ENSMUSG00000030111


Mus musculus

Features
Gene ID: ENSMUSG00000030111
  
Biological name :A2m
  
Synonyms : A2m / alpha-2-macroglobulin / Q6GQT1
  
Possible biological names infered from orthology : P01023
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: F1
Gene start: 121635376
Gene end: 121679227
  
Corresponding Affymetrix probe sets: 10541354 (MoGene1.0st)   1434719_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144862
Ensembl peptide - ENSMUSP00000032203
NCBI entrez gene - 232345     See in Manteia.
MGI - MGI:2449119
RefSeq - NM_175628
RefSeq Peptide - NP_783327
swissprot - A0A0N4SUX6
swissprot - Q6GQT1
Ensembl - ENSMUSG00000030111
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000031659Gallus gallus
 ENSGALG00000039764Gallus gallus
 A2MENSG00000175899Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mug1 / P28665 / Murinoglobulin-1 ENSMUSG0000005990857
Pzp / Q61838 / Pregnancy zone protein Alpha-2-macroglobulin 165 kDa subunit Alpha-2-macroglobulin 35 kDa subunitENSMUSG0000003035956
Mug2 / P28666 / Murinoglobulin-2 ENSMUSG0000003013156
Gm7298ENSMUSG0000010802256
A2ml1 / Q3UU35 / alpha-2-macroglobulin like 1ENSMUSG0000004722838
Cd109 / Q8R422 / CD109 antigen / Q6YHK3* / CD109 molecule*ENSMUSG0000004618625
C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...ENSMUSG0000002416423
C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...ENSMUSG0000007341822
Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*ENSMUSG0000002687421


Protein motifs (from Interpro)
Interpro ID Name
 IPR001599  Alpha-2-macroglobulin
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR019565  Alpha-2-macroglobulin, thiol-ester bond-forming
 IPR019742  Alpha-2-macroglobulin, conserved site
 IPR036595  Alpha-macroglobulin, receptor-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001869 negative regulation of complement activation, lectin pathway IEA
 biological_processGO:0007565 female pregnancy IEA
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0048863 stem cell differentiation IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity ISO
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0019959 interleukin-8 binding IEA
 molecular_functionGO:0019966 interleukin-1 binding IEA
 molecular_functionGO:0030414 peptidase inhibitor activity TAS
 molecular_functionGO:0043120 tumor necrosis factor binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Degradation of the extracellular matrix
Rho GTPase cycle
HDL assembly


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000050578 Mmp13 / P33435 / Collagenase 3 / P45452* / matrix metallopeptidase 13*  / complex / reaction
 ENSMUSG00000109764 Klkb1 / P26262 / Plasma kallikrein Plasma kallikrein heavy chain Plasma kallikrein light chain / P03952* / kallikrein B1*  / reaction / complex
 ENSMUSG00000030111 A2m / Q6GQT1 / alpha-2-macroglobulin / P01023*  / complex
 ENSMUSG00000041620 Mmp1b / MMP1* / P03956* / matrix metallopeptidase 1*  / reaction / complex






 

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