ENSMUSG00000001128


Mus musculus

Features
Gene ID: ENSMUSG00000001128
  
Biological name :Cfp
  
Synonyms : Cfp / complement factor properdin / P11680
  
Possible biological names infered from orthology : P27918
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: A1.3
Gene start: 20925454
Gene end: 20931555
  
Corresponding Affymetrix probe sets: 10603860 (MoGene1.0st)   1452279_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001156
NCBI entrez gene - 18636     See in Manteia.
MGI - MGI:97545
RefSeq - NM_008823
RefSeq Peptide - NP_032849
swissprot - A2AE15
swissprot - P11680
Ensembl - ENSMUSG00000001128
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cfpENSDARG00000094451Danio rerio
 si:ch73-237c6.1ENSDARG00000078114Danio rerio
 CFPENSG00000126759Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adgrb1 / Q3UHD1 / Adhesion G protein-coupled receptor B1 Vasculostatin-120 Vasculostatin-40 / O14514* / adhesion G protein-coupled receptor B1*ENSMUSG0000003473030
Adgrb2 / Q8CGM1 / Adhesion G protein-coupled receptor B2 / O60241*ENSMUSG0000002878228
Adgrb3 / Q80ZF8 / Adhesion G protein-coupled receptor B3 / O60242*ENSMUSG0000003356928
Adgrf5 / G5E8Q8 / Mus musculus adhesion G protein-coupled receptor F5 (Adgrf5), transcript variant 2, mRNA. / Q8IZF2* / adhesion G protein-coupled receptor F5*ENSMUSG0000005649216
Adgrf3 / Q58Y75 / Adhesion G-protein coupled receptor F3 / Q8IZF5*ENSMUSG0000006764213
Adgrf1 / Q8VEC3 / Adhesion G-protein coupled receptor F1 / Q5T601*ENSMUSG000000412938
Adgrf4 / adhesion G protein-coupled receptor F4 / Q8IZF3*ENSMUSG000000239187
Adgrf2 / E9Q4J9 / Adhesion G-protein coupled receptor F2 / Q8IZF7*ENSMUSG000000578995


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006957 complement activation, alternative pathway IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0031012 extracellular matrix IEA


Pathways (from Reactome)
Pathway description
Alternative complement activation
Activation of C3 and C5
O-glycosylation of TSR domain-containing proteins
Neutrophil degranulation
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ptentm1Mro/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae

 MP:0002471 abnormal complement cascade "impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae

 MP:0002472 impaired complement alternative pathway "abnormal function of the plasma protein cascade triggered by direct contact with pathogen surfaces" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cfptm2.1Song/Cfptm2.1Song,Tg(EIIa-cre)C5379Lmgd/0
Genetic Background: involves: 129 * C57BL/6 * FVB/N * SJL

Allelic Composition: Cfptm2.1Song/Cfptm2.1Song,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Cfptm1Song/Cfptm1Song
Genetic Background: involves: 129 * C57BL/6

 MP:0002473 impaired complement classical pathway "abnormal function of the plasma protein cascade triggered by antigen:antibody complexes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Itktm1Litt/Itktm1Litt
Genetic Background: involves: 129S4/SvJae

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
Show

Allelic Composition: Cfptm2.1Song/Cfptm2.1Song,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * SJL

Allelic Composition: Cfptm1Song/Cfptm1Song
Genetic Background: involves: 129 * C57BL/6

 MP:0005044 sepsis "presence of various pathogenic organisms, or their toxins, in the blood or tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:82434]
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Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ptentm1Mro/Pten+,Tg(Pbsn-cre)4Prb/0
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Insrtm1Khn/Insrtm1Khn,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA/2

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction
 ENSMUSG00000001128 Cfp / P11680 / complement factor properdin / P27918*  / -
 ENSMUSG00000090231 Cfb / P04186 / Complement factor B Complement factor B Ba fragment Complement factor B Bb fragment / P00751* / AL645922.1* / complement factor B*  / complex / reaction
 ENSMUSG00000024164 C3 / P01027 / Complement C3 Complement C3 beta chain C3-beta-c Complement C3 alpha chain C3a anaphylatoxin Acylation stimulating protein Complement C3b alpha chain Complement C3c alpha chain...  / complex / reaction






 

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