ENSMUSG00000026399


Mus musculus

Features
Gene ID: ENSMUSG00000026399
  
Biological name :Cd55
  
Synonyms : Cd55 / Complement decay-accelerating factor, GPI-anchored / Q61475
  
Possible biological names infered from orthology : CD55 molecule (Cromer blood group) / P08174
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 130439027
Gene end: 130462744
  
Corresponding Affymetrix probe sets: 10357488 (MoGene1.0st)   1418762_at (Mouse Genome 430 2.0 Array)   1427632_x_at (Mouse Genome 430 2.0 Array)   1443906_at (Mouse Genome 430 2.0 Array)   1460242_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027650
Ensembl peptide - ENSMUSP00000122294
NCBI entrez gene - 13136     See in Manteia.
MGI - MGI:104850
RefSeq - XM_017314336
RefSeq - NM_010016
RefSeq - XM_006529116
RefSeq - XM_006529117
RefSeq - XM_017314303
RefSeq - XM_006529115
RefSeq Peptide - NP_034146
swissprot - Q61475
swissprot - F7BP06
Ensembl - ENSMUSG00000026399
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rca2.1ENSDARG00000056075Danio rerio
 rca2.2ENSDARG00000095512Danio rerio
 CD55ENSG00000196352Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd55b / CD55* / P08174* / CD55 molecule (Cromer blood group)*ENSMUSG0000002640180
Zp3r / zona pellucida 3 receptorENSMUSG0000004255424
C4bp / P08607 / C4b-binding protein ENSMUSG0000002640523
Cfh / P06909 / Complement factor H / CFHR3* / CFHR4* / Q92496* / P08603* / Q02985* / complement factor H related 4* / complement factor H related 3*ENSMUSG0000002636519
Cd46 / O88174 / Membrane cofactor protein / P15529* / CD46 molecule*ENSMUSG0000001649318
Apoh / Q01339 / Beta-2-glycoprotein 1 / P02749* / apolipoprotein H*ENSMUSG0000000004915
Gm4788 / complement factor H-related protein C isoform 2 / CFH* / CFHR4* / CFHR3* / Q92496* / P08603* / Q02985* / complement factor H* / complement factor H related 3* / complement factor ...ENSMUSG0000007059415
Selp / Q01102 / selectin, platelet / P16109* / selectin P*ENSMUSG0000002658015
Sele / selectin, endothelial cell / P16581* / selectin E*ENSMUSG0000002658214
F13b / Q07968 / Coagulation factor XIII B chain / P05160*ENSMUSG0000002636814
Sell / P18337 / selectin, lymphocyte / P14151* / selectin L*ENSMUSG0000002658113
Cfhr2 / complement factor H-related 2 / CFH* / CFHR3* / CFHR4* / Q92496* / P08603* / Q02985* / complement factor H* / complement factor H related 4* / complement factor H related 3*ENSMUSG0000003389811
Cfhr1 / complement factor H-related 1 / CFHR5* / CFHR2* / P36980* / Q9BXR6* / Q03591* / BX248415.1* / complement factor H related 5* / complement factor H related 2*ENSMUSG000000570379


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0030450 regulation of complement activation, classical pathway IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045916 negative regulation of complement activation ISS
 biological_processGO:0046718 viral entry into host cell IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0045121 membrane raft ISO
 molecular_functionGO:0001618 virus receptor activity ISO
 molecular_functionGO:0008289 lipid binding ISO


Pathways (from Reactome)
Pathway description
Class B/2 (Secretin family receptors)
Neutrophil degranulation
COPI-mediated anterograde transport
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Cd55tm1Song/Cd55tm1Song
Genetic Background: B6.129S6-Cd55tm1Song

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cd55tm1Song/Cd55tm1Song
Genetic Background: B6.129S6-Cd55tm1Song

 MP:0002471 abnormal complement cascade "impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hexatm1Cota/Hexatm1Cota
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cd59atm1Song/Cd59atm1Song,Cd55tm1Song/Cd55tm1Song
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cd55tm1Song/Cd55tm1Song
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Cd55tm1Song/Cd55tm1Song,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd55tm1Song Cd59atm1Bpm

 MP:0002472 impaired complement alternative pathway "abnormal function of the plasma protein cascade triggered by direct contact with pathogen surfaces" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hexatm1Cota/Hexatm1Cota
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002473 impaired complement classical pathway "abnormal function of the plasma protein cascade triggered by antigen:antibody complexes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Hexatm1Cota/Hexatm1Cota
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Cd55tm1Song/Cd55tm1Song,Cr1ltm1Hmo/Cr1ltm1Hmo,Vsig4tm1Gne/Vsig4tm1Gne
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
Show

Allelic Composition: Cd55tm1Song/Cd55tm1Song,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd55tm1Song Cd59atm1Bpm

 MP:0004823 increased susceptibility to experimental autoimmune myasthenia gravis "greater likelihood that an organism will develop disease symptoms similar to human myasthenia gravis upon induction with antigens to acetylcholine receptor subunits" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Cd55tm1Song/Cd55tm1Song,Cr1ltm1Hmo/Cr1ltm1Hmo,Vsig4tm1Gne/Vsig4tm1Gne
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N

Allelic Composition: Cd55tm1Song/Cd55tm1Song
Genetic Background: B6.129S6-Cd55tm1Song

Allelic Composition: Cd55tm1Song/Cd55tm1Song,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd55tm1Song Cd59atm1Bpm

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Cd55tm1Song/Cd55tm1Song,Cr1ltm1Hmo/Cr1ltm1Hmo,Vsig4tm1Gne/Vsig4tm1Gne
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
Show

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Cd55tm1Song/Cd55tm1Song,Cr1ltm1Hmo/Cr1ltm1Hmo,Vsig4tm1Gne/Vsig4tm1Gne
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Npr2cn/Npr2slw
Genetic Background: involves: AKR/J * C57BL/6 * DDY

Allelic Composition: C3tm1Hrc/C3tm1Hrc,Cd55tm1Song/Cd55tm1Song,Cr1ltm1Hmo/Cr1ltm1Hmo,Vsig4tm1Gne/Vsig4tm1Gne
Genetic Background: involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd55tm1Song/Cd55tm1Song,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd55tm1Song Cd59atm1Bpm

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Cd55tm1Song/Cd55tm1Song
Genetic Background: B6.129S6-Cd55tm1Song

Allelic Composition: Cd55tm1Song/Cd55tm1Song,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd55tm1Song Cd59atm1Bpm

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024371 C2 / P21180 / Complement C2 Complement C2b fragment Complement C2a fragment / P06681* / complement C2*  / complex / reaction
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / reaction / complex
 ENSMUSG00000026399 Cd55 / Q61475 / Complement decay-accelerating factor, GPI-anchored / P08174* / CD55 molecule (Cromer blood group)*  / reaction
 ENSMUSG00000090231 Cfb / P04186 / Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment / P00751* / AL645922.1* / complement factor B*  / reaction / complex
 ENSMUSG00000026401 Cd55b / CD55* / P08174* / CD55 molecule (Cromer blood group)*  / reaction
 ENSMUSG00000073418 C4b / P01029 / Complement C4-B Complement C4 beta chain Complement C4 alpha chain C4a anaphylatoxin Complement C4 gamma chain / C4A* / P0C0L4* / P0C0L5* / complement C4B (Chido blood group)...  / complex / reaction






 

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