ENSMUSG00000021248


Mus musculus

Features
Gene ID: ENSMUSG00000021248
  
Biological name :Tmed10
  
Synonyms : Q9D1D4 / Tmed10 / Transmembrane emp24 domain-containing protein 10
  
Possible biological names infered from orthology : P49755 / transmembrane p24 trafficking protein 10
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: D2
Gene start: 85340614
Gene end: 85374847
  
Corresponding Affymetrix probe sets: 10401661 (MoGene1.0st)   10408684 (MoGene1.0st)   1424707_at (Mouse Genome 430 2.0 Array)   1424708_at (Mouse Genome 430 2.0 Array)   1439444_x_at (Mouse Genome 430 2.0 Array)   1439462_x_at (Mouse Genome 430 2.0 Array)   1454688_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152811
Ensembl peptide - ENSMUSP00000037583
NCBI entrez gene - 68581     See in Manteia.
MGI - MGI:1915831
RefSeq - NM_026775
RefSeq Peptide - NP_081051
swissprot - A0A1Y7VM54
swissprot - Q9D1D4
Ensembl - ENSMUSG00000021248
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmed10ENSDARG00000041391Danio rerio
 TMED10ENSGALG00000010318Gallus gallus
 P49755ENSG00000170348Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009038  GOLD domain
 IPR015720  TMP21-related


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0006886 intracellular protein transport TAS
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER ISS
 biological_processGO:0007030 Golgi organization IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0035964 COPI-coated vesicle budding IEA
 biological_processGO:0043279 response to alkaloid IEA
 biological_processGO:0045055 regulated exocytosis IEP
 biological_processGO:0048199 vesicle targeting, to, from or within Golgi IEP
 biological_processGO:0051259 protein complex oligomerization IEA
 biological_processGO:1902003 regulation of amyloid-beta formation IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005801 cis-Golgi network ISS
 cellular_componentGO:0005886 plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030137 COPI-coated vesicle IEA
 cellular_componentGO:0030140 trans-Golgi network transport vesicle ISS
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0030667 secretory granule membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0042589 zymogen granule membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0070765 gamma-secretase complex IEA
 molecular_functionGO:0019905 syntaxin binding IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Cargo concentration in the ER
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Thbs1tm1.1(KOMP)Vlcg/Thbs1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Thbs1tm1.1(KOMP)Vlcg/Ucd

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Thbs1tm1.1(KOMP)Vlcg/Thbs1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Thbs1tm1.1(KOMP)Vlcg/Ucd

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Dlk1tm1Hsul/Dlk1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Tcf7l2tm1a(EUCOMM)Wtsi/Tcf7l2+
Genetic Background: C57BL/6N-Tcf7l2tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000014867 Surf4 / Q64310 / Surfeit locus protein 4 / O15260* / surfeit 4*  / complex
 ENSMUSG00000032679 Cd59a / O55186 / CD59A glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / reaction / complex
 ENSMUSG00000029390 Tmed2 / Q9R0Q3 / transmembrane p24 trafficking protein 2 / Q15363*  / complex
 ENSMUSG00000068686 Cd59b / P58019 / CD59B glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / complex / reaction
 ENSMUSG00000021248 Q9D1D4 / Tmed10 / Transmembrane emp24 domain-containing protein 10 / P49755* / transmembrane p24 trafficking protein 10*  / complex
 ENSMUSG00000001827 Folr1 / P35846 / Folate receptor alpha / P15328* / folate receptor 1*  / complex / reaction
 ENSMUSG00000058569 Tmed9 / Q99KF1 / transmembrane p24 trafficking protein 9 / Q9BVK6*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr