ENSG00000125966


Homo sapiens

Features
Gene ID: ENSG00000125966
  
Biological name :MMP24
  
Synonyms : matrix metallopeptidase 24 / MMP24 / Q9Y5R2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q11.22
Gene start: 35226654
Gene end: 35277000
  
Corresponding Affymetrix probe sets: 208387_s_at (Human Genome U133 Plus 2.0 Array)   213171_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000246186
NCBI entrez gene - 10893     See in Manteia.
OMIM - 604871
RefSeq - XM_017027598
RefSeq - NM_006690
RefSeq - XM_011528500
RefSeq - XM_017027597
RefSeq Peptide - NP_006681
swissprot - Q9Y5R2
Ensembl - ENSG00000125966
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp24ENSDARG00000018896Danio rerio
 MMP24ENSGALG00000041093Gallus gallus
 Mmp24ENSMUSG00000027612Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MMP16 / P51512 / matrix metallopeptidase 16ENSG0000015610362
MMP15 / P51511 / matrix metallopeptidase 15ENSG0000010299652
MMP14 / P50281 / matrix metallopeptidase 14ENSG0000015722749
MMP25 / Q9NPA2 / matrix metallopeptidase 25ENSG0000000851630
MMP17 / Q9ULZ9 / matrix metallopeptidase 17ENSG0000019859830
MMP3 / P08254 / matrix metallopeptidase 3ENSG0000014996829
MMP1 / P03956 / matrix metallopeptidase 1ENSG0000019661129
MMP20 / O60882 / matrix metallopeptidase 20ENSG0000013767428
MMP10 / P09238 / matrix metallopeptidase 10ENSG0000016667028
MMP8 / P22894 / matrix metallopeptidase 8ENSG0000011811328
MMP13 / P45452 / matrix metallopeptidase 13ENSG0000013774528
MMP11 / P24347 / matrix metallopeptidase 11ENSG0000009995327
MMP12 / P39900 / matrix metallopeptidase 12ENSG0000026240627
MMP27 / Q9H306 / matrix metallopeptidase 27ENSG0000013767527
MMP7 / P09237 / matrix metallopeptidase 7ENSG0000013767317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021190  Peptidase M10A
 IPR021805  Peptidase M10A, matrix metallopeptidase, C-terminal
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028723  Matrix metalloproteinase-24
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010001 glial cell differentiation IEA
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0044331 cell-cell adhesion mediated by cadherin IEA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IEA
 biological_processGO:0097150 neuronal stem cell population maintenance IEA
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0032588 trans-Golgi network membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004222 metalloendopeptidase activity TAS
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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