ENSMUSG00000029656


Mus musculus

Features
Gene ID: ENSMUSG00000029656
  
Biological name :C8b
  
Synonyms : C8b / Complement component C8 beta chain / Q8BH35
  
Possible biological names infered from orthology : complement C8 beta chain / P07358
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C6
Gene start: 104766317
Gene end: 104804548
  
Corresponding Affymetrix probe sets: 10506454 (MoGene1.0st)   1427472_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031663
Ensembl peptide - ENSMUSP00000066940
NCBI entrez gene - 110382     See in Manteia.
MGI - MGI:88236
RefSeq - NM_001316671
RefSeq - NM_133882
RefSeq Peptide - NP_001303600
RefSeq Peptide - NP_598643
swissprot - Q8BH35
Ensembl - ENSMUSG00000029656
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c8bENSDARG00000039517Danio rerio
 C8BENSGALG00000010853Gallus gallus
 C8BENSG00000021852Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C8a / Q8K182 / Complement component C8 alpha chain / P07357* / complement C8 alpha chain*ENSMUSG0000003503132
C6 / complement component 6 / P13671* / complement C6*ENSMUSG0000002218128
C9 / complement C9 / P02748*ENSMUSG0000002214926
C7 / complement component 7 / P10643* / complement C7*ENSMUSG0000007910524


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001862  Membrane attack complex component/perforin/complement C9
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR016186  C-type lectin-like/link domain superfamily
 IPR020863  Membrane attack complex component/perforin domain, conserved site
 IPR020864  Membrane attack complex component/perforin (MACPF) domain
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR036055  LDL receptor-like superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily
 IPR037566  Complement component C8 beta chain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006956 complement activation IEA
 biological_processGO:0006957 complement activation, alternative pathway IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0019835 cytolysis IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005579 membrane attack complex ISO
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Terminal pathway of complement
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hoxa13tm2Ipc/Hoxa13tm2Ipc,Hoxd13tm1Ddu/Hoxd13tm1Ddu
Genetic Background: either: (involves: 129/Sv * 129S2/SvPas) or (involves: 129S2/SvPas * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015083 C8g / Q8VCG4 / Complement component C8 gamma chain / P07360* / complement C8 gamma chain*  / complex
 ENSMUSG00000022037 Clu / Q06890 / Clusterin Clusterin beta chain Clusterin alpha chain / P10909* / clusterin*  / reaction / complex
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction / complex
 ENSMUSG00000022181 C6 / complement component 6 / P13671* / complement C6*  / complex / reaction
 ENSMUSG00000079105 C7 / complement component 7 / P10643* / complement C7*  / complex / reaction
 ENSMUSG00000035031 C8a / Q8K182 / Complement component C8 alpha chain / P07357* / complement C8 alpha chain*  / complex
 ENSMUSG00000017344 Vtn / P29788 / vitronectin / P04004*  / complex / reaction
 ENSMUSG00000068686 Cd59b / P58019 / CD59B glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / reaction / complex
 ENSMUSG00000032679 Cd59a / O55186 / CD59A glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / reaction / complex
 ENSMUSG00000022149 C9 / complement C9 / P02748*  / complex / reaction






 

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