ENSDARG00000012694


Danio rerio

Features
Gene ID: ENSDARG00000012694
  
Biological name :c3a.1
  
Synonyms : c3a.1 / complement component c3a, duplicate 1
  
Possible biological names infered from orthology : C3 / complement C3 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain fragment 1 Complement C3dg fragment Complement C3g fragment Complement C3d fragment Complement C3f fragment Complement C3c alpha chain fragment 2 / P01024 / P01027
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 56130222
Gene end: 56176976
  
Corresponding Affymetrix probe sets: Dr.6845.1.S1_at (Zebrafish Array)   Dr.7722.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000052687
NCBI entrez gene - 321046     See in Manteia.
RefSeq - NM_131242
RefSeq Peptide - NP_571317
swissprot - B8JKW4
ZFIN ID - ZDB-GENE-990415-35
Ensembl - ENSDARG00000012694
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 C3ENSG00000125730Homo sapiens
 C3ENSMUSG00000024164Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
c3a.2 / complement component c3a, duplicate 2 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acyla...ENSDARG0000008735970
c3a.3 / complement component c3a, duplicate 3 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acyla...ENSDARG0000005220769
c3a.6 / complement component c3a, duplicate 6 / C3* / P01024* / complement C3*ENSDARG0000004371962
c3a.4 / complement component c3a, duplicate 4 / C3* / P01024* / complement C3*ENSDARG0000009319855
c3b.2 / complement component c3b, tandem duplicate 2 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxi...ENSDARG0000000181835
c3b.1 / complement component c3b, tandem duplicate 1 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxi...ENSDARG0000009306835
c3a.5 / complement component c3a, duplicate 5 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acyla...ENSDARG0000005346233
c4 / complement component 4 / C4A* / C4B* / P0C0L5* / P01029* / P0C0L4* / complement C4B (Chido blood group)* / complement C4A (Rodgers blood group)* / Complement C4-B Complement C4 beta ch...ENSDARG0000001506529
si:dkey-8k3.2ENSDARG0000003842426
c5 / complement component 5 / P01031* / complement C5*ENSDARG0000002100425
cpamd8 / C3 and PZP-like, alpha-2-macroglobulin domain containing 8 / Q8IZJ3*ENSDARG0000005653019
a2ml / alpha-2-macroglobulin-like / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000005631419
sb:cb37 / si:dkey-105h12.2 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000004164519
si:dkey-46g23.5 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000000883518
si:dkey-105h12.2 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000004168518
si:ch211-212c13.10 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000009319918
si:dkey-46g23.2 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011581718
zgc:165453 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007818317
zgc:165518 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007573717
zgc:171446 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011600517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000020  Anaphylatoxin/fibulin
 IPR001134  Netrin domain
 IPR001599  Alpha-2-macroglobulin
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR013783  Immunoglobulin-like fold
 IPR018081  Anaphylatoxin, complement system
 IPR018933  Netrin module, non-TIMP type
 IPR019565  Alpha-2-macroglobulin, thiol-ester bond-forming
 IPR019742  Alpha-2-macroglobulin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006956 complement activation IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0043009 chordate embryonic development IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Alternative complement activation
Activation of C3 and C5
Peptide ligand-binding receptors
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
G alpha (i) signalling events
Neutrophil degranulation
Post-translational protein phosphorylation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism malformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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