ENSMUSG00000050578


Mus musculus

Features
Gene ID: ENSMUSG00000050578
  
Biological name :Mmp13
  
Synonyms : Collagenase 3 / Mmp13 / P33435
  
Possible biological names infered from orthology : matrix metallopeptidase 13 / P45452
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: A1
Gene start: 7272514
Gene end: 7283331
  
Corresponding Affymetrix probe sets: 10583044 (MoGene1.0st)   1417256_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000015394
NCBI entrez gene - 17386     See in Manteia.
MGI - MGI:1340026
RefSeq - NM_008607
RefSeq Peptide - NP_032633
swissprot - P33435
swissprot - Q3U9V5
Ensembl - ENSMUSG00000050578
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mmp13bENSDARG00000100794Danio rerio
 MMP13ENSGALG00000017183Gallus gallus
 MMP13ENSG00000137745Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mmp3 / matrix metallopeptidase 3ENSMUSG0000004361348
Mmp8 / O70138 / Neutrophil collagenase / P22894* / matrix metallopeptidase 8*ENSMUSG0000000580048
Mmp10 / O55123 / matrix metallopeptidase 10 / P09238*ENSMUSG0000004756248
Mmp27 / matrix metallopeptidase 27 / Q9H306*ENSMUSG0000007032347
Mmp20 / P57748 / Matrix metalloproteinase-20 / O60882* / matrix metallopeptidase 20*ENSMUSG0000001862046
Mmp1a / interstitial collagenase A preproprotein / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004308944
Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*ENSMUSG0000004162042
Mmp12 / P34960 / Macrophage metalloelastase / P39900* / matrix metallopeptidase 12*ENSMUSG0000004972342
Mmp24 / Q9R0S2 / Matrix metalloproteinase-24 Processed matrix metalloproteinase-24 / Q9Y5R2* / matrix metallopeptidase 24*ENSMUSG0000002761237
Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*ENSMUSG0000000095737
Mmp15 / O54732 / Matrix metalloproteinase-15 / P51511* / matrix metallopeptidase 15*ENSMUSG0000003179037
Mmp16 / Q9WTR0 / Matrix metalloproteinase-16 / P51512* / matrix metallopeptidase 16*ENSMUSG0000002822636
Mmp17 / Q9R0S3 / Matrix metalloproteinase-17 / Q9ULZ9* / matrix metallopeptidase 17*ENSMUSG0000002943634
Mmp25 / Q3U435 / Matrix metalloproteinase-25 / Q9NPA2* / matrix metallopeptidase 25*ENSMUSG0000002390333
Mmp11 / Q02853 / Stromelysin-3 / P24347* / matrix metallopeptidase 11*ENSMUSG0000000090131
Mmp7 / matrix metallopeptidase 7 / P09237*ENSMUSG0000001862326


Protein motifs (from Interpro)
Interpro ID Name
 IPR000585  Hemopexin-like domain
 IPR001818  Peptidase M10, metallopeptidase
 IPR002477  Peptidoglycan binding-like
 IPR006026  Peptidase, metallopeptidase
 IPR018486  Hemopexin, conserved site
 IPR018487  Hemopexin-like repeats
 IPR021158  Peptidase M10A, cysteine switch, zinc binding site
 IPR021190  Peptidase M10A
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR028711  Collagenase 3
 IPR033739  Peptidase M10A, catalytic domain
 IPR036365  PGBD-like superfamily
 IPR036375  Hemopexin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001958 endochondral ossification IMP
 biological_processGO:0003417 growth plate cartilage development IGI
 biological_processGO:0006508 proteolysis IMP
 biological_processGO:0022617 extracellular matrix disassembly IMP
 biological_processGO:0030282 bone mineralization IMP
 biological_processGO:0030574 collagen catabolic process ISO
 biological_processGO:0044267 cellular protein metabolic process IDA
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060349 bone morphogenesis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0031012 extracellular matrix IEA
 molecular_functionGO:0004222 metalloendopeptidase activity ISO
 molecular_functionGO:0004252 serine-type endopeptidase activity TAS
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005518 collagen binding IEA
 molecular_functionGO:0008233 peptidase activity IDA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000060 delayed bone ossification "late onset of the formation of bone" [J:40203]
Show

Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0000065 abnormal bone marrow cavities "absence or abnormal size or shape of the medullary cavities of the bones" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
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Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apctm2.1Cip/Apctm2.1Cip
Genetic Background: involves: 129P2/OlaHsd * C57BL/6N

Allelic Composition: Mmp13tm1Werb/Mmp13tm1Werb,Tg(Col2a1-cre)1Rsjo/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: TTg(MT2A-Myc)137Misu/TTg(MT2A-Myc)137Misu
Genetic Background: C57BL/6-TTg(MT2A-Myc)137Misu

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb
Genetic Background: involves: 129S2/SvPas

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
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Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Rag2tm1Fwa/Rag2tm1Fwa
Genetic Background: involves: 129S/SvEv * 129S6/SvEvTac * C57BL/6 * FVB/N

Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0002999 abnormal bone healing "defects in the restoration of integrity to bone after trauma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
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Allelic Composition: TTg(MT2A-Myc)137Misu/TTg(MT2A-Myc)137Misu
Genetic Background: C57BL/6-TTg(MT2A-Myc)137Misu

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mmp13tm1Werb/Mmp13tm1Werb,Tg(Col2a1-cre)1Rsjo/0
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: TTg(MT2A-Myc)137Misu/TTg(MT2A-Myc)137Misu
Genetic Background: C57BL/6-TTg(MT2A-Myc)137Misu

Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar
Genetic Background: B6.129S-Mmp13tm1Jdar

Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0006395 abnormal epiphyseal plate morphology "any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development" [MESH:A02.835.232.251.352]
Show

Allelic Composition: Mmp13tm1Jdar/Mmp13tm1Jdar,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0006398 increased long bone epiphyseal plate size "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

 MP:0006399 abnormal long bone epiphyseal ossification zone morphology "any anomaly in the structure of the layer of the epiphyseal plate where new bone matrix is deposited" [CALnet tutorial:http://137.222.110.150/calnet/Introanat/Introanat.htm, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mmp13tm1.1Werb/Mmp13tm1.1Werb,Mmp9tm1Tvu/Mmp9tm1Tvu
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac

 MP:0010872 increased trabecular bone mass "greater total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Top2btm2.1Jcw/Top2btm2.1Jcw
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028111 Ctsk / P55097 / cathepsin K / P43235*  / reaction
 ENSMUSG00000059481 Plg / P20918 / Plasminogen Plasmin heavy chain A Activation peptide Angiostatin Plasmin heavy chain A, short form Plasmin light chain B / LPA* / P00747* / P08519* / plasminogen* / lipoprotein(a)*  / reaction
 ENSMUSG00000030111 A2m / Q6GQT1 / alpha-2-macroglobulin / P01023*  / complex / reaction
 ENSMUSG00000027204 Fbn1 / Q61554 / Fibrillin-1 Asprosin / P35555* / fibrillin 1*  / reaction
 ENSMUSG00000010311 Optc / opticin isoform 4 / Q9UBM4* / opticin*  / reaction
 ENSMUSG00000024598 Fbn2 / Q61555 / Fibrillin-2 Fibrillin-2 C-terminal peptide / P35556* / fibrillin 2*  / reaction
 ENSMUSG00000021477 Ctsl / P06797 / cathepsin L / CTSV* / O60911* / cathepsin V*  / reaction
 ENSMUSG00000000957 Mmp14 / P53690 / Matrix metalloproteinase-14 / P50281* / matrix metallopeptidase 14*  / reaction






 

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