ENSDARG00000056314


Danio rerio

Features
Gene ID: ENSDARG00000056314
  
Biological name :a2ml
  
Synonyms : a2ml / alpha-2-macroglobulin-like
  
Possible biological names infered from orthology : A2ML1 / A8K2U0 / alpha-2-macroglobulin like 1
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 21113965
Gene end: 21132480
  
Corresponding Affymetrix probe sets: Dr.25331.1.S1_at (Zebrafish Array)   Dr.25379.1.S1_at (Zebrafish Array)   Dr.3025.2.S1_at (Zebrafish Array)   Dr.3025.3.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000073195
Ensembl peptide - ENSDARP00000132820
NCBI entrez gene - 100006972     See in Manteia.
RefSeq - XM_021481320
RefSeq - NM_001139479
RefSeq Peptide - NP_001132951
swissprot - F6NTZ9
swissprot - A0A0R4IDD1
ZFIN ID - ZDB-GENE-090212-1
Ensembl - ENSDARG00000056314
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000000293Gallus gallus
 ENSGALG00000014252Gallus gallus
 A2ML1ENSGALG00000036447Gallus gallus
 A2ML1ENSG00000166535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sb:cb37 / si:dkey-105h12.2 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000004164597
si:dkey-105h12.2 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000004168587
si:ch211-212c13.10 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000009319976
A2ML1 (1 of many) / si:ch211-212c13.8 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007875769
si:dkey-46g23.5 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000000883558
zgc:165518 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007573758
si:dkey-46g23.2 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011581757
zgc:165453 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007818357
zgc:171446 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011600557
zgc:171445 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011520557
zgc:171426 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007476433
cpamd8 / C3 and PZP-like, alpha-2-macroglobulin domain containing 8 / Q8IZJ3*ENSDARG0000005653025
cd109 / CD109 molecule / Q6YHK3* / Q8R422* / CD109 antigen *ENSDARG0000006060923
c3a.1 / complement component c3a, duplicate 1 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acyla...ENSDARG0000001269421
c4 / complement component 4 / C4A* / C4B* / P0C0L5* / P01029* / P0C0L4* / complement C4B (Chido blood group)* / complement C4A (Rodgers blood group)* / Complement C4-B Complement C4 beta ch...ENSDARG0000001506521
c3a.4 / complement component c3a, duplicate 4 / C3* / P01024* / complement C3*ENSDARG0000009319821
c3b.1 / complement component c3b, tandem duplicate 1 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxi...ENSDARG0000009306820
si:dkey-8k3.2ENSDARG0000003842420
c3b.2 / complement component c3b, tandem duplicate 2 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxi...ENSDARG0000000181820
c3a.2 / complement component c3a, duplicate 2 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acyla...ENSDARG0000008735920


Protein motifs (from Interpro)
Interpro ID Name
 IPR001599  Alpha-2-macroglobulin
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR019565  Alpha-2-macroglobulin, thiol-ester bond-forming
 IPR019742  Alpha-2-macroglobulin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000084 yolk yolk increased size , abnormal
Show

 ZFA:0000112 gut gut decreased size , abnormal
Show

 ZFA:0000123 liver liver decreased size , abnormal
liver vacuolated , abnormal
liver morphology , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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