ENSDARG00000039517


Danio rerio

Features
Gene ID: ENSDARG00000039517
  
Biological name :c8b
  
Synonyms : c8b / complement component 8, beta polypeptide
  
Possible biological names infered from orthology : complement C8 beta chain / Complement component C8 beta chain / P07358 / Q8BH35
  
Species: Danio rerio
  
Chr. number: 2
Strand: -1
Band:
Gene start: 1478225
Gene end: 1518360
  
Corresponding Affymetrix probe sets: Dr.6349.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000151168
Ensembl peptide - ENSDARP00000057735
NCBI entrez gene - 793127     See in Manteia.
RefSeq - NM_001256723
RefSeq Peptide - NP_001243652
swissprot - A8HAJ8
ZFIN ID - ZDB-GENE-070912-163
Ensembl - ENSDARG00000039517
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 C8BENSGALG00000010853Gallus gallus
 C8BENSG00000021852Homo sapiens
 C8bENSMUSG00000029656Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
c7b / complement component 7b / C7* / P10643* / complement C7* / complement component 7*ENSDARG0000005712130
c9 / complement component 9 / P02748* / complement C9*ENSDARG0000001631928
c6 / complement component 6 / P13671* / complement C6*ENSDARG0000005711328
c8a / complement component 8, alpha polypeptide / P07357* / complement C8 alpha chain*ENSDARG0000003951628
c7a / complement component 7a / C7* / P10643* / complement C7* / complement component 7*ENSDARG0000004217227
c6 / complement component 6 / P13671* / complement C6*ENSDARG0000009305227


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001862  Membrane attack complex component/perforin/complement C9
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR020863  Membrane attack complex component/perforin domain, conserved site
 IPR020864  Membrane attack complex component/perforin (MACPF) domain
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006956 complement activation IEA
 cellular_componentGO:0005579 membrane attack complex IEA


Pathways (from Reactome)
Pathway description
Terminal pathway of complement
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000021004 c5 / complement component 5 / P01031* / complement C5*  / complex / reaction
 ENSDARG00000057121 c7b / complement component 7b / C7* / P10643* / complement C7* / complement component 7*  / complex / reaction
 ENSDARG00000053831 vtnb / vitronectin b / VTN* / P04004* / P29788* / AC002094.3* / vitronectin*  / reaction / complex
 ENSDARG00000032098 c8g / complement component 8, gamma polypeptide / Q8VCG4* / P07360* / complement C8 gamma chain* / Complement component C8 gamma chain *  / complex
 ENSDARG00000039516 c8a / complement component 8, alpha polypeptide / P07357* / complement C8 alpha chain*  / complex
 ENSDARG00000016319 c9 / complement component 9 / P02748* / complement C9*  / reaction / complex






 

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