ENSMUSG00000005397


Mus musculus

Features
Gene ID: ENSMUSG00000005397
  
Biological name :Nid1
  
Synonyms : Nid1 / Nidogen-1 / P10493
  
Possible biological names infered from orthology : P14543
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A1
Gene start: 13437551
Gene end: 13512269
  
Corresponding Affymetrix probe sets: 10403584 (MoGene1.0st)   1416808_at (Mouse Genome 430 2.0 Array)   1441519_at (Mouse Genome 430 2.0 Array)   1448469_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000005532
NCBI entrez gene - 18073     See in Manteia.
MGI - MGI:97342
RefSeq - NM_010917
RefSeq Peptide - NP_035047
swissprot - P10493
Ensembl - ENSMUSG00000005397
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nid1aENSDARG00000068710Danio rerio
 nid1bENSDARG00000103129Danio rerio
 NID1ENSGALG00000042079Gallus gallus
 NID1ENSG00000116962Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nid2 / O88322 / Nidogen-2 / Q14112*ENSMUSG0000002180643
Egf / P01132 / Mus musculus epidermal growth factor (Egf), transcript variant 3, mRNA. / P01133* / epidermal growth factor*ENSMUSG0000002801713


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000716  Thyroglobulin type-1
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR003886  NIDO domain
 IPR006605  G2 nidogen/fibulin G2F
 IPR009017  Green fluorescent protein
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024731  EGF domain
 IPR026823  Complement Clr-like EGF domain
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IDA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IDA
 biological_processGO:0030198 extracellular matrix organization IDA
 biological_processGO:0032836 glomerular basement membrane development IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane TAS
 cellular_componentGO:0005605 basal lamina IDA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0071944 cell periphery IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0043236 laminin binding IEA
 molecular_functionGO:0043237 laminin-1 binding IDA
 molecular_functionGO:0043394 proteoglycan binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IDA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Laminin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004272 abnormal basement membrane morphology "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220]
Show

Allelic Composition: Sox3tm1.1Lja/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fcgr1tm1Jgjw/Fcgr1tm1Jgjw
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025355 Mmp19 / Q9JHI0 / Matrix metalloproteinase-19 / Q99542* / matrix metallopeptidase 19*  / reaction






 

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