ENSMUSG00000030359


Mus musculus

Features
Gene ID: ENSMUSG00000030359
  
Biological name :Pzp
  
Synonyms : Pregnancy zone protein Alpha-2-macroglobulin 165 kDa subunit Alpha-2-macroglobulin 35 kDa subunit / Pzp / Q61838
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: F3
Gene start: 128483567
Gene end: 128526720
  
Corresponding Affymetrix probe sets: 10548207 (MoGene1.0st)   1417246_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120114
Ensembl peptide - ENSMUSP00000107760
NCBI entrez gene - 11287     See in Manteia.
MGI - MGI:87854
RefSeq - NM_007376
RefSeq Peptide - NP_031402
swissprot - D3YUI3
swissprot - Q61838
Ensembl - ENSMUSG00000030359
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000031659Gallus gallus
 ENSGALG00000039764Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
A2m / Q6GQT1 / alpha-2-macroglobulin / P01023*ENSMUSG0000003011155
Mug1 / P28665 / Murinoglobulin-1 ENSMUSG0000005990850
Gm7298ENSMUSG0000010802250
Mug2 / P28666 / Murinoglobulin-2 ENSMUSG0000003013148
A2ml1 / Q3UU35 / alpha-2-macroglobulin like 1ENSMUSG0000004722836
Cd109 / Q8R422 / CD109 antigen / Q6YHK3* / CD109 molecule*ENSMUSG0000004618625
C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...ENSMUSG0000007341822
C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...ENSMUSG0000002416422
Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*ENSMUSG0000002687420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001599  Alpha-2-macroglobulin
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR019565  Alpha-2-macroglobulin, thiol-ester bond-forming
 IPR019742  Alpha-2-macroglobulin, conserved site
 IPR036595  Alpha-macroglobulin, receptor-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007566 embryo implantation IGI
 biological_processGO:0010466 negative regulation of peptidase activity IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA
 molecular_functionGO:0004867 serine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0030414 peptidase inhibitor activity IEA
 molecular_functionGO:0048403 brain-derived neurotrophic factor binding IEA
 molecular_functionGO:0048406 nerve growth factor binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000062 increased bone density "increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]
Show

Allelic Composition: Pzptm1Lex/Pzptm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0000341 abnormal bile color "a change in the color of the bile from the normal yellowish brown or green " [J:80519]
Show

Allelic Composition: Agtpbp1pcd-5J/Agtpbp1pcd-5J
Genetic Background: DBA/2J

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Agtpbp1pcd-5J/Agtpbp1pcd-5J
Genetic Background: DBA/2J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Agtpbp1pcd-5J/Agtpbp1pcd-5J
Genetic Background: DBA/2J

Allelic Composition: Pzptm1Lex/Pzptm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0001511 disheveled coat "coat that looks generally unkempt" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Agtpbp1pcd-5J/Agtpbp1pcd-5J
Genetic Background: DBA/2J

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pzptm1Vln/Pzptm1Vln
Genetic Background: B.129P2-Pzptm1Vln

 MP:0001657 abnormal induced morbidity/mortality "differences from the expected diseased state or death caused by an external intervention" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pzptm1Vln/Pzptm1Vln
Genetic Background: B.129P2-Pzptm1Vln

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pzptm1Vln/Pzptm1Vln
Genetic Background: B.129P2-Pzptm1Vln

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Agtpbp1pcd-5J/Agtpbp1pcd-5J
Genetic Background: DBA/2J

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtpbp1pcd-5J/Agtpbp1pcd-5J
Genetic Background: DBA/2J

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtpbp1pcd-5J/Agtpbp1pcd-5J
Genetic Background: DBA/2J

 MP:0002830 gallstones "caliculi in the gallbladder or a bile duct; chemical composition of cholesterol, calcium carbonate or calcium bilirubinate" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Agtpbp1pcd-5J/Agtpbp1pcd-5J
Genetic Background: DBA/2J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pgrtm3(rtTA2S*M2)Lyd/Pgrtm3(rtTA2S*M2)Lyd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003829 impaired febrile response "reduced or absent febrile response to exogenous or endogenous pyrogens" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:70534]
Show

Allelic Composition: Pgrtm3(rtTA2S*M2)Lyd/Pgrtm3(rtTA2S*M2)Lyd
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003845 abnormal decidualization "disrupted proliferation, differentiation or transformation of endometrial stromal cells into decidual cells in the maternal uterus following embryo implantation" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:43609, J:48920]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0003849 greasy coat "fur is oily in appearance or texture" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agtpbp1pcd-5J/Agtpbp1pcd-5J
Genetic Background: DBA/2J

 MP:0004014 abnormal uterine environment "anomaly or inability of the uterus to support embryonic development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004256 abnormal maternal decidual layer morphology "anomaly in the structure of the maternal uterine-derived portion of the placenta" [PMID:11433360]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004761 susceptibility to induced pancreatitis "more likely than normal to develop an inflammatory response, or an increased inflammatory response in the pancreatic tissue after experimental manipulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtpbp1pcd-5J/Agtpbp1pcd-5J
Genetic Background: DBA/2J

 MP:0005031 abnormal trophoblast "malformation of the mesectodermal cell layer covering the blastocyst that erodes the uterine mucosa and contributes to the formation of the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Pzptm1Lex/Pzptm1Lex
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Pzptm1Vln/Pzptm1Vln
Genetic Background: B.129P2-Pzptm1Vln

 MP:0008054 abnormal uterine NK cell morphology "any structural anomaly of the uterine subset of the non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pzptm1Vln/Pzptm1Vln
Genetic Background: B.129P2-Pzptm1Vln

 MP:0008806 increased circulating amylase level "greater concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pzptm1Vln/Pzptm1Vln
Genetic Background: B.129P2-Pzptm1Vln

 MP:0009145 abnormal pancreatic acinus morphology "any structural anomaly of the secretory units of the exocrine pancreas, where fluid containing digestive enzymes is produced; consists of a group of secretory cells surrounding a luminal space that connects to the pancreatic duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Pzptm1Vln/Pzptm1Vln
Genetic Background: B.129P2-Pzptm1Vln

 MP:0009146 abnormal pancreatic acinar cell morphology "any structural anomaly of the secretory cells of the exocrine pancreas that produce fluid containing digestive enzymes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pzptm1Vln/Pzptm1Vln
Genetic Background: B.129P2-Pzptm1Vln

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pzptm1Vln/Pzptm1Vln
Genetic Background: B.129P2-Pzptm1Vln

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtpbp1pcd-5J/Agtpbp1pcd-5J
Genetic Background: DBA/2J

 MP:0010182 decreased susceptibility to weight gain "smaller increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agtpbp1pcd-5J/Agtpbp1pcd-5J
Genetic Background: DBA/2J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011886 increased circulating lipase level "elevated blood level of lipase in the blood, in particular the serum" [MGI:csmith]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pzptm1Vln/Pzptm1Vln
Genetic Background: B.129P2-Pzptm1Vln

 MP:0012726 abnormal uterine spiral artery morphology "any structural anomaly of the corkscrew-like arteries in premenstrual or progestational endometrium; uterine spiral arteries play a vital role in supplying nutrients to the placenta and fetus, and are thus remodeled into highly dilated inelastic vessels by the action of invading trophoblast (physiological change)" [MGI:anna]
Show

Allelic Composition: Ptges3Gt(W069F07)Wrst/Ptges3Gt(W069F07)Wrst
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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