ENSMUSG00000029390


Mus musculus

Features
Gene ID: ENSMUSG00000029390
  
Biological name :Tmed2
  
Synonyms : Q9R0Q3 / Tmed2 / transmembrane p24 trafficking protein 2
  
Possible biological names infered from orthology : Q15363
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 124540695
Gene end: 124550506
  
Corresponding Affymetrix probe sets: 10425114 (MoGene1.0st)   10525744 (MoGene1.0st)   10584162 (MoGene1.0st)   1420867_at (Mouse Genome 430 2.0 Array)   1420868_s_at (Mouse Genome 430 2.0 Array)   1431036_a_at (Mouse Genome 430 2.0 Array)   1436451_a_at (Mouse Genome 430 2.0 Array)   1436452_x_at (Mouse Genome 430 2.0 Array)   1455968_x_at (Mouse Genome 430 2.0 Array)   1460128_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054834
Ensembl peptide - ENSMUSP00000115169
Ensembl peptide - ENSMUSP00000142701
Ensembl peptide - ENSMUSP00000120809
NCBI entrez gene - 100862175     See in Manteia.
NCBI entrez gene - 56334     See in Manteia.
MGI - MGI:1929269
RefSeq - NM_019770
RefSeq Peptide - NP_062744
swissprot - Q8BPI2
swissprot - A2RS53
swissprot - Q9R0Q3
swissprot - A0A0G2JEB1
swissprot - F6V6T4
Ensembl - ENSMUSG00000029390
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmed2ENSDARG00000026908Danio rerio
 TMED2ENSGALG00000003307Gallus gallus
 TMED2ENSG00000086598Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tmed7 / transmembrane p24 trafficking protein 7 / Q9Y3B3*ENSMUSG0000003318435
Tmed3 / Q78IS1 / Transmembrane emp24 domain-containing protein 3 / Q9Y3Q3* / transmembrane p24 trafficking protein 3*ENSMUSG0000003235331
Tmed5 / Q9CXE7 / transmembrane p24 trafficking protein 5 / Q9Y3A6*ENSMUSG0000006340628
Tmed1 / Q3V009 / transmembrane p24 trafficking protein 1 / Q13445*ENSMUSG0000003218022


Protein motifs (from Interpro)
Interpro ID Name
 IPR009038  GOLD domain
 IPR015720  TMP21-related
 IPR036598  GOLD domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0001843 neural tube closure IMP
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0001893 maternal placenta development IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0007030 Golgi organization ISS
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0032525 somite rostral/caudal axis specification IMP
 biological_processGO:0034260 negative regulation of GTPase activity ISS
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0036342 post-anal tail morphogenesis IMP
 biological_processGO:0048598 embryonic morphogenesis IMP
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 biological_processGO:0072659 protein localization to plasma membrane ISS
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment ISS
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030137 COPI-coated vesicle ISS
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0030663 COPI-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA
 cellular_componentGO:0042589 zymogen granule membrane ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
COPII-mediated vesicle transport
Cargo concentration in the ER
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000269 abnormal looping morphogenesis "atypical bending of the primitive heart tube during early development" [J:27443]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Tmed299J/Tmed2Gt(PST809)Mfgc
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6J

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002861 abnormal tail bud morphology "anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Tmed299J/Tmed2Gt(PST809)Mfgc
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6J

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
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Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003794 delayed somite formation "late onset of the induction and/or differentiation of the somites" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:99723]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004086 absent heartbeat "lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)" [J:69362, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004251 failure of looping morphogenesis "failure of the primitive heart tube to initiate or complete looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009656 delayed chorioallantoic fusion "late onset of the initiation and/or completion of the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0012062 small tail bud "decreased size or area of the primordial region of the embryo that arises to form the tail of the adult" [MGI:anna]
Show

Allelic Composition: Apctm1Rsmi/Apc+,Tg(Fabp1-cre)1Jig/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Tmed299J/Tmed2Gt(PST809)Mfgc
Genetic Background: involves: 129S2/SvPas * C3HeB/FeJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014867 Surf4 / Q64310 / Surfeit locus protein 4 / O15260* / surfeit 4*  / complex
 ENSMUSG00000032679 Cd59a / O55186 / CD59A glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / reaction / complex
 ENSMUSG00000021248 Q9D1D4 / Tmed10 / Transmembrane emp24 domain-containing protein 10 / P49755* / transmembrane p24 trafficking protein 10*  / complex
 ENSMUSG00000029390 Tmed2 / Q9R0Q3 / transmembrane p24 trafficking protein 2 / Q15363*  / complex
 ENSMUSG00000001827 Folr1 / P35846 / Folate receptor alpha / P15328* / folate receptor 1*  / complex / reaction
 ENSMUSG00000058569 Tmed9 / Q99KF1 / transmembrane p24 trafficking protein 9 / Q9BVK6*  / complex
 ENSMUSG00000068686 Cd59b / P58019 / CD59B glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / complex / reaction






 

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