ENSG00000170348


Homo sapiens

Features
Gene ID: ENSG00000170348
  
Biological name :TMED10
  
Synonyms : P49755 / TMED10 / transmembrane p24 trafficking protein 10
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q24.3
Gene start: 75131470
Gene end: 75176631
  
Corresponding Affymetrix probe sets: 200929_at (Human Genome U133 Plus 2.0 Array)   212352_s_at (Human Genome U133 Plus 2.0 Array)   238886_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000303145
Ensembl peptide - ENSP00000450726
NCBI entrez gene - 10972     See in Manteia.
OMIM - 605406
RefSeq - NM_006827
RefSeq Peptide - NP_006818
swissprot - A0A024R6I3
swissprot - G3V2K7
swissprot - P49755
Ensembl - ENSG00000170348
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmed10ENSDARG00000041391Danio rerio
 TMED10ENSGALG00000010318Gallus gallus
 Q9D1D4ENSMUSG00000021248Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009038  GOLD domain
 IPR015720  TMP21-related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006886 intracellular protein transport IDA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0035459 cargo loading into vesicle TAS
 biological_processGO:0035964 COPI-coated vesicle budding IDA
 biological_processGO:0043279 response to alkaloid IEA
 biological_processGO:0045055 regulated exocytosis ISS
 biological_processGO:0048199 vesicle targeting, to, from or within Golgi ISS
 biological_processGO:0048205 COPI coating of Golgi vesicle TAS
 biological_processGO:0048208 COPII vesicle coating TAS
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:1902003 regulation of amyloid-beta formation IMP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005801 cis-Golgi network ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0012507 ER to Golgi transport vesicle membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030133 transport vesicle TAS
 cellular_componentGO:0030137 COPI-coated vesicle ISS
 cellular_componentGO:0030140 trans-Golgi network transport vesicle ISS
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0030667 secretory granule membrane ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042589 zymogen granule membrane ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0070765 gamma-secretase complex IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019905 syntaxin binding IPI


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Cargo concentration in the ER
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000086598 TMED2 / Q15363 / transmembrane p24 trafficking protein 2  / complex
 ENSG00000110195 FOLR1 / P15328 / folate receptor 1  / complex / reaction
 ENSG00000184840 TMED9 / Q9BVK6 / transmembrane p24 trafficking protein 9  / complex
 ENSG00000085063 CD59 / P13987 / CD59 molecule (CD59 blood group)  / reaction / complex
 ENSG00000148248 SURF4 / O15260 / surfeit 4  / complex
 ENSG00000170348 P49755 / TMED10 / transmembrane p24 trafficking protein 10  / complex






 

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