ENSDARG00000021004


Danio rerio

Features
Gene ID: ENSDARG00000021004
  
Biological name :c5
  
Synonyms : c5 / complement component 5
  
Possible biological names infered from orthology : complement C5 / Hc / hemolytic complement / P01031 / P06684
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 63458263
Gene end: 63509581
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000088095
NCBI entrez gene - 565774     See in Manteia.
RefSeq - XM_001919191
swissprot - E7FCV2
ZFIN ID - ZDB-GENE-120510-2
Ensembl - ENSDARG00000021004
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 C5ENSGALG00000001565Gallus gallus
 C5ENSG00000106804Homo sapiens
 HcENSMUSG00000026874Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
c4 / complement component 4 / C4A* / C4B* / P0C0L5* / P01029* / P0C0L4* / complement C4B (Chido blood group)* / complement C4A (Rodgers blood group)* / Complement C4-B Complement C4 beta ch...ENSDARG0000001506525
c3a.1 / complement component c3a, duplicate 1 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acyla...ENSDARG0000001269424
c3a.6 / complement component c3a, duplicate 6 / C3* / P01024* / complement C3*ENSDARG0000004371924
c3b.2 / complement component c3b, tandem duplicate 2 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxi...ENSDARG0000000181824
c3a.3 / complement component c3a, duplicate 3 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acyla...ENSDARG0000005220724
c3b.1 / complement component c3b, tandem duplicate 1 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxi...ENSDARG0000009306824
c3a.2 / complement component c3a, duplicate 2 / C3* / P01024* / P01027* / complement C3* / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acyla...ENSDARG0000008735924
c3a.4 / complement component c3a, duplicate 4 / C3* / P01024* / complement C3*ENSDARG0000009319823
si:dkey-8k3.2ENSDARG0000003842422
cpamd8 / C3 and PZP-like, alpha-2-macroglobulin domain containing 8 / Q8IZJ3*ENSDARG0000005653018
zgc:165518 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007573715
cd109 / CD109 molecule / Q6YHK3* / Q8R422* / CD109 antigen *ENSDARG0000006060915
zgc:165453 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000007818315
sb:cb37 / si:dkey-105h12.2 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000004164515
zgc:171446 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011600515
a2ml / alpha-2-macroglobulin-like / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000005631415
zgc:171445 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011520515
si:dkey-46g23.5 / A2ML1 (1 of many) / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000000883515
si:dkey-46g23.2 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000011581715
si:ch211-212c13.10 / A2ML1* / A8K2U0* / alpha-2-macroglobulin like 1*ENSDARG0000009319914


Protein motifs (from Interpro)
Interpro ID Name
 IPR000020  Anaphylatoxin/fibulin
 IPR001134  Netrin domain
 IPR001599  Alpha-2-macroglobulin
 IPR002890  Alpha-2-macroglobulin, N-terminal
 IPR008930  Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR009048  Alpha-macroglobulin, receptor-binding
 IPR011625  Alpha-2-macroglobulin, N-terminal 2
 IPR011626  Alpha-macroglobulin complement component
 IPR013783  Immunoglobulin-like fold
 IPR018081  Anaphylatoxin, complement system
 IPR018933  Netrin module, non-TIMP type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0004866 endopeptidase inhibitor activity IEA


Pathways (from Reactome)
Pathway description
Terminal pathway of complement
Activation of C3 and C5
Peptide ligand-binding receptors
G alpha (i) signalling events
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000005616 bfb / complement component bfb / CFB* / P04186* / P00751* / Gm20547* / AL645922.1* / complement factor B* / Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment*  / reaction
 ENSDARG00000032098 c8g / complement component 8, gamma polypeptide / Q8VCG4* / P07360* / complement C8 gamma chain* / Complement component C8 gamma chain *  / reaction / complex
 ENSDARG00000015065 c4 / complement component 4 / C4A* / C4B* / P0C0L5* / P01029* / P0C0L4* / complement C4B (Chido blood group)* / complement C4A (Rodgers blood group)* / Complement C4-B Complement C4 beta ch...  / reaction
 ENSDARG00000036041 f2 / coagulation factor II (thrombin) / P00734* / P19221* / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain*  / reaction
 ENSDARG00000055278 cfb / complement factor B / P04186* / P00751* / Gm20547* / AL645922.1* / Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment*  / reaction
 ENSDARG00000037144 cpb2 / carboxypeptidase B2 (plasma) / Q96IY4* / Q9JHH6* / carboxypeptidase B2*  / reaction
 ENSDARG00000039517 c8b / complement component 8, beta polypeptide / P07358* / complement C8 beta chain*  / complex / reaction
 ENSDARG00000063518 zgc:153913 / CPN2* / P22792* / carboxypeptidase N subunit 2*  / reaction
 ENSDARG00000040319 P0C7U5 / CABZ01041494.1 / C5a anaphylatoxin chemotactic receptor 1 / C5AR1* / C5AR2* / Q9P296* / P21730* / complement C5a receptor 1* / complement component 5a receptor 2*  / reaction / complex
 ENSDARG00000053831 vtnb / vitronectin b / VTN* / P04004* / P29788* / AC002094.3* / vitronectin*  / reaction / complex
 ENSDARG00000039516 c8a / complement component 8, alpha polypeptide / P07357* / complement C8 alpha chain*  / reaction / complex
 ENSDARG00000021004 c5 / complement component 5 / P01031* / complement C5*  / complex
 ENSDARG00000057121 c7b / complement component 7b / C7* / P10643* / complement C7* / complement component 7*  / complex / reaction
 ENSDARG00000094451 cfp / complement factor properdin / P11680* / P27918*  / reaction
 ENSDARG00000078114 si:ch73-237c6.1 / CFP* / P11680* / P27918* / complement factor properdin*  / reaction
 ENSDARG00000016319 c9 / complement component 9 / P02748* / complement C9*  / reaction / complex






 

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