ENSG00000086598


Homo sapiens

Features
Gene ID: ENSG00000086598
  
Biological name :TMED2
  
Synonyms : Q15363 / TMED2 / transmembrane p24 trafficking protein 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: q24.31
Gene start: 123584531
Gene end: 123598577
  
Corresponding Affymetrix probe sets: 200087_s_at (Human Genome U133 Plus 2.0 Array)   204426_at (Human Genome U133 Plus 2.0 Array)   204427_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000441161
Ensembl peptide - ENSP00000262225
Ensembl peptide - ENSP00000405845
NCBI entrez gene - 10959     See in Manteia.
RefSeq - NM_001321445
RefSeq - NM_006815
RefSeq Peptide - NP_001308374
RefSeq Peptide - NP_006806
swissprot - E7EQ72
swissprot - Q6FHT8
swissprot - Q15363
swissprot - F5GX39
Ensembl - ENSG00000086598
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmed2ENSDARG00000026908Danio rerio
 TMED2ENSGALG00000003307Gallus gallus
 Tmed2ENSMUSG00000029390Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TMED7 / Q9Y3B3 / transmembrane p24 trafficking protein 7ENSG0000013497034
TMED3 / Q9Y3Q3 / transmembrane p24 trafficking protein 3ENSG0000016655730
TMED7-TICAM2 / TMED7-TICAM2 readthroughENSG0000025120129
TMED5 / Q9Y3A6 / transmembrane p24 trafficking protein 5ENSG0000011750027
TMED1 / Q13445 / transmembrane p24 trafficking protein 1ENSG0000009920322


Protein motifs (from Interpro)
Interpro ID Name
 IPR009038  GOLD domain
 IPR015720  TMP21-related
 IPR036598  GOLD domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0001843 neural tube closure IEA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0001893 maternal placenta development IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0006886 intracellular protein transport IDA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0032525 somite rostral/caudal axis specification IEA
 biological_processGO:0034260 negative regulation of GTPase activity IDA
 biological_processGO:0035264 multicellular organism growth IEA
 biological_processGO:0035459 cargo loading into vesicle TAS
 biological_processGO:0036342 post-anal tail morphogenesis IEA
 biological_processGO:0048205 COPI coating of Golgi vesicle TAS
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0048598 embryonic morphogenesis IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0072659 protein localization to plasma membrane IDA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle TAS
 cellular_componentGO:0030137 COPI-coated vesicle IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0030663 COPI-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032580 Golgi cisterna membrane IEA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA
 cellular_componentGO:0042589 zymogen granule membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Pre-NOTCH Processing in Golgi
COPII-mediated vesicle transport
Cargo concentration in the ER
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000086598 TMED2 / Q15363 / transmembrane p24 trafficking protein 2  / complex
 ENSG00000085063 CD59 / P13987 / CD59 molecule (CD59 blood group)  / complex / reaction
 ENSG00000148248 SURF4 / O15260 / surfeit 4  / complex
 ENSG00000110195 FOLR1 / P15328 / folate receptor 1  / reaction / complex
 ENSG00000170348 P49755 / TMED10 / transmembrane p24 trafficking protein 10  / complex
 ENSG00000184840 TMED9 / Q9BVK6 / transmembrane p24 trafficking protein 9  / complex






 

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