ENSMUSG00000068686


Mus musculus

Features
Gene ID: ENSMUSG00000068686
  
Biological name :Cd59b
  
Synonyms : Cd59b / CD59B glycoprotein / P58019
  
Possible biological names infered from orthology : AL049629.2 / CD59 / CD59 glycoprotein / CD59 molecule (CD59 blood group) / P13987
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E2
Gene start: 104069849
Gene end: 104091187
  
Corresponding Affymetrix probe sets: 10474223 (MoGene1.0st)   1418710_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106760
Ensembl peptide - ENSMUSP00000106762
Ensembl peptide - ENSMUSP00000117553
Ensembl peptide - ENSMUSP00000087912
Ensembl peptide - ENSMUSP00000106761
NCBI entrez gene - 333883     See in Manteia.
MGI - MGI:1888996
RefSeq - XM_017319062
RefSeq - NM_181858
RefSeq - XM_006499802
RefSeq - XM_006499803
RefSeq - XM_006499804
RefSeq - XM_006499805
RefSeq - XM_006499801
RefSeq Peptide - NP_862906
swissprot - P58019
swissprot - Q6PBG1
swissprot - A2BI28
Ensembl - ENSMUSG00000068686
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040371Gallus gallus
 CD59ENSG00000085063Homo sapiens
 P13987ENSG00000284969Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd59a / O55186 / CD59A glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*ENSMUSG0000003267964


Protein motifs (from Interpro)
Interpro ID Name
 IPR016054  Ly-6 antigen/uPA receptor-like
 IPR027101  CD59 glycoprotein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001775 cell activation IBA
 biological_processGO:0001971 negative regulation of activation of membrane attack complex IDA
 biological_processGO:0007166 cell surface receptor signaling pathway IBA
 biological_processGO:0045916 negative regulation of complement activation IDA
 biological_processGO:0045918 negative regulation of cytolysis IDA
 cellular_componentGO:0005576 extracellular region IBA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane ISO
 molecular_functionGO:0001848 complement binding IBA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Cargo concentration in the ER
Neutrophil degranulation
COPI-mediated anterograde transport
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0000256 echinocytosis "a state in which the red blood cells have multiple small projections appearing over the cell circumference resembling a small burr or a sea urchin" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0000314 schistocytosis "the appearance of poikilocytes in the blood that owe their abnormal shape to fragmentation occurring as the cells flow through damaged small vessels" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0000315 hemoglobinuria "the presence of hemoglobin in the urine, including certain closely related pigments that are formed from slight alteration of the hemoglobin molecule" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0000327 hemosiderinuria "the presence of hemosiderin in the urine; hemosiderin is an intracellular storage form of iron, found in the form of pigmented yellow to brown granules consisting of a complex of ferric hydroxides, polysaccharides, and proteins with an iron content of about 33 per cent by weight" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:82330]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0000332 hemoglobinemia "the presence of free hemoglobin in the blood plasma, an indication of significant intravascular hemolysis" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:82330]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0002641 anisopoikilocytosis "presence in blood of RBCs of abnormal shapes and sizes" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0005096 erythroblastosis "presence of erythroblasts in great number in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:305]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0005464 abnormal platelet physiology "atypical response of the non-nucleated cells found in the blood and involved in blood coagulation" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0008995 early reproductive senescence "loss of reproductive capacity occurring at an earlier than expected age" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0009230 abnormal sperm head morphology "any structural abnormality of the head segment of the sperm cell which contains the nucleus with densely coiled chromatin fibers, and is surrounded anteriorly by the acrosome which contains enzymes used for penetrating the female egg" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0009234 absent sperm head "absence of the head segment of the sperm cell" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0009325 necrospermia "condition in which spermatozoa in seminal fluid are dead or motionless" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

 MP:0020550 multinucleated giant male germ cells "presence of large cells containing multiple nuclei formed abnormal opening of the cytoplasmic bridges that are part of normal germ cell division" [PMID:16272280, url:https://ntp.niehs.nih.gov/nnl/male_reproductive/testis/setubmgcel/index.htm]
Show

Allelic Composition: Leprtm1Mgmj/Leprtm1Mgmj
Genetic Background: B6.129-Leprtm1Mgmj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015083 C8g / Q8VCG4 / Complement component C8 gamma chain / P07360* / complement C8 gamma chain*  / reaction / complex
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction / complex
 ENSMUSG00000022149 C9 / complement C9 / P02748*  / complex / reaction
 ENSMUSG00000022181 C6 / complement component 6 / P13671* / complement C6*  / complex / reaction
 ENSMUSG00000029656 C8b / Q8BH35 / Complement component C8 beta chain / P07358* / complement C8 beta chain*  / complex / reaction
 ENSMUSG00000021248 Q9D1D4 / Tmed10 / Transmembrane emp24 domain-containing protein 10 / P49755* / transmembrane p24 trafficking protein 10*  / complex / reaction
 ENSMUSG00000035031 C8a / Q8K182 / Complement component C8 alpha chain / P07357* / complement C8 alpha chain*  / complex / reaction
 ENSMUSG00000029390 Tmed2 / Q9R0Q3 / transmembrane p24 trafficking protein 2 / Q15363*  / complex / reaction
 ENSMUSG00000079105 C7 / complement component 7 / P10643* / complement C7*  / reaction / complex






 

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