ENSDARG00000055278


Danio rerio

Features
Gene ID: ENSDARG00000055278
  
Biological name :cfb
  
Synonyms : cfb / complement factor B
  
Possible biological names infered from orthology : AL645922.1 / Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment / Gm20547 / P00751 / P04186
  
Species: Danio rerio
  
Chr. number: 21
Strand: 1
Band:
Gene start: 27416284
Gene end: 27431397
  
Corresponding Affymetrix probe sets: Dr.190.1.S1_at (Zebrafish Array)   NM_131338_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000098086
Ensembl peptide - ENSDARP00000072059
NCBI entrez gene - 30604     See in Manteia.
RefSeq - XM_021468751
RefSeq - NM_131338
RefSeq Peptide - NP_571413
swissprot - F1R886
swissprot - F1QFC2
ZFIN ID - ZDB-GENE-980526-487
Ensembl - ENSDARG00000055278
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 AL645922.1ENSG00000244255Homo sapiens
 CFBENSG00000243649Homo sapiens
 CfbENSMUSG00000090231Mus musculus
 Gm20547ENSMUSG00000092511Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cfbl / complement factor b-like / CFB* / P04186* / P00751* / Gm20547* / AL645922.1* / complement factor B* / Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment*ENSDARG0000009073055
bfb / complement component bfb / CFB* / P04186* / P00751* / Gm20547* / AL645922.1* / complement factor B* / Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment*ENSDARG0000000561646
si:ch1073-280e3.1 / C2* / P06681* / complement C2*ENSDARG0000001977229


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR002035  von Willebrand factor, type A
 IPR009003  Peptidase S1, PA clan
 IPR011360  Complement B/C2
 IPR018114  Serine proteases, trypsin family, histidine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006956 complement activation IEA
 biological_processGO:0009617 response to bacterium IDA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA


Pathways (from Reactome)
Pathway description
Alternative complement activation
Activation of C3 and C5
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000039579 cfd / complement factor D (adipsin) / P00746* / P03953* / complement factor D*  / reaction
 ENSDARG00000021004 c5 / complement component 5 / P01031* / complement C5*  / reaction
 ENSDARG00000094451 cfp / complement factor properdin / P11680* / P27918*  / complex / reaction
 ENSDARG00000078114 si:ch73-237c6.1 / CFP* / P11680* / P27918* / complement factor properdin*  / complex / reaction






 

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