ENSMUSG00000034730


Mus musculus

Features
Gene ID: ENSMUSG00000034730
  
Biological name :Adgrb1
  
Synonyms : Adgrb1 / Adhesion G protein-coupled receptor B1 Vasculostatin-120 Vasculostatin-40 / Q3UHD1
  
Possible biological names infered from orthology : adhesion G protein-coupled receptor B1 / O14514
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D3
Gene start: 74516195
Gene end: 74589465
  
Corresponding Affymetrix probe sets: 10424624 (MoGene1.0st)   1455363_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000127122
Ensembl peptide - ENSMUSP00000140959
Ensembl peptide - ENSMUSP00000140889
Ensembl peptide - ENSMUSP00000140831
Ensembl peptide - ENSMUSP00000140407
Ensembl peptide - ENSMUSP00000140362
Ensembl peptide - ENSMUSP00000139428
Ensembl peptide - ENSMUSP00000046097
NCBI entrez gene - 107831     See in Manteia.
MGI - MGI:1933736
RefSeq - XM_006520271
RefSeq - XM_006520276
RefSeq - XM_011245403
RefSeq - XM_011245404
RefSeq - XM_011245405
RefSeq - XM_011245406
RefSeq - NM_174991
RefSeq - XM_006520269
RefSeq - XM_006520270
RefSeq Peptide - NP_778156
swissprot - Q3UHD1
swissprot - A0A087WSA1
swissprot - A0A087WS42
swissprot - A0A087WRZ4
swissprot - A0A087WQZ5
swissprot - A0A087WQV8
swissprot - E9Q4H5
Ensembl - ENSMUSG00000034730
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adgrb1aENSDARG00000075133Danio rerio
 adgrb1bENSDARG00000078529Danio rerio
 ADGRB1ENSGALG00000033960Gallus gallus
 ADGRB1ENSG00000181790Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adgrb3 / Q80ZF8 / Adhesion G protein-coupled receptor B3 / O60242*ENSMUSG0000003356947
Adgrb2 / Q8CGM1 / Adhesion G protein-coupled receptor B2 / O60241*ENSMUSG0000002878242
Adgrf5 / G5E8Q8 / Mus musculus adhesion G protein-coupled receptor F5 (Adgrf5), transcript variant 2, mRNA. / Q8IZF2* / adhesion G protein-coupled receptor F5*ENSMUSG0000005649213
Adgrf1 / Q8VEC3 / Adhesion G-protein coupled receptor F1 / Q5T601*ENSMUSG0000004129311
Adgrf3 / Q58Y75 / Adhesion G-protein coupled receptor F3 / Q8IZF5*ENSMUSG0000006764210
Cfp / P11680 / complement factor properdin / P27918*ENSMUSG000000011289
Adgrf4 / adhesion G protein-coupled receptor F4 / Q8IZF3*ENSMUSG000000239188
Adgrf2 / E9Q4J9 / Adhesion G-protein coupled receptor F2 / Q8IZF7*ENSMUSG000000578997


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000832  GPCR, family 2, secretin-like
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR008077  GPCR, family 2, brain-specific angiogenesis inhibitor
 IPR017981  GPCR, family 2-like
 IPR032471  GAIN domain, N-terminal
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006909 phagocytosis IEA
 biological_processGO:0006910 phagocytosis, recognition IMP
 biological_processGO:0006911 phagocytosis, engulfment IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0010596 negative regulation of endothelial cell migration IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0042177 negative regulation of protein catabolic process IMP
 biological_processGO:0043277 apoptotic cell clearance IEA
 biological_processGO:0043652 engulfment of apoptotic cell IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0048167 regulation of synaptic plasticity IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 biological_processGO:0051965 positive regulation of synapse assembly IDA
 biological_processGO:1901741 positive regulation of myoblast fusion IMP
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process IEA
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001530 lipopolysaccharide binding IDA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030165 PDZ domain binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky/Gt(ROSA)26Sor+
Genetic Background: C57BL/6N-Gt(ROSA)26Sorem1(CAG-cas9*,-EGFP)Rsky

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Adgrb1tm2a(EUCOMM)Wtsi/Adgrb1+
Genetic Background: C57BL/6N-Adgrb1tm2a(EUCOMM)Wtsi/Wtsi

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Adgrb1tm2a(EUCOMM)Wtsi/Adgrb1+
Genetic Background: C57BL/6N-Adgrb1tm2a(EUCOMM)Wtsi/Wtsi

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Adgrb1tm2a(EUCOMM)Wtsi/Adgrb1+
Genetic Background: C57BL/6N-Adgrb1tm2a(EUCOMM)Wtsi/Wtsi

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013023 decreased Ly6C high monocyte number "decrease in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak]
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Allelic Composition: Nbeal2tm1a(EUCOMM)Wtsi/Nbeal2tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nbeal2tm1a(EUCOMM)Wtsi/Wtsi

Allelic Composition: Adgrb1tm2a(EUCOMM)Wtsi/Adgrb1+
Genetic Background: C57BL/6N-Adgrb1tm2a(EUCOMM)Wtsi/Wtsi

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
Show

Allelic Composition: Adgrb1tm2a(EUCOMM)Wtsi/Adgrb1+
Genetic Background: C57BL/6N-Adgrb1tm2a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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