ENSMUSG00000026874


Mus musculus

Features
Gene ID: ENSMUSG00000026874
  
Biological name :Hc
  
Synonyms : Hc / hemolytic complement / P06684
  
Possible biological names infered from orthology : C5 / complement C5 / P01031
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: B
Gene start: 34983331
Gene end: 35061438
  
Corresponding Affymetrix probe sets: 10481962 (MoGene1.0st)   1419407_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144345
Ensembl peptide - ENSMUSP00000028233
NCBI entrez gene - 15139     See in Manteia.
MGI - MGI:96031
RefSeq - NM_010406
RefSeq - XM_017315669
RefSeq Peptide - NP_034536
swissprot - A0A0J9YUU3
swissprot - P06684
Ensembl - ENSMUSG00000026874
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c5ENSDARG00000021004Danio rerio
 C5ENSGALG00000001565Gallus gallus
 C5ENSG00000106804Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...ENSMUSG0000002416427
C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...ENSMUSG0000007341825
A2m / Q6GQT1 / alpha-2-macroglobulin / P01023*ENSMUSG0000003011118
Pzp / Q61838 / Pregnancy zone protein Alpha-2-macroglobulin 165 kDa subunit Alpha-2-macroglobulin 35 kDa subunitENSMUSG0000003035918
A2ml1 / Q3UU35 / alpha-2-macroglobulin like 1ENSMUSG0000004722818
Gm7298ENSMUSG0000010802218
Mug1 / P28665 / Murinoglobulin-1 ENSMUSG0000005990818
Mug2 / P28666 / Murinoglobulin-2 ENSMUSG0000003013118
Cd109 / Q8R422 / CD109 antigen / Q6YHK3* / CD109 molecule*ENSMUSG0000004618617


Protein motifs (from Interpro)
Interpro ID Name
 IPR000020  Anaphylatoxin/fibulin
 IPR001134  Netrin domain
 IPR001599  Alpha-2-macroglobulin
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR013783  Immunoglobulin-like fold
 IPR018081  Anaphylatoxin, complement system
 IPR018933  Netrin module, non-TIMP type
 IPR036595  Alpha-macroglobulin, receptor-binding domain superfamily
 IPR037562  Complement C5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IGI
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006957 complement activation, alternative pathway IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010760 negative regulation of macrophage chemotaxis IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0019835 cytolysis IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0090197 positive regulation of chemokine secretion IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005579 membrane attack complex IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Terminal pathway of complement
Activation of C3 and C5
Peptide ligand-binding receptors
G alpha (i) signalling events
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000947 convulsive seizures "seizures characterized by uncontrolled motor activity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0001257 increased body length "increased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mapk7tm1Jsca/Mapk7tm1Jsca
Genetic Background: either: (involves: BALB/c) or (involves: C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Xisttm2Nbd/Xist+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tmc1Mhdabth/Tmc1+,Tmc1m4DBA/2J/?
Genetic Background: involves: C3HeB/FeJ * DBA/2J

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Ptentm2Mak/Ptentm2Mak,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * DBA

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Disc1del/Disc1del
Genetic Background: B6.129S6-Disc1del

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Il10tm1Roer/Il10tm1Roer,Foxp3tm4(YFP/icre)Ayr/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Disc1del/Disc1del
Genetic Background: B6.129S6-Disc1del

Allelic Composition: Hc0/Hc0
Genetic Background: B10.D2-Hc0 H2d H2-T18c/oSnJ

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
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Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001128 Cfp / P11680 / complement factor properdin / P27918*  / reaction
 ENSMUSG00000015083 C8g / Q8VCG4 / Complement component C8 gamma chain / P07360* / complement C8 gamma chain*  / complex / reaction
 ENSMUSG00000017344 Vtn / P29788 / vitronectin / P04004*  / complex / reaction
 ENSMUSG00000068686 Cd59b / P58019 / CD59B glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / complex / reaction
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / complex
 ENSMUSG00000079105 C7 / complement component 7 / P10643* / complement C7*  / reaction / complex
 ENSMUSG00000032679 Cd59a / O55186 / CD59A glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / reaction / complex
 ENSMUSG00000022149 C9 / complement C9 / P02748*  / complex / reaction
 ENSMUSG00000022037 Clu / Q06890 / Clusterin Clusterin beta chain Clusterin alpha chain / P10909* / clusterin*  / reaction / complex
 ENSMUSG00000024371 C2 / P21180 / Complement C2 Complement C2b fragment Complement C2a fragment / P06681* / complement C2*  / reaction
 ENSMUSG00000090231 Cfb / P04186 / Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment / P00751* / AL645922.1* / complement factor B*  / reaction
 ENSMUSG00000025196 Cpn1 / Q9JJN5 / carboxypeptidase N, polypeptide 1 / P15169* / carboxypeptidase N subunit 1*  / reaction
 ENSMUSG00000021999 Cpb2 / Q9JHH6 / Carboxypeptidase B2 / Q96IY4*  / reaction
 ENSMUSG00000022181 C6 / complement component 6 / P13671* / complement C6*  / complex / reaction
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / reaction
 ENSMUSG00000029656 C8b / Q8BH35 / Complement component C8 beta chain / P07358* / complement C8 beta chain*  / complex / reaction
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000073418 C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...  / reaction
 ENSMUSG00000049130 C5ar1 / P30993 / C5a anaphylatoxin chemotactic receptor 1 / P21730* / complement C5a receptor 1*  / complex / reaction
 ENSMUSG00000035031 C8a / Q8K182 / Complement component C8 alpha chain / P07357* / complement C8 alpha chain*  / reaction / complex
 ENSMUSG00000023176 Cpn2 / Q9DBB9 / Carboxypeptidase N subunit 2 / P22792*  / reaction
 ENSMUSG00000074361 C5ar2 / complement component 5a receptor 2 / Q9P296*  / complex / reaction






 

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