ENSG00000157227


Homo sapiens

Features
Gene ID: ENSG00000157227
  
Biological name :MMP14
  
Synonyms : matrix metallopeptidase 14 / MMP14 / P50281
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q11.2
Gene start: 22836557
Gene end: 22849027
  
Corresponding Affymetrix probe sets: 160020_at (Human Genome U133 Plus 2.0 Array)   202827_s_at (Human Genome U133 Plus 2.0 Array)   202828_s_at (Human Genome U133 Plus 2.0 Array)   217279_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000446989
Ensembl peptide - ENSP00000450323
Ensembl peptide - ENSP00000308208
NCBI entrez gene - 4323     See in Manteia.
OMIM - 600754
RefSeq - NM_004995
RefSeq Peptide - NP_004986
swissprot - P50281
swissprot - F8VP90
swissprot - F8W1B7
Ensembl - ENSG00000157227
  
Related genetic diseases (OMIM): 277950 - ?Winchester syndrome, 277950
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp14aENSDARG00000002235Danio rerio
 mmp14bENSDARG00000008388Danio rerio
 Mmp14ENSMUSG00000000957Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP15 / P51511 / matrix metallopeptidase 15ENSG0000010299659
MMP16 / P51512 / matrix metallopeptidase 16ENSG0000015610355
MMP24 / Q9Y5R2 / matrix metallopeptidase 24ENSG0000012596654
MMP25 / Q9NPA2 / matrix metallopeptidase 25ENSG0000000851635
MMP17 / Q9ULZ9 / matrix metallopeptidase 17ENSG0000019859833
MMP3 / P08254 / matrix metallopeptidase 3ENSG0000014996832
MMP13 / P45452 / matrix metallopeptidase 13ENSG0000013774531
MMP1 / P03956 / matrix metallopeptidase 1ENSG0000019661131
MMP12 / P39900 / matrix metallopeptidase 12ENSG0000026240631
MMP10 / P09238 / matrix metallopeptidase 10ENSG0000016667030
MMP20 / O60882 / matrix metallopeptidase 20ENSG0000013767430
MMP8 / P22894 / matrix metallopeptidase 8ENSG0000011811330
MMP11 / P24347 / matrix metallopeptidase 11ENSG0000009995329
MMP27 / Q9H306 / matrix metallopeptidase 27ENSG0000013767529
MMP7 / P09237 / matrix metallopeptidase 7ENSG0000013767319


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR021805  Peptidase M10A, matrix metallopeptidase, C-terminal
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028693  Matrix metalloproteinase-14
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001541 ovarian follicle development IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001935 endothelial cell proliferation IEA
 biological_processGO:0001958 endochondral ossification IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0008584 male gonad development IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0010831 positive regulation of myotube differentiation IEA
 biological_processGO:0010952 positive regulation of peptidase activity IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016477 cell migration IEA
 biological_processGO:0016485 protein processing TAS
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030307 positive regulation of cell growth IEA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030574 collagen catabolic process IEA
 biological_processGO:0031638 zymogen activation IEA
 biological_processGO:0035987 endodermal cell differentiation IEP
 biological_processGO:0035988 chondrocyte proliferation IEA
 biological_processGO:0043615 astrocyte cell migration IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0045579 positive regulation of B cell differentiation IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IEA
 biological_processGO:0048701 embryonic cranial skeleton morphogenesis IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0048771 tissue remodeling IEA
 biological_processGO:0048870 cell motility TAS
 biological_processGO:0051895 negative regulation of focal adhesion assembly IEA
 biological_processGO:0060322 head development IEA
 biological_processGO:0060348 bone development IEA
 biological_processGO:0097094 craniofacial suture morphogenesis IEA
 biological_processGO:1905523 positive regulation of macrophage migration IEA
 biological_processGO:1990834 response to odorant IEA
 cellular_componentGO:0005615 extracellular space IMP
 cellular_componentGO:0005634 nucleus IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0044354 macropinosome IDA
 cellular_componentGO:0045111 intermediate filament cytoskeleton IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016504 peptidase activator activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity TAS


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000212 Gingival hyperplasia 
Show

 HP:0000280 Coarse facial features 
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 HP:0003040 Arthropathy 
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 HP:0007957 Variable degree of corneal opacities 
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 HP:0009134 Osteolysis involving bones of the feet 
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 HP:0040160 Generalized osteoporosis 
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 HP:0045039 Osteolysis involving bones of the upper limbs 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000087245 MMP2 / P08253 / matrix metallopeptidase 2  / complex / reaction
 ENSG00000035862 TIMP2 / P16035 / TIMP metallopeptidase inhibitor 2  / reaction / complex
 ENSG00000140564 FURIN / P09958 / furin, paired basic amino acid cleaving enzyme  / reaction
 ENSG00000157227 MMP14 / P50281 / matrix metallopeptidase 14  / reaction
 ENSG00000091136 LAMB1 / P07942 / laminin subunit beta 1  / reaction
 ENSG00000142798 HSPG2 / P98160 / heparan sulfate proteoglycan 2  / reaction
 ENSG00000058085 LAMC2 / Q13753 / laminin subunit gamma 2  / reaction
 ENSG00000135862 LAMC1 / P11047 / laminin subunit gamma 1  / reaction
 ENSG00000116962 NID1 / P14543 / nidogen 1  / reaction
 ENSG00000130702 LAMA5 / O15230 / laminin subunit alpha 5  / reaction
 ENSG00000011465 DCN / P07585 / decorin  / reaction
 ENSG00000196878 LAMB3 / Q13751 / laminin subunit beta 3  / reaction
 ENSG00000053747 LAMA3 / Q16787 / laminin subunit alpha 3  / reaction
 ENSG00000137745 MMP13 / P45452 / matrix metallopeptidase 13  / reaction






 

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