ENSMUSG00000024164


Mus musculus

Features
Gene ID: ENSMUSG00000024164
  
Biological name :C3
  
Synonyms : C3 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain fragment 1 Complement C3dg fragment Complement C3g fragment Complement C3d fragment Complement C3f fragment Complement C3c alpha chain fragment 2 / P01027
  
Possible biological names infered from orthology : complement C3 / P01024
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: D
Gene start: 57203970
Gene end: 57228136
  
Corresponding Affymetrix probe sets: 10452316 (MoGene1.0st)   1423954_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135663
Ensembl peptide - ENSMUSP00000024988
Ensembl peptide - ENSMUSP00000135560
NCBI entrez gene - 12266     See in Manteia.
MGI - MGI:88227
RefSeq - NM_009778
RefSeq Peptide - NP_033908
swissprot - P01027
swissprot - H3BKW9
swissprot - H3BL60
Ensembl - ENSMUSG00000024164
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c3a.1ENSDARG00000012694Danio rerio
 c3a.2ENSDARG00000087359Danio rerio
 c3a.3ENSDARG00000052207Danio rerio
 c3a.4ENSDARG00000093198Danio rerio
 c3a.5ENSDARG00000053462Danio rerio
 c3a.6ENSDARG00000043719Danio rerio
 c3b.1ENSDARG00000093068Danio rerio
 c3b.2ENSDARG00000001818Danio rerio
 C3ENSG00000125730Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...ENSMUSG0000007341828
Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*ENSMUSG0000002687427
A2m / Q6GQT1 / alpha-2-macroglobulin / P01023*ENSMUSG0000003011121
Pzp / Q61838 / Pregnancy zone protein Alpha-2-macroglobulin 165 kDa subunit Alpha-2-macroglobulin 35 kDa subunitENSMUSG0000003035920
Gm7298ENSMUSG0000010802220
Cd109 / Q8R422 / CD109 antigen / Q6YHK3* / CD109 molecule*ENSMUSG0000004618620
Mug1 / P28665 / Murinoglobulin-1 ENSMUSG0000005990819
Mug2 / P28666 / Murinoglobulin-2 ENSMUSG0000003013119
A2ml1 / Q3UU35 / alpha-2-macroglobulin like 1ENSMUSG0000004722817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000020  Anaphylatoxin/fibulin
 IPR001134  Netrin domain
 IPR001599  Alpha-2-macroglobulin
 IPR001840  Anaphylatoxin, complement system domain
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR013783  Immunoglobulin-like fold
 IPR018081  Anaphylatoxin, complement system
 IPR018933  Netrin module, non-TIMP type
 IPR019565  Alpha-2-macroglobulin, thiol-ester bond-forming
 IPR019742  Alpha-2-macroglobulin, conserved site
 IPR035711  Complement C3-like
 IPR035815  Complement C3-like, NTR domain
 IPR036595  Alpha-macroglobulin, receptor-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001798 positive regulation of type IIa hypersensitivity IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0001970 positive regulation of activation of membrane attack complex IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006911 phagocytosis, engulfment IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006956 complement activation IEA
 biological_processGO:0006957 complement activation, alternative pathway IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0010575 positive regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010828 positive regulation of glucose transmembrane transport IEA
 biological_processGO:0010866 regulation of triglyceride biosynthetic process IEA
 biological_processGO:0010884 positive regulation of lipid storage IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0050766 positive regulation of phagocytosis IMP
 biological_processGO:0097242 amyloid-beta clearance IMP
 biological_processGO:2000427 positive regulation of apoptotic cell clearance IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 cellular_componentGO:0032991 protein-containing complex IDA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031715 C5L2 anaphylatoxin chemotactic receptor binding IEA


Pathways (from Reactome)
Pathway description
Alternative complement activation
Activation of C3 and C5
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (i) signalling events
Neutrophil degranulation
Post-translational protein phosphorylation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000336 decreased mast cell number "fewer than expected number of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000477 abnormal intestine morphology "malformation of the digestive tube passing from the stomach to the anus" [J:48968]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000685 abnormal immune system morphology "morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0000747 muscle weakness "loss of muscle strength" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Frem1bat/Frem1+
Genetic Background: C57BL/6J-Frem1bat

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: involves: 129/Sv

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001364 decreased anxiety-related response "when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:86626, J:85438, J:64043]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: involves: 129/Sv

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: involves: 129/Sv

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001657 abnormal induced morbidity/mortality "differences from the expected diseased state or death caused by an external intervention" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001661 extended life span "persistence of life for a longer period than is the norm for an organism" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgb1tm1Mll/Itgb1tm1Mll,Tg(Nes-cre)1Kln/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

