 / Matrix metalloproteinase-19 / Q99542* / matrix metallopeptidase 19*ENSMUSG0000002535521
Mmp28 / matrix metallopeptidase 28 (epilysin) / Q9H239* / matrix metallopeptidase 28*ENSMUSG0000002068219
Mmp21 / Q8K3F2 / matrix metallopeptidase 21 / Q8N119*ENSMUSG0000003098118
Mmp23 / O88676 / Matrix metalloproteinase-23 Matrix metalloproteinase-23, soluble form / MMP23B* / O75900* / matrix metallopeptidase 23B*ENSMUSG0000002906113


Protein motifs (from Interpro)
Interpro ID Name
 IPR000562  Fibronectin type II domain
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR006970  PT repeat
 IPR013806  Kringle-like fold
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028688  Matrix metalloproteinase-9
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily
 IPR036943  Fibronectin type II domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0006508 proteolysis ISO
 biological_processGO:0007566 embryo implantation IDA
 biological_processGO:0030198 extracellular matrix organization IMP
 biological_processGO:0030574 collagen catabolic process IDA
 biological_processGO:0034614 cellular response to reactive oxygen species IEA
 biological_processGO:0035987 endodermal cell differentiation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0045742 positive regulation of epidermal growth factor receptor signaling pathway IEA
 biological_processGO:0050900 leukocyte migration IEA
 biological_processGO:0051549 positive regulation of keratinocyte migration IEA
 biological_processGO:0071276 cellular response to cadmium ion IEA
 biological_processGO:0090200 positive regulation of release of cytochrome c from mitochondria IEA
 biological_processGO:1900122 positive regulation of receptor binding IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:2001243 negative regulation of intrinsic apoptotic signaling pathway IEA
 biological_processGO:2001258 negative regulation of cation channel activity IEA
 biological_processGO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004175 endopeptidase activity IEA
 molecular_functionGO:0004222 metalloendopeptidase activity ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008237 metallopeptidase activity IDA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by SCF-KIT
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EPH-ephrin mediated repulsion of cells
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0000067 osteopetrosis "excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0000133 abnormal long bone metaphysis morphology "malformed conical section of bone between the epiphysis and diaphysis of the long bones" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Dicer1tm1Dli/Dicer1tm1Dli,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129 * C57BL/6 * DBA/2

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0000229 abnormal megakaryocyte differentiation "atypical process of formation and development these very large bone marrow cells which release mature platelets" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: RhoR3/RhoR3
Genetic Background: C57BL/6J-RhoR3

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Clocktm1.1Rep/Clocktm1.1Rep
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Serp1tm1Hori/Serp1tm1Hori
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: FVB.129S6-Mmp9tm1Tvu

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar
Genetic Background: B6.129S-Mmp13tm1Jdar

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
Show

Allelic Composition: Parp1tm1Zqw/Parp1tm1Zqw
Genetic Background: 129S-Parp1tm1Zqw/J

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * Black Swiss * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb
Genetic Background: involves: 129S2/SvPas

 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * Black Swiss * FVB/N

 MP:0001602 impaired myelopoiesis "atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: RhoR3/RhoR3
Genetic Background: C57BL/6J-RhoR3

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: RhoR3/RhoR3
Genetic Background: C57BL/6J-RhoR3

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002052 decreased tumor incidence "less than the expected number of abnormal growths in a specific population" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: B6.129S-Rag2tm1Fwa Mmp9tm1Tvu

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Tg(KRT14-HPV16)wt1Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * FVB/N

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Mmp9tm1Tvu/Mmp9+
Genetic Background: B10.Cg-Mmp9tm1Tvu Dmdmdx

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Dmdmdx/Dmdmdx,Mmp9tm1Tvu/Mmp9+
Genetic Background: B10.Cg-Mmp9tm1Tvu Dmdmdx

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * Black Swiss * FVB/N

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0002503 abnormal histamine physiology "functional anomaly of this amine that is involved in local immune response, in regulating physiological function in the gut, and that acts as a neurotransmitter" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Psen1tm1Lpr/Psen1tm1Lpr,Tg(Thy1-APPSL)28Lpr/0
Genetic Background: either: 129/Sv or (involves: 129/Sv * C57BL/6)

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0002839 susceptibility to dystrophic cardiac calcinosis "more likely to be stricken by dystrophic cardiac calcinosis" [J:76777, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002933 joint inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the joints" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002936 joint swelling "enlargement of the joints, usually due to an accumulation of fluid" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0003038 decreased infarction size "decreased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Gadd45atm1Ajf/Gadd45atm1Ajf
Genetic Background: either: (involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6)

Allelic Composition: Mmp9tm1Amr/Mmp9+
Genetic Background: B6.Cg-Mmp9tm1Amr

 MP:0003043 hypoalgesia "decreased sensation to painful stimuli that may follow damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: FVB.Cg-Mmp9tm1Tvu/J

 MP:0003055 abnormal epiphyseal plate morphology "malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6

 MP:0003072 abnormal metatarsal bone morphology "anomaly in the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phlanges" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0003434 resistance to induced choroidal neovascularization "reduction or absence of growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma)" [J:82604, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp2tm1Ito/Mmp2tm1Ito
Genetic Background: involves: 129P2/OlaHsd

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0003448 altered tumor morphology "changes in the expected pathology for a given tumor type compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Faslgld/Faslgld
Genetic Background: involves: C3H/HeJ * C57BL/6

