ENSMUSG00000001827


Mus musculus

Features
Gene ID: ENSMUSG00000001827
  
Biological name :Folr1
  
Synonyms : Folate receptor alpha / Folr1 / P35846
  
Possible biological names infered from orthology : folate receptor 1 / P15328
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: E2
Gene start: 101858331
Gene end: 101870788
  
Corresponding Affymetrix probe sets: 10566034 (MoGene1.0st)   1450995_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114919
Ensembl peptide - ENSMUSP00000121947
Ensembl peptide - ENSMUSP00000121374
Ensembl peptide - ENSMUSP00000118547
Ensembl peptide - ENSMUSP00000117175
Ensembl peptide - ENSMUSP00000116068
Ensembl peptide - ENSMUSP00000115360
Ensembl peptide - ENSMUSP00000115077
Ensembl peptide - ENSMUSP00000102594
Ensembl peptide - ENSMUSP00000102595
Ensembl peptide - ENSMUSP00000102596
Ensembl peptide - ENSMUSP00000102598
Ensembl peptide - ENSMUSP00000102599
Ensembl peptide - ENSMUSP00000114167
Ensembl peptide - ENSMUSP00000114633
NCBI entrez gene - 14275     See in Manteia.
MGI - MGI:95568
RefSeq - XM_006507363
RefSeq - XM_006507361
RefSeq - XM_006507360
RefSeq - XM_006507367
RefSeq - XM_006507366
RefSeq - XM_006507365
RefSeq - NM_001252552
RefSeq - NM_001252553
RefSeq - NM_001252554
RefSeq - NM_008034
RefSeq - XM_006507370
RefSeq - XM_006507369
RefSeq - XM_006507368
RefSeq - XM_006507364
RefSeq Peptide - NP_001239483
RefSeq Peptide - NP_001239481
RefSeq Peptide - NP_001239482
RefSeq Peptide - NP_032060
swissprot - Q9R223
swissprot - P35846
swissprot - E9Q543
swissprot - A0A0R4J1Q2
swissprot - D3Z711
swissprot - E9PXB5
swissprot - E9PXL5
swissprot - E9PYD9
swissprot - E9Q3D3
Ensembl - ENSMUSG00000001827
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 IZUMO1RENSDARG00000102442Danio rerio
 FOLR1ENSGALG00000017343Gallus gallus
 FOLR1ENSG00000110195Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Folr2 / Q05685 / Folate receptor beta / P14207*ENSMUSG0000003272567
Q9EQF4 / Izumo1r / IZUMO1 receptor, JUNO / A6ND01*ENSMUSG0000003193344


Protein motifs (from Interpro)
Interpro ID Name
 IPR004269  Folate receptor
 IPR018143  Folate receptor-like
 IPR032935  Folate receptor alpha


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003147 neural crest cell migration involved in heart formation IMP
 biological_processGO:0003253 cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
 biological_processGO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane TAS
 biological_processGO:0015884 folic acid transport IEA
 biological_processGO:0017015 regulation of transforming growth factor beta receptor signaling pathway IMP
 biological_processGO:0031103 axon regeneration IMP
 biological_processGO:0046655 folic acid metabolic process IMP
 biological_processGO:0048678 response to axon injury IMP
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IMP
 biological_processGO:0061626 pharyngeal arch artery morphogenesis IMP
 biological_processGO:0061713 anterior neural tube closure IMP
 biological_processGO:0071231 cellular response to folic acid ISO
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0030136 clathrin-coated vesicle IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0031362 anchored component of external side of plasma membrane ISS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0031526 brush border membrane IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IEA
 molecular_functionGO:0005542 folic acid binding IEA
 molecular_functionGO:0008144 drug binding ISO
 molecular_functionGO:0008517 folic acid transmembrane transporter activity IEA
 molecular_functionGO:0051870 methotrexate binding ISO
 molecular_functionGO:0061714 folic acid receptor activity ISO


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Cargo concentration in the ER
COPI-mediated anterograde transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0000490 abnormal crypts of Lieberkuhn morphology "malformation or defects in the tubular intestinal glands found in the mucosal membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0000786 abnormal neuroepithelial layer differentiation "malformation or arrest of differentiation or patterning of the epithelial layer of the brain" [J:45302]
Show

Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0002950 abnormal neural crest cell migration "defect in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0006076 abnormal circulating homocysteine level "aberrant concentration in the blood of this amino acid" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0006294 absent optic vesicle "absence of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop" [J:94391, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0006342 absent first branchial arch "missing the first branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0011172 abnormal otic pit morphology "any structural anomaly of the pair of depressions of thickened otic placode epithelium, that further develops into the otic vesicles" [ISBN:0-683-40008-8]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0011230 abnormal folic acid level "any anomaly in the concentration of the vitamin B family member that stimulates the hematopoietic system, is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses, and is used in the treatment and prevention of folate deficiencies and megaloblastic anemia" [MESH:D03.438.733.631.400]
Show

Allelic Composition: Spink5tm1Hov/Spink5tm1Hov
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Folr1tm1Fnn/Folr1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0012136 absent forebrain "absence of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]
Show

Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
Show

Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0012708 delayed rostral neuropore closure "a delay in the fusion of the cephalic neural folds" [MGI:anna]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0013183 absent trigeminal ganglion "absence of the group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [MGI:anna]
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Allelic Composition: Ptprcloc/Ptprcloc
Genetic Background: C57BL/6JSfdAnu-Ptprcloc/AnuApb

 MP:0013278 decreased fasted circulating glucose level "reduction in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza]
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Allelic Composition: Folh1tm1b(KOMP)Wtsi/Folh1tm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Folh1tm1b(KOMP)Wtsi/J

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
Show

Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021248 Q9D1D4 / Tmed10 / Transmembrane emp24 domain-containing protein 10 / P49755* / transmembrane p24 trafficking protein 10*  / complex / reaction
 ENSMUSG00000029390 Tmed2 / Q9R0Q3 / transmembrane p24 trafficking protein 2 / Q15363*  / complex / reaction






 

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