 MP:0001729 impaired implantation "impaired ability of the blastocyst to attach to the endometrium of the uterus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dll1tm1Gos/Dll1tm1Gos
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hc0/Hc0
Genetic Background: B10.D2-Hc0 H2d H2-T18c/oSnJ

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: either: (involves: 129S2/SvPas * C57BL/6) or (involves: 129X1/SvJ * C57BL/6)

Allelic Composition: C3tm1Crr/C3tm1Crr
Genetic Background: B6;129S4-C3tm1Crr/J

 MP:0002421 abnormal cell-mediated immunity "abnormal function of any adaptive immune response in which T cells play a main role " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002471 abnormal complement cascade "impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002472 impaired complement alternative pathway "abnormal function of the plasma protein cascade triggered by direct contact with pathogen surfaces" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: involves: 129/Sv

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hc0/Hc0
Genetic Background: B10.D2-Hc0 H2d H2-T18c/oSnJ

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: involves: 129/Sv

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hc0/Hc0
Genetic Background: B10.D2-Hc0 H2d H2-T18c/oSnJ

 MP:0002919 enhanced paired-pulse facilitation "increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0003071 decreased vascular permeability "reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0003240 loss of hippocampal neurons "loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event" [RGD:Rat Genome Database submission]
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Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum
Genetic Background: C57BL/6-Zc3h12atm1Fum

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Zc3h12atm1Fum/Zc3h12atm1Fum
Genetic Background: C57BL/6-Zc3h12atm1Fum

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0003699 abnormal female reproductive system physiology "anomaly in the function of the female organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0003851 skeletal muscle interstitial fibrosis "formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

 MP:0004001 decreased hepatocyte proliferation "reduced growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan/J

 MP:0004220 abnormal peripheral nervous system regeneration "changes in the ability or inability of healthy peripheral nervous system tissue to regenerate following injury or disease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0004259 small placenta "reduced size of the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0004262 abnormal physical strength "altered ability of an organism to exert force on physical objects or of the body to support its load" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lama2dy/Lama2dy
Genetic Background: either: (involves: 129S2/SvPas * 129P1/ReJ) or (involves: 129X1/SvJ * 129P1/ReJ)

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0004792 abnormal synaptic vesicle number "anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan/J

Allelic Composition: C3tm1Crr/C3tm1Crr,Fcer1gtm1Rav/Fcer1gtm1Rav,Tg(Ins2-TFRC/OVA)296Wehi/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004828 decreased susceptibility to autoimmune hemolytic anemia "reduced likelihood that an organism will develop an abnormality of the immune system that destroys red blood cells (hemolysis) prematurely" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0004859 abnormal synaptic plasticity "anomaly in the ability of a synapse to change its strength as a result of successive activations" [MESH:National Library of Medicine_Medical Subject Headings, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: C3tm1Crr/C3tm1Crr
Genetic Background: involves: 129S4/SvJae

 MP:0005288 abnormal oxygen consumption "deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: involves: 129/Sv

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0005342 abnormal lipid absorption "anomalous ability of the body to take in fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: involves: 129/Sv

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan/J

Allelic Composition: C3tm1Crr/C3tm1Crr,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm C3tm1Crr

 MP:0005351 decreased susceptibility to autoimmune disorders "reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: C3tm1Crr/C3tm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0005450 abnormal energy expenditure "utilization of calories that differs from the norm " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Lepob/Lepob
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Npr2cn/Npr2slw
Genetic Background: involves: AKR/J * C57BL/6 * DDY

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Cd55tm1Song/Cd55tm1Song,Cr1ltm1Hmo/Cr1ltm1Hmo,Vsig4tm1Gne/Vsig4tm1Gne
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N

 MP:0005517 decreased liver regeneration "less than the normal ability of liver to regenerate healthy tissue following partial hepatectomy" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: B6.129-C3tm1Hrc

 MP:0005540 decreased albumin excretion "less than the normal amount of this protein voided by the kidneys" [RGD:Rat Genome Database submission]
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Allelic Composition: C3tm1Crr/C3tm1Crr
Genetic Background: involves: 129S4/SvJae

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: C3tm1Crr/C3tm1Crr
Genetic Background: B6;129S4-C3tm1Crr/J

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0005668 decreased circulating leptin level "less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: involves: 129/Sv

