ENSMUSG00000035031


Mus musculus

Features
Gene ID: ENSMUSG00000035031
  
Biological name :C8a
  
Synonyms : C8a / Complement component C8 alpha chain / Q8K182
  
Possible biological names infered from orthology : complement C8 alpha chain / P07357
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C6
Gene start: 104815679
Gene end: 104876398
  
Corresponding Affymetrix probe sets: 10514763 (MoGene1.0st)   1428012_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102420
Ensembl peptide - ENSMUSP00000047606
Ensembl peptide - ENSMUSP00000067541
NCBI entrez gene - 230558     See in Manteia.
MGI - MGI:2668347
RefSeq - XM_006502943
RefSeq - NM_001290645
RefSeq - NM_001316667
RefSeq - NM_146148
RefSeq - XM_006502941
RefSeq Peptide - NP_001277574
RefSeq Peptide - NP_001303596
RefSeq Peptide - NP_666260
swissprot - A2A998
swissprot - Q8K182
swissprot - A2A997
Ensembl - ENSMUSG00000035031
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 c8aENSDARG00000039516Danio rerio
 C8AENSGALG00000010850Gallus gallus
 C8AENSG00000157131Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
C8b / Q8BH35 / Complement component C8 beta chain / P07358* / complement C8 beta chain*ENSMUSG0000002965632
C6 / complement component 6 / P13671* / complement C6*ENSMUSG0000002218130
C9 / complement C9 / P02748*ENSMUSG0000002214927
C7 / complement component 7 / P10643* / complement C7*ENSMUSG0000007910527


Protein motifs (from Interpro)
Interpro ID Name
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001862  Membrane attack complex component/perforin/complement C9
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR016186  C-type lectin-like/link domain superfamily
 IPR020863  Membrane attack complex component/perforin domain, conserved site
 IPR020864  Membrane attack complex component/perforin (MACPF) domain
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR036055  LDL receptor-like superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily
 IPR037565  Complement component C8 alpha chain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006956 complement activation ISO
 biological_processGO:0006957 complement activation, alternative pathway IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0019835 cytolysis IEA
 biological_processGO:0045087 innate immune response IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005579 membrane attack complex ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001848 complement binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Terminal pathway of complement
Regulation of Complement cascade


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000015083 C8g / Q8VCG4 / Complement component C8 gamma chain / P07360* / complement C8 gamma chain*  / complex
 ENSMUSG00000022037 Clu / Q06890 / Clusterin Clusterin beta chain Clusterin alpha chain / P10909* / clusterin*  / complex / reaction
 ENSMUSG00000029656 C8b / Q8BH35 / Complement component C8 beta chain / P07358* / complement C8 beta chain*  / complex
 ENSMUSG00000068686 Cd59b / P58019 / CD59B glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / reaction / complex
 ENSMUSG00000032679 Cd59a / O55186 / CD59A glycoprotein / CD59* / P13987* / AL049629.2* / CD59 glycoprotein * / CD59 molecule (CD59 blood group)*  / complex / reaction
 ENSMUSG00000017344 Vtn / P29788 / vitronectin / P04004*  / reaction / complex
 ENSMUSG00000022149 C9 / complement C9 / P02748*  / complex / reaction
 ENSMUSG00000079105 C7 / complement component 7 / P10643* / complement C7*  / complex / reaction
 ENSMUSG00000022181 C6 / complement component 6 / P13671* / complement C6*  / reaction / complex
 ENSMUSG00000026874 Hc / P06684 / hemolytic complement / C5* / P01031* / complement C5*  / complex / reaction






 

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