ENSG00000116962


Homo sapiens

Features
Gene ID: ENSG00000116962
  
Biological name :NID1
  
Synonyms : NID1 / nidogen 1 / P14543
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q42.3
Gene start: 235975830
Gene end: 236065162
  
Corresponding Affymetrix probe sets: 1561082_at (Human Genome U133 Plus 2.0 Array)   202007_at (Human Genome U133 Plus 2.0 Array)   202008_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000264187
Ensembl peptide - ENSP00000355554
NCBI entrez gene - 4811     See in Manteia.
OMIM - 131390
RefSeq - XM_011544195
RefSeq - NM_002508
RefSeq Peptide - NP_002499
swissprot - P14543
Ensembl - ENSG00000116962
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nid1aENSDARG00000068710Danio rerio
 nid1bENSDARG00000103129Danio rerio
 NID1ENSGALG00000042079Gallus gallus
 Nid1ENSMUSG00000005397Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NID2 / Q14112 / nidogen 2ENSG0000008730343
EGF / P01133 / epidermal growth factorENSG0000013879815
LRP5L / A4QPB2 / LDL receptor related protein 5 likeENSG000001000686


Protein motifs (from Interpro)
Interpro ID Name
 IPR000033  LDLR class B repeat
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000716  Thyroglobulin type-1
 IPR000742  EGF-like domain
 IPR001881  EGF-like calcium-binding domain
 IPR003886  NIDO domain
 IPR006605  G2 nidogen/fibulin G2F
 IPR009017  Green fluorescent protein
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR013032  EGF-like, conserved site
 IPR018097  EGF-like calcium-binding, conserved site
 IPR024731  EGF domain
 IPR026823  Complement Clr-like EGF domain
 IPR036857  Thyroglobulin type-1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0032836 glomerular basement membrane development IEA
 biological_processGO:0071711 basement membrane organization TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005605 basal lamina IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0031012 extracellular matrix ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071944 cell periphery IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0043236 laminin binding IDA
 molecular_functionGO:0043237 laminin-1 binding IEA
 molecular_functionGO:0043394 proteoglycan binding IPI
 molecular_functionGO:0050840 extracellular matrix binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Laminin interactions


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000102996 MMP15 / P51511 / matrix metallopeptidase 15  / reaction
 ENSG00000142798 HSPG2 / P98160 / heparan sulfate proteoglycan 2  / complex / reaction
 ENSG00000197561 ELANE / P08246 / elastase, neutrophil expressed  / reaction
 ENSG00000137673 MMP7 / P09237 / matrix metallopeptidase 7  / reaction
 ENSG00000157227 MMP14 / P50281 / matrix metallopeptidase 14  / reaction
 ENSG00000149968 MMP3 / P08254 / matrix metallopeptidase 3  / reaction
 ENSG00000123342 MMP19 / Q99542 / matrix metallopeptidase 19  / reaction
 ENSG00000196611 MMP1 / P03956 / matrix metallopeptidase 1  / reaction
 ENSG00000100985 MMP9 / P14780 / matrix metallopeptidase 9  / reaction
 ENSG00000262406 MMP12 / P39900 / matrix metallopeptidase 12  / reaction






 

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