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0008267 abnormal hippocampus CA3 region morphology 
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0008428 abnormal spatial working memory "anomaly in the ability to spontaneously process spatial location information in order to naviagate or perform other behavior using such locational cues, without previous encounters or training at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0008542 enlarged cervical lymph nodes "increased size of the lymph nodes found near the neck and shoulders" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: C3tm1Crr/C3tm1Crr,C4btm1Crr/C4btm1Crr,Faslpr/Faslpr
Genetic Background: involves: 129S4/SvJae * C57BL/6 * MRL

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: 1700016L21RikTg(Itgax-DTR/EGFP)57Lan/0
Genetic Background: B6.FVB-1700016L21RikTg(Itgax-DTR/EGFP)57Lan/J

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0008947 increased neuron number "greater than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0009006 prolonged estrous cycle "increase in the length of the sexual cycle of female animals" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0009453 enhanced contextual conditioning "increase in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0009788 increased susceptibility to bacterial infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Oas1bFlv-mr/Oas1bFlv-mr
Genetic Background: MOLD/RkJ

 MP:0009936 abnormal dendritic spine morphology "any structural anomaly of the small membranous protrusion from the dendrite of a neuron that is involved in synaptic transmission; it typically receives input from a single synapse of an axon" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Oca2p-81H/Oca2p-81H
Genetic Background: Not Specified

Allelic Composition: C3tm1Hrc/C3tm1Hrc
Genetic Background: involves: 129/Sv

 MP:0011521 decreased placental labyrinth size "reduction in the size of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0012099 decreased spongiotrophoblast size "reduction of the size of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors" [MGI:csmith]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0012306 enhanced spatial learning "enhanced ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues" [MGI:csmith]
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Allelic Composition: Ighmbp2nmd-2J/Ighmbp2nmd-2J,Tg(Eno2-Ighmbp2)17Cx/?,Tg(Ttn-Ighmbp2)45Cx/?
Genetic Background: involves: C57BL/6J * C57BLKS/J

 MP:0020448 increased microglial cell activation "increase in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
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Allelic Composition: C3tm1Crr/C3tm1Crr,Zbtb20Tg(PDGFB-APPSwInd)20Lms/?
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024371 C2 / P21180 / Complement C2 Complement C2b fragment Complement C2a fragment / P06681* / complement C2*  / reaction / complex
 ENSMUSG00000026399 Cd55 / Q61475 / Complement decay-accelerating factor, GPI-anchored / P08174* / CD55 molecule (Cromer blood group)*  / reaction / complex
 ENSMUSG00000090231 Cfb / P04186 / Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment / P00751* / AL645922.1* / complement factor B*  / reaction / complex
 ENSMUSG00000025196 Cpn1 / Q9JJN5 / carboxypeptidase N, polypeptide 1 / P15169* / carboxypeptidase N subunit 1*  / reaction
 ENSMUSG00000021999 Cpb2 / Q9JHH6 / Carboxypeptidase B2 / Q96IY4*  / reaction
 ENSMUSG00000057037 Cfhr1 / complement factor H-related 1 / CFHR5* / CFHR2* / P36980* / Q9BXR6* / Q03591* / BX248415.1* / complement factor H related 5* / complement factor H related 2*  / reaction / complex
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / complex / reaction
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction
 ENSMUSG00000026401 Cd55b / CD55* / P08174* / CD55 molecule (Cromer blood group)*  / complex / reaction
 ENSMUSG00000058952 Cfi / Q61129 / Mus musculus complement component factor i (Cfi), transcript variant 2, mRNA. / P05156* / AC126283.2* / complement factor I*  / complex / reaction
 ENSMUSG00000001128 Cfp / P11680 / complement factor properdin / P27918*  / complex / reaction
 ENSMUSG00000040552 C3ar1 / O09047 / C3a anaphylatoxin chemotactic receptor / Q16581* / complement C3a receptor 1*  / complex / reaction
 ENSMUSG00000037706 Cd81 / P35762 / CD81 antigen / P60033* / CD81 molecule*  / reaction / complex
 ENSMUSG00000030724 Cd19 / P25918 / Mus musculus CD19 antigen (Cd19), transcript variant 2, mRNA. / P15391* / CD19 molecule*  / complex / reaction
 ENSMUSG00000073418 C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...  / complex / reaction
 ENSMUSG00000061780 Cfd / P03953 / Complement factor D / P00746*  / reaction
 ENSMUSG00000023176 Cpn2 / Q9DBB9 / Carboxypeptidase N subunit 2 / P22792*  / reaction
 ENSMUSG00000016493 Cd46 / O88174 / Membrane cofactor protein / P15529* / CD46 molecule*  / complex / reaction






 

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