ENSMUSG00000025355


Mus musculus

Features
Gene ID: ENSMUSG00000025355
  
Biological name :Mmp19
  
Synonyms : Matrix metalloproteinase-19 / Mmp19 / Q9JHI0
  
Possible biological names infered from orthology : matrix metallopeptidase 19 / Q99542
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 128790910
Gene end: 128800824
  
Corresponding Affymetrix probe sets: 10367400 (MoGene1.0st)   1421976_at (Mouse Genome 430 2.0 Array)   1421977_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026411
Ensembl peptide - ENSMUSP00000151437
NCBI entrez gene - 58223     See in Manteia.
MGI - MGI:1927899
RefSeq - NM_021412
RefSeq - NM_001164197
RefSeq Peptide - NP_001157669
RefSeq Peptide - NP_067387
swissprot - Q2KHP2
swissprot - Q3UW97
swissprot - Q9JHI0
Ensembl - ENSMUSG00000025355
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp19ENSDARG00000091557Danio rerio
 MMP19ENSG00000123342Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp28 / matrix metallopeptidase 28 (epilysin) / Q9H239* / matrix metallopeptidase 28*ENSMUSG0000002068232
Mmp2 / P33434 / 72 kDa type IV collagenase PEX / P08253* / matrix metallopeptidase 2*ENSMUSG0000003174029
Mmp9 / P41245 / Matrix metalloproteinase-9 / P14780* / matrix metallopeptidase 9*ENSMUSG0000001773729
Mmp21 / Q8K3F2 / matrix metallopeptidase 21 / Q8N119*ENSMUSG0000003098127
Mmp23 / O88676 / Matrix metalloproteinase-23 Matrix metalloproteinase-23, soluble form / MMP23B* / O75900* / matrix metallopeptidase 23B*ENSMUSG0000002906120


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028724  Matrix metalloproteinase-19
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001542 ovulation from ovarian follicle IEA
 biological_processGO:0001554 luteolysis IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0051591 response to cAMP IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0004222 metalloendopeptidase activity ISS
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Prxtm1Brp/Prxtm1Brp
Genetic Background: involves: 129P2/OlaHsd

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prxtm1Brp/Prxtm1Brp
Genetic Background: involves: 129P2/OlaHsd

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Prxtm1Brp/Prxtm1Brp
Genetic Background: involves: 129P2/OlaHsd

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oca2p-dn/Oca2p-dn
Genetic Background: Not Specified

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Prxtm1Brp/Prxtm1Brp
Genetic Background: involves: 129P2/OlaHsd

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prxtm1Brp/Prxtm1Brp
Genetic Background: involves: 129P2/OlaHsd

 MP:0005334 abnormal fat pad "malformed or aberrant size of the encapsulated adipose tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-dn/Oca2p-dn
Genetic Background: Not Specified

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prxtm1Brp/Prxtm1Brp
Genetic Background: involves: 129P2/OlaHsd

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-dn/Oca2p-dn
Genetic Background: Not Specified

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Oca2p-dn/Oca2p-dn
Genetic Background: Not Specified

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prxtm1Brp/Prxtm1Brp
Genetic Background: involves: 129P2/OlaHsd

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prxtm1Brp/Prxtm1Brp
Genetic Background: involves: 129P2/OlaHsd

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Prxtm1Brp/Prxtm1Brp
Genetic Background: involves: 129P2/OlaHsd

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Oca2p-dn/Oca2p-dn
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000005397 Nid1 / P10493 / Nidogen-1 / P14543*  / reaction






 

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