ENSMUSG00000032679


Mus musculus

Features
Gene ID: ENSMUSG00000032679
  
Biological name :Cd59a
  
Synonyms : Cd59a / CD59A glycoprotein / O55186
  
Possible biological names infered from orthology : AL049629.2 / CD59 / CD59 glycoprotein / CD59 molecule (CD59 blood group) / P13987
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E2
Gene start: 104095801
Gene end: 104115354
  
Corresponding Affymetrix probe sets: 10474229 (MoGene1.0st)   1418710_at (Mouse Genome 430 2.0 Array)   1429830_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048041
Ensembl peptide - ENSMUSP00000132774
NCBI entrez gene - 12509     See in Manteia.
MGI - MGI:109177
RefSeq - XM_006498651
RefSeq - NM_001111060
RefSeq - NM_007652
RefSeq - XM_006498650
RefSeq Peptide - NP_031678
RefSeq Peptide - NP_001104530
swissprot - O55186
swissprot - A2BI31
Ensembl - ENSMUSG00000032679
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040371Gallus gallus
 CD59ENSG00000085063Homo sapiens
 P13987ENSG00000284969Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cd59b / P58019 / CD59B glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*ENSMUSG0000006868667


Protein motifs (from Interpro)
Interpro ID Name
 IPR016054  Ly-6 antigen/uPA receptor-like
 IPR027101  CD59 glycoprotein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001775 cell activation IBA
 biological_processGO:0001971 negative regulation of activation of membrane attack complex IMP
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway IMP
 biological_processGO:0045916 negative regulation of complement activation IDA
 biological_processGO:0090272 negative regulation of fibroblast growth factor production IDA
 cellular_componentGO:0005576 extracellular region IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 molecular_functionGO:0001848 complement binding IBA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
Cargo concentration in the ER
Neutrophil degranulation
COPI-mediated anterograde transport
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

 MP:0000315 hemoglobinuria "the presence of hemoglobin in the urine, including certain closely related pigments that are formed from slight alteration of the hemoglobin molecule" [J:82330, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0000332 hemoglobinemia "the presence of free hemoglobin in the blood plasma, an indication of significant intravascular hemolysis" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:82330]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(YAC46)668Hay/0
Genetic Background: involves: FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Cd55tm1Song/Cd55tm1Song
Genetic Background: B6.129S6-Cd55tm1Song

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cd55tm1Song/Cd55tm1Song
Genetic Background: B6.129S6-Cd55tm1Song

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129 * BALB/c

 MP:0002471 abnormal complement cascade "impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Col1a1tm1Jae/Col1a1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

Allelic Composition: Cd59atm1Song/Cd59atm1Song,Cd55tm1Song/Cd55tm1Song
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129

Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

Allelic Composition: Cd55tm1Song/Cd55tm1Song,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd55tm1Song Cd59atm1Bpm

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0003657 abnormal erythrocyte lysis "increase or decrease in the ability of RBCs to withstand changes in osmolarity" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: ArTfm/Y,Insl3tm1Imad/Insl3tm1Imad
Genetic Background: involves: 129/Sv * CD-1 * STOCK EdaTa

 MP:0003724 susceptibility to induced arthritis "more likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129

 MP:0003814 vascular smooth muscle cell hypoplasia "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0004041 increased susceptibility to kidney reperfusion injury "an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia " [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

 MP:0004153 increased renal tubule apoptosis "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

Allelic Composition: Cd55tm1Song/Cd55tm1Song,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd55tm1Song Cd59atm1Bpm

 MP:0004799 increased susceptibility to experimental autoimmune encephalomyelitis "greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Htttm1Hay/Htttm1Hay,Tg(YAC46)668Hay/0
Genetic Background: involves: FVB/N

 MP:0004823 increased susceptibility to experimental autoimmune myasthenia gravis "greater likelihood that an organism will develop disease symptoms similar to human myasthenia gravis upon induction with antigens to acetylcholine receptor subunits" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

Allelic Composition: Cd55tm1Song/Cd55tm1Song,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd55tm1Song Cd59atm1Bpm

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129

 MP:0005339 increased susceptibility to atherosclerosis "more likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129 * BALB/c

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

Allelic Composition: C3tm1Crr/C3tm1Crr,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm C3tm1Crr

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

 MP:0005489 vascular smooth muscle cell hyperplasia "increased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:48446]
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Allelic Composition: Apoetm1Bres/Apoetm1Bres,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129 * 129P2/OlaHsd

 MP:0005546 choroidal neovascularization "new, abnormal, vessel development of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

 MP:0008098 decreased plasma cell number "reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd55tm1Song/Cd55tm1Song,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd55tm1Song Cd59atm1Bpm

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd59atm1Bpm

Allelic Composition: Cd55tm1Song/Cd55tm1Song,Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: B6.129-Cd55tm1Song Cd59atm1Bpm

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129 * BALB/c

 MP:0010653 abnormal Wallerian degeneration "any anomaly in the process of progressive degeneration of axons distal to an injury" [PMID:20345246]
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Allelic Composition: Cd59atm1Bpm/Cd59atm1Bpm
Genetic Background: involves: 129

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015083 C8g / Q8VCG4 / Complement component C8 gamma chain / P07360* / complement C8 gamma chain*  / complex / reaction
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / reaction / complex
 ENSMUSG00000022149 C9 / complement C9 / P02748*  / reaction / complex
 ENSMUSG00000022181 C6 / complement component 6 / P13671* / complement C6*  / complex / reaction
 ENSMUSG00000029656 C8b / Q8BH35 / Complement component C8 beta chain / P07358* / complement C8 beta chain*  / reaction / complex
 ENSMUSG00000029390 Tmed2 / Q9R0Q3 / transmembrane p24 trafficking protein 2 / Q15363*  / reaction / complex
 ENSMUSG00000021248 Q9D1D4 / Tmed10 / Transmembrane emp24 domain-containing protein 10 / P49755* / transmembrane p24 trafficking protein 10*  / complex / reaction
 ENSMUSG00000035031 C8a / Q8K182 / Complement component C8 alpha chain / P07357* / complement C8 alpha chain*  / complex / reaction
 ENSMUSG00000079105 C7 / complement component 7 / P10643* / complement C7*  / reaction / complex






 

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