ENSMUSG00000090231


Mus musculus

Features
Gene ID: ENSMUSG00000090231
  
Biological name :Cfb
  
Synonyms : Cfb / Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment / P04186
  
Possible biological names infered from orthology : AL645922.1 / complement factor B / P00751
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: B1
Gene start: 34856374
Gene end: 34862518
  
Corresponding Affymetrix probe sets: 10450325 (MoGene1.0st)   1417314_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120990
Ensembl peptide - ENSMUSP00000119977
Ensembl peptide - ENSMUSP00000135304
Ensembl peptide - ENSMUSP00000135660
Ensembl peptide - ENSMUSP00000025229
Ensembl peptide - ENSMUSP00000116497
Ensembl peptide - ENSMUSP00000118360
Ensembl peptide - ENSMUSP00000118945
NCBI entrez gene - 14962     See in Manteia.
MGI - MGI:105975
RefSeq - XM_006523672
RefSeq - NM_001142706
RefSeq - NM_008198
RefSeq - XM_006523671
RefSeq Peptide - NP_001136178
RefSeq Peptide - NP_032224
swissprot - B8JJM5
swissprot - Q3UEG8
swissprot - B8JJM3
swissprot - P04186
swissprot - B8JJM6
swissprot - F6W2T4
swissprot - F6XQ00
swissprot - F6WZA2
swissprot - H3BK95
Ensembl - ENSMUSG00000090231
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 bfbENSDARG00000005616Danio rerio
 cfbENSDARG00000055278Danio rerio
 cfblENSDARG00000090730Danio rerio
 AL645922.1ENSG00000244255Homo sapiens
 CFBENSG00000243649Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm20547 / CFB* / P00751* / AL645922.1* / complement factor B*ENSMUSG0000009251198
C2 / P21180 / Complement C2 Complement C2b fragment Complement C2a fragment / P06681* / complement C2*ENSMUSG0000002437137


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR002035  von Willebrand factor, type A
 IPR009003  Peptidase S1, PA clan
 IPR011360  Complement B/C2
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR028341  Complement factor B
 IPR033116  Serine proteases, trypsin family, serine active site
 IPR035976  Sushi/SCR/CCP superfamily
 IPR036465  von Willebrand factor A-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006956 complement activation IEA
 biological_processGO:0006957 complement activation, alternative pathway TAS
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Alternative complement activation
Activation of C3 and C5
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdkn2dtm1Maro/Cdkn2dtm1Maro
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fcgr1tm1Jsv/Fcgr1tm1Jsv,Fcgr2btm1Ttk/Fcgr2btm1Ttk,Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0002471 abnormal complement cascade "impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0002472 impaired complement alternative pathway "abnormal function of the plasma protein cascade triggered by direct contact with pathogen surfaces" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Maftm1Glm/Maftm1Glm
Genetic Background: involves: 129/Sv * BALB/c

 MP:0002473 impaired complement classical pathway "abnormal function of the plasma protein cascade triggered by antigen:antibody complexes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Mxi1tm1Rdp/Mxi1tm1Rdp
Genetic Background: involves: 129/Sv * C57BL/6J * SJL

 MP:0005416 abnormal circulating protein level "anomalous blood concentration of any of the macromolecules consisting of long chains of amino acids in peptide linkage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cfhtm1Mbo/Cfh+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005564 increased hemoglobin content "increase in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, RGD:Rat Genome Database submission]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0020518 renal glomerular protein deposits "any anomalous accumulation of protein in the renal glomerulus" [HP:0030949]
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Allelic Composition: Cfbtm1Hrc/Cfb+,Cfhtm1Mbo/Cfhtm1Mbo
Genetic Background: involves: 129S/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026399 Cd55 / Q61475 / Complement decay-accelerating factor, GPI-anchored / P08174* / CD55 molecule (Cromer blood group)*  / reaction / complex
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / reaction / complex
 ENSMUSG00000026401 Cd55b / CD55* / P08174* / CD55 molecule (Cromer blood group)*  / complex / reaction
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction
 ENSMUSG00000001128 Cfp / P11680 / complement factor properdin / P27918*  / reaction / complex
 ENSMUSG00000061780 Cfd / P03953 / Complement factor D / P00746*  / reaction






 

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