ENSDARG00000041645


Danio rerio

Features
Gene ID: ENSDARG00000041645
  
Biological name :A2ML1 (1 of many)
  
Synonyms : A2ML1 (1 of many) / sb:cb37 / si:dkey-105h12.2
  
Possible biological names infered from orthology : A2ML1 / A8K2U0 / alpha-2-macroglobulin like 1
  
Species: Danio rerio
  
Chr. number: 15
Strand: -1
Band:
Gene start: 21137046
Gene end: 21155657
  
Corresponding Affymetrix probe sets: Dr.25331.1.S1_at (Zebrafish Array)   Dr.25331.2.A1_at (Zebrafish Array)   Dr.25379.1.S1_at (Zebrafish Array)   Dr.3025.2.S1_at (Zebrafish Array)   Dr.3025.3.S1_at (Zebrafish Array)   XM_001345505_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000046442
Ensembl peptide - ENSDARP00000061097
NCBI entrez gene - 100006972     See in Manteia.
RefSeq - XM_001345505
swissprot - F1R8N2
swissprot - E7F8T4
ZFIN ID - ZDB-GENE-030131-9800
ZFIN ID - ZDB-GENE-131118-9
Ensembl - ENSDARG00000041645
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000000293Gallus gallus
 ENSGALG00000014252Gallus gallus
 A2ML1ENSGALG00000036447Gallus gallus
 A2ML1ENSG00000166535Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
a2ml / alpha-2-macroglobulin-like / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000005631497
si:dkey-105h12.2 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000004168586
si:ch211-212c13.10 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000009319976
A2ML1 (1 of many) / si:ch211-212c13.8 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007875768
zgc:165518 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007573758
si:dkey-46g23.2 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011581757
zgc:171445 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011520557
zgc:171446 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011600557
si:dkey-46g23.5 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000000883557
zgc:165453 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007818356
zgc:171426 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007476433
cpamd8 / C3 and PZP-like, alpha-2-macroglobulin domain containing 8 / Q8IZJ3*ENSDARG0000005653025
cd109 / CD109 molecule / Q6YHK3* / Q8R422* / CD109 antigen *ENSDARG0000006060923
c4 / complement component 4 / C4A* / C4B* / P0C0L5* / P01029* / P0C0L4* / complement C4B (Chido blood group)* / complement C4A (Rodgers blood group)* / Complement C4-B Complement C4 beta ch...ENSDARG0000001506521
c3a.1 / complement component c3a, duplicate 1 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acyla...ENSDARG0000001269421
c3a.4 / complement component c3a, duplicate 4 / C3* / P01024* / complement C3*ENSDARG0000009319821
c3a.6 / complement component c3a, duplicate 6 / C3* / P01024* / complement C3*ENSDARG0000004371920
c3b.2 / complement component c3b, tandem duplicate 2 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxi...ENSDARG0000000181820
c3a.2 / complement component c3a, duplicate 2 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acyla...ENSDARG0000008735920
si:dkey-8k3.2ENSDARG0000003842420


Protein motifs (from Interpro)
Interpro ID Name
 IPR001599  Alpha-2-macroglobulin
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR013783  Immunoglobulin-like fold
 IPR014756  Immunoglobulin E-set
 IPR019565  Alpha-2-macroglobulin, thiol-ester bond-forming
 IPR019742  Alpha-2-macroglobulin, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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