ENSMUSG00000027612


Mus musculus

Features
Gene ID: ENSMUSG00000027612
  
Biological name :Mmp24
  
Synonyms : Matrix metalloproteinase-24 Processed matrix metalloproteinase-24 / Mmp24 / Q9R0S2
  
Possible biological names infered from orthology : matrix metallopeptidase 24 / Q9Y5R2
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H1
Gene start: 155775342
Gene end: 155818366
  
Corresponding Affymetrix probe sets: 10477725 (MoGene1.0st)   1417678_at (Mouse Genome 430 2.0 Array)   1441456_at (Mouse Genome 430 2.0 Array)   1442921_at (Mouse Genome 430 2.0 Array)   1448806_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029141
NCBI entrez gene - 17391     See in Manteia.
MGI - MGI:1341867
RefSeq - NM_010808
RefSeq Peptide - NP_034938
swissprot - Q9R0S2
Ensembl - ENSMUSG00000027612
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp24ENSDARG00000018896Danio rerio
 MMP24ENSGALG00000041093Gallus gallus
 MMP24ENSG00000125966Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp16 / Q9WTR0 / Matrix metalloproteinase-16 / P51512* / matrix metallopeptidase 16*ENSMUSG0000002822664
Mmp15 / O54732 / Matrix metalloproteinase-15 / P51511* / matrix metallopeptidase 15*ENSMUSG0000003179053
Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*ENSMUSG0000000095751
Mmp25 / Q3U435 / Matrix metalloproteinase-25 / Q9NPA2* / matrix metallopeptidase 25*ENSMUSG0000002390333
Mmp17 / Q9R0S3 / Matrix metalloproteinase-17 / Q9ULZ9* / matrix metallopeptidase 17*ENSMUSG0000002943631
Mmp3 / matrix metallopeptidase 3ENSMUSG0000004361329
Mmp10 / O55123 / matrix metallopeptidase 10 / P09238*ENSMUSG0000004756229
Mmp8 / O70138 / Neutrophil collagenase / P22894* / matrix metallopeptidase 8*ENSMUSG0000000580029
Mmp11 / Q02853 / Stromelysin-3 / P24347* / matrix metallopeptidase 11*ENSMUSG0000000090128
Mmp13 / P33435 / Collagenase 3 / P45452* / matrix metallopeptidase 13*ENSMUSG0000005057828
Mmp1a / interstitial collagenase A preproprotein / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004308928
Mmp27 / matrix metallopeptidase 27 / Q9H306*ENSMUSG0000007032328
Mmp20 / P57748 / Matrix metalloproteinase-20 / O60882* / matrix metallopeptidase 20*ENSMUSG0000001862028
Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004162028
Mmp12 / P34960 / Macrophage metalloelastase / P39900* / matrix metallopeptidase 12*ENSMUSG0000004972326
Mmp7 / matrix metallopeptidase 7 / P09237*ENSMUSG0000001862316


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021190  Peptidase M10A
 IPR021805  Peptidase M10A, matrix metallopeptidase, C-terminal
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028723  Matrix metalloproteinase-24
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010001 glial cell differentiation IDA
 biological_processGO:0044331 cell-cell adhesion mediated by cadherin IDA
 biological_processGO:0050965 detection of temperature stimulus involved in sensory perception of pain IMP
 biological_processGO:0097150 neuronal stem cell population maintenance IDA
 biological_processGO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0032588 trans-Golgi network membrane IDA
 molecular_functionGO:0004222 metalloendopeptidase activity IDA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0045296 cadherin binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Activation of Matrix Metalloproteinases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
Show

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001961 abnormal reflex "anomalies in an involuntary response to a peripheral stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
Show

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0002734 abnormal mechanical nociception "abnormal capability to sense pain elicited by mechanical stimulation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0003998 decreased thermal nociceptive threshold "a lower than average point at which thermal pain sensation is first detectable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0008763 abnormal mast cell degranulation "abnormalities in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

 MP:0008764 increased mast cell degranulation "increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdsntm1.1Ics/Cdsntm1.1Ics,Tg(KRT14-cre/ERT2)1Ipc/0
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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