ENSMUSG00000000049


Mus musculus

Features
Gene ID: ENSMUSG00000000049
  
Biological name :Apoh
  
Synonyms : Apoh / Beta-2-glycoprotein 1 / Q01339
  
Possible biological names infered from orthology : apolipoprotein H / P02749
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: E1
Gene start: 108343354
Gene end: 108414396
  
Corresponding Affymetrix probe sets: 10382189 (MoGene1.0st)   1416677_at (Mouse Genome 430 2.0 Array)   1447719_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000049
Ensembl peptide - ENSMUSP00000114214
Ensembl peptide - ENSMUSP00000115516
Ensembl peptide - ENSMUSP00000123486
NCBI entrez gene - 11818     See in Manteia.
MGI - MGI:88058
RefSeq - XM_006532042
RefSeq - NM_013475
RefSeq Peptide - NP_038503
swissprot - I7HPW5
swissprot - I7HJR3
swissprot - Q01339
swissprot - J3JS85
Ensembl - ENSMUSG00000000049
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APOHENSGALG00000033376Gallus gallus
 APOHENSG00000091583Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Zp3r / zona pellucida 3 receptorENSMUSG0000004255425
C4bp / P08607 / C4b-binding protein ENSMUSG0000002640523
Selp / Q01102 / selectin, platelet / P16109* / selectin P*ENSMUSG0000002658021
Cd46 / O88174 / Membrane cofactor protein / P15529* / CD46 molecule*ENSMUSG0000001649321
Cfh / P06909 / Complement factor H / CFHR3* / CFHR4* / Q92496* / P08603* / Q02985* / complement factor H related 4* / complement factor H related 3*ENSMUSG0000002636521
F13b / Q07968 / Coagulation factor XIII B chain / P05160*ENSMUSG0000002636820
Gm4788 / complement factor H-related protein C isoform 2 / CFH* / CFHR4* / CFHR3* / Q92496* / P08603* / Q02985* / complement factor H* / complement factor H related 3* / complement factor ...ENSMUSG0000007059419
Sele / selectin, endothelial cell / P16581* / selectin E*ENSMUSG0000002658217
Cd55 / Q61475 / Complement decay-accelerating factor, GPI-anchored / P08174* / CD55 molecule (Cromer blood group)*ENSMUSG0000002639917
Cd55b / CD55* / P08174* / CD55 molecule (Cromer blood group)*ENSMUSG0000002640117
Sell / P18337 / selectin, lymphocyte / P14151* / selectin L*ENSMUSG0000002658112
Cfhr1 / complement factor H-related 1 / CFHR5* / CFHR2* / P36980* / Q9BXR6* / Q03591* / BX248415.1* / complement factor H related 5* / complement factor H related 2*ENSMUSG0000005703710
Cfhr2 / complement factor H-related 2 / CFH* / CFHR3* / CFHR4* / Q92496* / P08603* / Q02985* / complement factor H* / complement factor H related 4* / complement factor H related 3*ENSMUSG000000338988


Protein motifs (from Interpro)
Interpro ID Name
 IPR000436  Sushi/SCR/CCP domain
 IPR015104  Beta-2-glycoprotein-1 fifth domain
 IPR035976  Sushi/SCR/CCP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001937 negative regulation of endothelial cell proliferation IEA
 biological_processGO:0006641 triglyceride metabolic process IEA
 biological_processGO:0007597 blood coagulation, intrinsic pathway IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0030193 regulation of blood coagulation IMP
 biological_processGO:0030195 negative regulation of blood coagulation IEA
 biological_processGO:0031639 plasminogen activation IEA
 biological_processGO:0033033 negative regulation of myeloid cell apoptotic process IEA
 biological_processGO:0034392 negative regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0051006 positive regulation of lipoprotein lipase activity IEA
 biological_processGO:0051917 regulation of fibrinolysis IEA
 biological_processGO:0051918 negative regulation of fibrinolysis IEA
 cellular_componentGO:0005576 extracellular region ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0034361 very-low-density lipoprotein particle IEA
 cellular_componentGO:0034364 high-density lipoprotein particle IEA
 cellular_componentGO:0042627 chylomicron IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0060230 lipoprotein lipase activator activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Apoa2tm1Bres/Apoa2+,Apoetm1Bres/Apoetm1Bres
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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