ENSMUSG00000020682


Mus musculus

Features
Gene ID: ENSMUSG00000020682
  
Biological name :Mmp28
  
Synonyms : matrix metallopeptidase 28 (epilysin) / Mmp28
  
Possible biological names infered from orthology : matrix metallopeptidase 28 / Q9H239
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 83440768
Gene end: 83463071
  
Corresponding Affymetrix probe sets: 10389177 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000021020
Ensembl peptide - ENSMUSP00000099498
Ensembl peptide - ENSMUSP00000103772
Ensembl peptide - ENSMUSP00000112566
NCBI entrez gene - 118453     See in Manteia.
MGI - MGI:2153062
RefSeq - NM_172797
RefSeq - NM_001320300
RefSeq - NM_080453
RefSeq Peptide - NP_001307229
RefSeq Peptide - NP_536701
RefSeq Peptide - NP_766385
swissprot - Q5SSG2
swissprot - Q8BG29
swissprot - Q8CGV5
swissprot - Q8CGV8
Ensembl - ENSMUSG00000020682
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp28ENSDARG00000059029Danio rerio
 MMP28ENSGALG00000002081Gallus gallus
 MMP28ENSG00000271447Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp19 / Q9JHI0 / Matrix metalloproteinase-19 / Q99542* / matrix metallopeptidase 19*ENSMUSG0000002535533
Mmp21 / Q8K3F2 / matrix metallopeptidase 21 / Q8N119*ENSMUSG0000003098128
Mmp2 / P33434 / 72 kDa type IV collagenase PEX / P08253* / matrix metallopeptidase 2*ENSMUSG0000003174027
Mmp9 / P41245 / Matrix metalloproteinase-9 / P14780* / matrix metallopeptidase 9*ENSMUSG0000001773726
Mmp23 / O88676 / Matrix metalloproteinase-23 Matrix metalloproteinase-23, soluble form / MMP23B* / O75900* / matrix metallopeptidase 23B*ENSMUSG0000002906118


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018487  Hemopexin-like repeats
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028735  Matrix metalloproteinase-28
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0010760 negative regulation of macrophage chemotaxis IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0004222 metalloendopeptidase activity ISO
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Csf3rtm3Link/Csf3rtm3Link
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Csf3rtm3Link/Csf3rtm3Link
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Csf3rtm3Link/Csf3rtm3Link
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Csf3rtm3Link/Csf3rtm3Link
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Csf3rtm3Link/Csf3rtm3Link
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Csf3rtm3Link/Csf3rtm3Link
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
Show

Allelic Composition: Csf3rtm3Link/Csf3rtm3Link
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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