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * FVB/N

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: FVB.Cg-Mmp9tm1Tvu/J

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: FVB.Cg-Mmp9tm1Tvu/J

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: FVB.129S6-Mmp9tm1Tvu

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

Allelic Composition: Dmdmdx/Dmdmdx,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: B10.Cg-Mmp9tm1Tvu Dmdmdx

Allelic Composition: Dmdmdx/Dmdmdx,Mmp9tm1Tvu/Mmp9+
Genetic Background: B10.Cg-Mmp9tm1Tvu Dmdmdx

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004351 short humerus "reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hspg2tm1Ref/Hspg2tm1Ref,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MipHfi/MipHfi
Genetic Background: involves: 101 * C3H

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adgrv1tm1Pwh/Adgrv1tm1Pwh
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * CD-1

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: FVB.Cg-Mmp9tm1Tvu/J

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * Black Swiss * FVB/N

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Chat/Slc18a3tm1.1Vpra/Slc18a3+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0005362 abnormal Langerhans cell physiology "atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0005600 increased ventricle muscle contractility "greater thant the normal ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Fgf10tm1Wss/Fgf10tm1Wss
Genetic Background: involves: 129X1/SvJ

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fbn1Tsk/Fbn1+
Genetic Background: B6.Cg-Fbn1Tsk +/+ Bloc1s6pa/JKcc

 MP:0006059 decreased susceptibility to ischemic brain injury "decreased lesion size following loss of circulation in a region of the brain; may be induced or spontaneous" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0006072 abnormal retinal apoptosis "increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0006278 aortic aneurysm "protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
Show

Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hspg2tm1Ref/Hspg2tm1Ref,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0006399 abnormal long bone epiphyseal ossification zone morphology "any anomaly in the structure of the layer of the epiphyseal plate where new bone matrix is deposited" [CALnet tutorial:http://137.222.110.150/calnet/Introanat/Introanat.htm, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0008090 increased T-helper 2 cell number "greater number of the subset of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008160 increased diameter of humerus "increased width of the cross-sectional distance that extends from one lateral edge of the humerus, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hspg2tm1Ref/Hspg2tm1Ref,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0008246 abnormal leukocyte morphology "any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: FVB.129S6-Mmp9tm1Tvu

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: FVB.Cg-Mmp9tm1Tvu/J

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0008575 increased circulating interferon-beta level "increase in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008594 decreased circulating interleukin-10 level "reduction in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Fbn1Tsk/Fbn1+
Genetic Background: B6.Cg-Fbn1Tsk +/+ Bloc1s6pa/JKcc

 MP:0008672 increased interleukin-13 secretion "increase in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0008702 increased interleukin-5 secretion "increase in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Catb/Cat+
Genetic Background: Not Specified

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0009427 increased tibialis anterior weight "increase in the weight of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: FVB.Cg-Mmp9tm1Tvu/J

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * Black Swiss * FVB/N

 MP:0009584 decreased keratinocyte proliferation "reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Tg(KRT14-HPV16)wt1Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * FVB/N

 MP:0009660 abnormal induced retinal neovascularization "any anomaly in the response to conditions which induce the pathological growth of vessels into the retina" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009704 skin squamous cell carcinoma "a skin carcinoma derived from stratified squamous epithelium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Tg(KRT14-HPV16)wt1Dh/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2 * FVB/N

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * CD-1

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: FVB.129S6-Mmp9tm1Tvu

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: FVB.Cg-Mmp9tm1Tvu/J

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009808 reduced oligodendrocyte number "significantly fewer than the expected number of cells of the central nervous system that form the insulating myelin sheath of axons in the CNS are present" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0009814 increased prostaglandin level "increase in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ltb/Tnf/Ltatm1Dvk/Ltb/Tnf/Ltatm1Dvk
Genetic Background: involves: C57BL/6

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Tg(MMTV-PyVT)634Mul/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd3tm1Nat/Fzd3tm1Nat,Fzd6tm1Nat/Fzd6tm1Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011348 abnormal renal glomerulus basement membrane morphology "any structural anomaly of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule; it is a fusion of the endothelial cell and podocyte basal laminas and acts as a physical barrier and an ion-selective filter" [MGI:anna]
Show

Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0011409 increased renal glomerulus basement membrane thickness "increased width of the layer of extracellular matrix that lies between the endothelium of the glomerular capillaries and the podocytes of the inner or visceral layer of the Bowman capsule" [MGI:anna]
Show

Allelic Composition: Col4a3tm1Jhm/Col4a3tm1Jhm,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ

 MP:0013237 abnormal skeletal muscle regeneration "anomaly in the ability to repair skeletal muscle after injury or disease" [MGI:csmith]
Show

Allelic Composition: Dmdmdx/Dmdmdx,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: B10.Cg-Mmp9tm1Tvu Dmdmdx

Allelic Composition: Dmdmdx/Dmdmdx,Mmp9tm1Tvu/Mmp9+
Genetic Background: B10.Cg-Mmp9tm1Tvu Dmdmdx

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001131 Timp1 / P12032 / Metalloproteinase inhibitor 1 / P01033* / TIMP metallopeptidase inhibitor 1*  / complex / reaction
 ENSMUSG00000038677 Q66PY1 / Scube3 / Signal peptide, CUB and EGF-like domain-containing protein 3 / Q8IX30* / signal peptide, CUB domain and EGF like domain containing 3*  / reaction
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / reaction
 ENSMUSG00000000303 Cdh1 / cadherin 1 / P12830*  / reaction
 ENSMUSG00000019966 Kitl / P20826 / Kit ligand Soluble KIT ligand / KITLG* / P21583* / KIT ligand*  / reaction
 ENSMUSG00000024598 Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*  / reaction
 ENSMUSG00000041620 Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr